Follicular fluid Lidocaine  levels during transvaginal oocyte retrieval

Bailey-Pridham, Dwight D.; Reshef, Eli; Drury, K.C.; Cook, Christine L.; Hurst, Harrell E.; Yussman, Marvin A.

doi:10.1016/s0015-0282(16)53237-3

Cited by 25 publications

(2 citation statements)

References 2 publications

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“…Our results suggest that the mean period of general anaesthesia per aspirated follicle, with the combination of sevoflurane, fentanyl and propofol, adversely affects ICSI outcome. Anesthetic agents have been proposed to reach the follicular fluid within minutes after administration, and may have deleterious effects on IVF outcomes (Bailey- Pridham et al, 1990;Imoedemhe et al, 1992;Soussis et al, 1995;Wikland et al, 1990). Hammadeh et al (Hammadeh et al, 1999) compared the effects of general anaesthesia (with propofol, remifentanil and isoflurane) versus sedation (with midazolam, diazepam, or propofol) on fertilization rate, cleavage rate and pregnancy rate.…”

Section: Discussionmentioning

confidence: 99%

The effects of general anaesthesia with sevoflurane on intracytoplasmic sperm injection outcomes

Setti¹,

Carlos²,

Braga³

et al. 2011

JBRA

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Objetivo‫׃‬ investigar os potenciais efeitos adversos da anestesia geral, utilizada para recuperação oocitária, nos resultados da injeção intracitoplasmática de espermatozóides (ICSI).Material e métodos‫׃‬ Um total de 444 ciclos de ICSI, em que uma combinação de fentanil, propofol e sevoflurano foi utilizada para anestesia geral durante a aspiração folicular, foram avaliados. Modelos de regressão foram utilizados para avaliar a influência do período médio de anestesia por folículo aspirado (∆T) nos resultados da ICSI. Os ciclos foram divididos em grupos de acordo com o ∆T, e os resultados da ICSI foram comparados entre os grupos. Resultados‫׃‬análise de regressão demonstrou uma correlação negativa entre o ∆T e a taxa de embriões de boa qualidade (Slope: -5,015, R2: 4,4%, p <0,001). O ∆T foi determinante para a diminuição da probabilidade de gravidez (OR: 0,77, IC: 0,64-0,93, p = 0,005) e transferência de embriões (OR 0,17, IC: 0,06-0,48, p = 0,001). Quando os ciclos foram divididos de acordo com o ∆T, diferenças significativas nas taxas de embriões de boa qualidade (55,6% e 44,2%, p = 0,001) e de gestação (58,2% vs 41,8%, p = 0,045) foram observadas para valores de ∆T ≤ 2 e> 2 min, respectivamente. Conclusão‫׃‬ nosso estudo sugere que a anestesia geral influencia negativamente o desenvolvimento do embrião e as taxas de gestação e de cancelamento de ciclo. Palavras-chave: ICSI; recuperação oocitária; anestesia.

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Section: Discussionmentioning

confidence: 99%

The effects of general anaesthesia with sevoflurane on intracytoplasmic sperm injection outcomes

Setti¹,

Carlos²,

Braga³

et al. 2011

JBRA

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“…There has been high scientific interest on the potential impact of anesthetic agents used in OR on oocyte fertilization and embryo quality. Drugs, such as propofol, thiopental, midazolam, fentanyl and alfentanil, along with local anesthetics, can accumulate in the follicular fluid and may affect oocyte structure and subsequent fetal development [13][14][15][16][17]. The assessment of their potential role on IVF success has yielded conflicting results.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Two Different Sedation Protocols during Transvaginal Oocyte Retrieval: Effects on Propofol Consumption and IVF Outcome: A Prospective Cohort Study

Matsota

Sidiropoulou

Vrantza

et al. 2021

JCM

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(1) Background: There has been various reports on the potential impact of anesthetic agents used during oocyte retrieval (OR) on the impairment of the capacity of the oocyte for fertilization and subsequent embryo quality; results have been conflicting; (2) Methods: The effects of two different sedation protocols during OR in two groups of patients undergoing In Vitro Fertilization/Intra-Cytoplasmic Sperm Injection IVF/ICSI, were compared on propofol consumption and on in vitro fertilization (IVF)/ICSI success. The study group received dexmedetomidine and fentanyl, while the control remifentanil and midazolam. In a prospective cohort study, we encompassed 72 cycles/patients. The administered dose of propofol per patient and fertilization rates were the primary outcomes, while anesthesiological parameters and IVF/ICSI outcomes were the secondary endpoints; (3) Results: We found a significant increase in propofol consumption in the study compared to the control group (77.0 ± 10.6 mg vs. 12.1 ± 6.1; p < 0.001), but fertilization rates were similar (p = 0.469). From the secondary anesthesiological outcomes, the post anesthesia discharge scores were better in the control group (15.0 (13.5 min) vs. 5.0 (10.0 min), p = 0.028). From the IVF/ICSI secondary outcome parameters, we found a higher quality of embryos on day three in the study compared to the control group (p = 0.040). The comparison of the other secondary outcomes yielded non-significant differences; (4) Conclusions: The use of dexmedetomidine, as an alternative agent during OR, was associated with higher propofol consumption as a rescue dose compared to remifentanil but was linked with similar fertilization rates and higher quality of embryos produced.

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Anesthesia in the Office

Beltsos¹

Office-Based Infertility Practice

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Follicular fluid Lidocaine levels during transvaginal oocyte retrieval

Cited by 25 publications

References 2 publications

The effects of general anaesthesia with sevoflurane on intracytoplasmic sperm injection outcomes

The effects of general anaesthesia with sevoflurane on intracytoplasmic sperm injection outcomes

Comparison of Two Different Sedation Protocols during Transvaginal Oocyte Retrieval: Effects on Propofol Consumption and IVF Outcome: A Prospective Cohort Study

Anesthesia in the Office

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