Follicular fluid concentrations of vascular endothelial growth factor, inhibin A and inhibin B in IVF cycles: are they markers for ovarian response and pregnancy outcome?

Öçal, Pelin; Aydın, Seval; Çepni, İsmail; Idil, Sevda; İdil, Mehmet; Uzun, Hafize; Benian, Ali

doi:10.1016/j.ejogrb.2004.01.034

Cited by 60 publications

(51 citation statements)

References 25 publications

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“…Inhibins act as a local regulator of cell growth, maturation, and steroidogenesis in the human ovary. Similarly, follicular fluid levels of inhibins A and B have been reported to be correlated with the outcome of IVF (27).…”

mentioning

confidence: 95%

“…Follicular levels of EGF have been reported to be inversely correlated with IVF outcome (14), whereas IGF-I concentration has been found to correlate with IVF outcome (24,25). Follicular levels of inhibins A and B were found to reflect ovarian function in terms of oocyte number and quality (26,27). Inhibins act as a local regulator of cell growth, maturation, and steroidogenesis in the human ovary.…”

mentioning

confidence: 95%

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Comparison of preovulatory follicular concentrations of epidermal growth factor, insulin-like growth factor-I, and inhibins A and B in women undergoing assisted conception treatment with gonadotropin-releasing hormone (GnRH) agonists and GnRH antagonists

Uluğ

Turan

Tosun

et al. 2007

Fertility and Sterility

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confidence: 95%

mentioning

confidence: 95%

Comparison of preovulatory follicular concentrations of epidermal growth factor, insulin-like growth factor-I, and inhibins A and B in women undergoing assisted conception treatment with gonadotropin-releasing hormone (GnRH) agonists and GnRH antagonists

Uluğ

Turan

Tosun

et al. 2007

Fertility and Sterility

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“…Many tests have been suggested to predict the probability of pregnancy in IVF cycles, such as FSH [1] and estradiol [2] on the third day of the cycle, FSH levels after treatment with clomiphene [3], levels of inhibin A and inhibin B [4], number of ovarian antral follicles [5,6], antimullerian hormone [7] and the influence of women age [8]. These tests have been described to have an acceptable predictive power for IVF outcome, but reports with conflicting results have been described [9,10]. The majority of these tests were conducted in an isolated manner and prior to ovarian stimulation.…”

Section: Introductionmentioning

confidence: 99%

Prediction of pregnancy in IVF cycles on the fourth day of ovarian stimulation

Carrera-Rotllan

Estrada-Garcı́a

Sarquella-Ventura

2007

J Assist Reprod Genet

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Purpose Prediction of IVF outcome on the first days of ovarian stimulation has focused clinical research for many years. The aim of this work is to predict the probability of pregnancy on the fourth day of ovarian stimulation for IVF cycle, using parameters usually determined in this stageestradiol, antral follicle count-together with parameters determined previously: FSH on the third day of cycle and women age. Materials and methods One hundred and ten patients with primary infertility due to a tubal factor were recruited to participate in a prospective study. FSH was determined on the third day of spontaneous cycle. Antral follicles and estradiol were measured on the fourth day of ovarian stimulation. After oocyte pick-up, quality and quantity of oocytes and embryos and pregnancy rates were assessed. Results In stepwise multiple logistic regression the variables with better predictiveness over pregnancy are: antral follicles count, estradiol and woman age. The logistic regression analyses demonstrate that the capacity of the model that uses these variables to predict pregnancy is 75%, with a positive predictive value of 69% and a negative predictive value of 80%. Conclusions On the fourth day of ovarian stimulation of IVF cycles, the variables with highest predictiveness are: antral follicle count, estradiol and women age. When these variables are included in a model of prediction, the capacity to predict pregnancy is 75%.

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“…On the day of hCG trigger (d-hCG), due to increased number of follicles, high estradiol levels lead to low endometrial receptivity and thus decreased pregnancy rates in IVF cycles [12,13]. Different cutoffs of serum estradiol levels have been observed on day 4-6 and on the day of hCG trigger during the stimulation cycle by some researchers [14].…”

Section: Introductionmentioning

confidence: 99%

“…Previous reports suggest the role of various parameters like levels of hormones [follicular stimulating hormone (FSH), estradiol, inhibin A, and inhibin B], number of ovarian antral follicles, anti-mullerian hormone, and the influence of woman's age in predicting successful pregnancy in IVF cycles [3,4,[5][6][7][8][9][10]. However, no consensus exists till date [11,12].…”

Section: Introductionmentioning

confidence: 99%

Estradiol Level on Day 2 and Day of Trigger: A Potential Predictor of the IVF-ET Success

Prasad

Kumar

Singhal

et al. 2014

J Obstet Gynecol India

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Objective To evaluate role of serum estradiol levels in predicting likelihood of pregnancy in women undergoing GnRH-a protocol in IVF-ET cycles. Design A 3-year retrospective analysis of estradiol levels on down-regulated day 2, day 6, and day of hCG trigger and subsequent clinical pregnancy rates. Setting A university hospital tertiary referral centre. Population or Sample Women undergoing IVF treatment. Methods Hormonal assessment on the down-regulated day 2, day 6, and day of hCG trigger. Main Outcome Measure(s) Comparison of hormonal profile, antral follicular count on day 2, endometrial thickness on day of trigger, and number of oocytes retrieved between pregnant and the non-pregnant group. The prediction of IVF success was based on the quantitative levels of estradiol on a specific day in down-regulated cycle. Result(s) The overall pregnancy rate was 32.25 % (50/ 160). Estradiol level on down-regulated day 2 was 31.9 ± 12.6 and on the day of trigger was 1,996.46 ± 1,252.36 in pregnant women, which was significantly higher as compared to estradiol levels in nonpregnant women (27.6 ± 12.3 and 1,525

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Follicular fluid concentrations of vascular endothelial growth factor, inhibin A and inhibin B in IVF cycles: are they markers for ovarian response and pregnancy outcome?

Cited by 60 publications

References 25 publications

Comparison of preovulatory follicular concentrations of epidermal growth factor, insulin-like growth factor-I, and inhibins A and B in women undergoing assisted conception treatment with gonadotropin-releasing hormone (GnRH) agonists and GnRH antagonists

Comparison of preovulatory follicular concentrations of epidermal growth factor, insulin-like growth factor-I, and inhibins A and B in women undergoing assisted conception treatment with gonadotropin-releasing hormone (GnRH) agonists and GnRH antagonists

Prediction of pregnancy in IVF cycles on the fourth day of ovarian stimulation

Estradiol Level on Day 2 and Day of Trigger: A Potential Predictor of the IVF-ET Success

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