Follicular Development in the Infant Human Ovary

Lintern‐Moore, Sue; Peters, Hannah; Moore, G. P. M.; Faber, Mogens

doi:10.1530/jrf.0.0390053

Cited by 139 publications

(71 citation statements)

References 28 publications

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“…primordial, primary and secondary), was smaller than those observed in ewes (Lundy et al, 1999) and cows (Van Wezel and Rodgers, 1996, Braw-Tal and Yossefi, 1997, but was similar to those observed in humans (Lintern-Moore et al, 1974). However, the mean and range in the number of granulosa cells at the equatorial section were compatible to those described for ewes (Lundy et al, 1999), cows (Braw-Tal and Yossefi, 1997) and humans (Lintern-Moore et al, 1974), even when the diameter of oocytes and follicles was smaller. These differences may be species-specific or due to differences in measurement techniques.…”

Section: Discussionsupporting

confidence: 79%

Light microscopical and ultrastructural characterization of goat preantral follicles

Lucci

Silva

Carvalho

et al. 2001

Small Ruminant Research

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Light microscopical and ultrastructural characterization of goat preantral follicles AbstractGoat ovarian preantral follicles were morphologically and ultrastructurally described in this work. Primordial follicles are oocytes surrounded by one layer of squamous or squamouscuboidal granulosa cells; primary follicles have a single layer of cuboidal granulosa cells, and secondary follicles are oocytes surrounded by two or more layers of cuboidal granulosa cells. At all developmental stages a thick layer of glycoproteins, the basement membrane, surrounded the preantral follicles. The quiescent oocyte is spherical or oval and it has a large eccentrically located nucleus with a conspicuous nucleolus. The organelles were uniformly distributed in the cytoplasm. A large number of vesicles were spread throughout the cytoplasm in all the oocytes. The cytoplasm of oocytes also contains numerous rounded mitochondria besides the usual organelles. As the follicle develops, the mitochondria become elongated. The communication between the oocyte and the granulosa cells is apparently mediated through endocytosis as indicated by the abundant coated pits and vesicles noted in the cortical cytoplasm of the oocyte. The oocyte plasma membrane presented projections that penetrated between adjacent granulosa cells and a few short microvilli lying parallel to the oocyte surface. In secondary follicles, patches of zona pellucida material were observed. Overall, the results indicate that the morphological and ultrastructural organization of caprine preantral follicles resembles that of other mammals. However, some particularities were observed, and that may indicate species specific differences.

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Section: Discussionsupporting

confidence: 79%

Light microscopical and ultrastructural characterization of goat preantral follicles

Lucci

Silva

Carvalho

et al. 2001

Small Ruminant Research

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“…The results showed that the mean diameter of zebu oocytes and follicles and the mean number of granulosa cells at the equatorial section were similar to those observed for European cattle (Van Wezel and Rodgers, 1996, Braw-Tal and Yossefi, 1997and Hyttel et al, 1997 in all three developmental stages evaluated (i.e., primordial, primary and small secondary follicles). Also, our results were similar to those described for humans (Lintern-Moore et al, 1974), but different from those described for ewes (Lundy et al, 1999) and goats (Lucci et al, 2001). …”

Section: Discussionsupporting

confidence: 68%

Morphometric and ultrastructural characterization of Bos indicus preantral follicles

Kacinskis¹,

Lucci²,

Luque³

et al. 2005

Animal Reproduction Science

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Morphometric and ultrastructural characterization of Bos indicus preantral folliclesMirella Ávila Kacinskis Carolina Madeira Lucci Maria Carolina Aquino Luque Sônia Nair Báo AbstractThe aim of the present study was to characterize the ultrastructure of zebu cow preantral follicles (PAFs). Ovarian cortex samples were processed for light and transmission electron microscopy. Primordial follicles consisted of an oocyte surrounded by one layer of flattened or flattened-cuboidal granulosa cells. The oocyte contained a large and usually eccentric nucleus. Most organelles were located at the perinuclear ooplasm. Round shaped mitochondria, which contained electron-dense granules, smooth and rough endoplasma reticulum and a Golgi apparatus were also observed. Vesicles and coated pits were often observed in the cortical ooplasm. In primary follicles, the oocyte was surrounded by one layer of cuboidal granulosa cells. Short microvilli were observed on the oolema. Secondary follicles consisted of an oocyte surrounded by a variable number of layers of cuboidal granulosa cells. Small secondary follicles had an ultrastructure very similar to that observed in primary follicles. At this follicular stage, the zona pellucida was beginning to form around the oocyte. In large secondary follicles, the zona pellucida was totally developed around the oocyte. Several granulosa cell projections could be detected that were encroaching into the zona pellucida and protruding towards the oocyte, where gap junctions were observed between oocyte and granulosa cell membranes. Organelles within the oocyte were located at the periphery of the ooplasm, and clusters of cortical granules were observed. Round mitochondria were abundant in all developmental stages. In conclusion, this study described the ultrastructure of zebu cow PAFs, and some unique characteristics could be observed as compared with what has been reported for follicles of Bos taurus cattle.

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“…primordial, primary and secondary). Also, our results were similar to those described for humans [39], but different from those described for ewes [40] and goats [41]. In addition, some polyovular follicles could be observed in Zebu cow ovaries.…”

Section: Discussionsupporting

confidence: 67%

Zebu (Bos indicus) ovarian preantral follicles: morphological characterization and development of an efficient isolation method

et al. 2002

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Zebu (Bos indicus) ovarian preantral follicles: morphological characterization and development of an efficient isolation methodCarolina Madeira Lucci Rodolfo Rumpf José Ricardo Figueiredo Sonia Nair Béo AbstractPreantral follicles are a major source of oocytes, and their utilization as an important tool to store large number of female gametes for future use in reproductive programs has been investigated. The increasing importance of studies in this subject, together with the important role of Zebu cattle in the economy of tropical and subtropical countries as well as their well-known differences from European cattle, led to this research. The present study aims to determine the best size interval for sectioning ovarian tissue to isolate preantral follicles from Zebu cows using a tissue chopper and to evaluate the follicular quality after isolation. Furthermore, it aims to provide information about the Zebu cow preantral follicle population and use this data (as a control) to evaluate the effectiveness of the tested isolation method. Testing eight different tissue sectioning size intervals, it was possible to conclude that the 125-pm-section interval is shown to be better than the intervals of 25, 50, 175 and 200 pm to isolate preantral follicles from Zebu cow ovaries. The 125-pm interval allowed the recovery of 26,050±1611 (meaniS.E.M.) preantral follicles per one-half ovary, while the number of preantral follicles in situ estimated by evaluation of histological sections was 35,28812342 per one-half ovary. Thus, the mean (iS.E.M.) recovery rate (=[number of preantral follicles isolated/number of preantral follicles in situ in the same ovary] x 100) was 74.3±4.3%. The morphometrical analysis showed that Bos indicus preantral follicles are similar to B. taurus preantral follicles based on previous reports. In conclusion, this study showed that a simple, mechanical method can be used effectively to isolate a large number of intact preantral follicles from Zebu cow ovaries, with a high recovery rate.

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Follicular Development in the Infant Human Ovary

Cited by 139 publications

References 28 publications

Light microscopical and ultrastructural characterization of goat preantral follicles

Light microscopical and ultrastructural characterization of goat preantral follicles

Morphometric and ultrastructural characterization of Bos indicus preantral follicles

Zebu (Bos indicus) ovarian preantral follicles: morphological characterization and development of an efficient isolation method

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