Follicular fluid vascular endothelial growth factor concentrations are elevated in women of advanced reproductive age undergoing ovulation induction

Friedman, Chad I.; Danforth, Douglas R.; Herbosa-Encarnacion, Cristina; Arbogast, Laura K.; Alak, Baha M.; Seifer, David B.

doi:10.1016/s0015-0282(97)00278-1

Cited by 106 publications

(76 citation statements)

References 17 publications

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“…Older women undergoing IVF have been shown to have higher follicular fluid VEGF levels, consistent with a hypoxic environment within follicles of older women [33]. Ovarian perifollicular vascularity correlates with follicular fluid oxygen content [9,34].…”

Section: Discussionmentioning

confidence: 95%

Power doppler ultrasound assessment of the relationship between age and ovarian perifollicular blood flow in women undergoing in vitro fertilization treatment

Costello

Shrestha

Sjöblom

et al. 2006

J Assist Reprod Genet

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Section: Discussionmentioning

confidence: 95%

Power doppler ultrasound assessment of the relationship between age and ovarian perifollicular blood flow in women undergoing in vitro fertilization treatment

Costello

Shrestha

Sjöblom

et al. 2006

J Assist Reprod Genet

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“…Once again, as in the case of the Young's modulus, the small change in tissue deformation with increase in permeability may be attributed to the fact that it is the interstitial expansion that is responsible for opening the sliding valve. Clinical studies show that in obesity [16], pregnancy [1,35] and in the elderly [17,29] vascular permeability increases. Furthermore that cases of oedema are common in patients who have a high vascular permeability [3,51].…”

Section: Parameter Influencementioning

confidence: 99%

A Model for Interstitial Drainage Through a Sliding Lymphatic Valve

2015

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This study investigates fluid flow and elastic deformation in tissues that are drained by the primary lymphatic system. A model is formulated based on the Rossi hypothesis that states that the primary lymphatic valves, which are formed by overlapping endothelial cells around the circumferential lining of lymphatic capillaries, open in response to swelling of the surrounding tissue. Tissue deformation and interstitial fluid flow through the tissue are treated using the Biot equations of poroelasticity and, the fluid flux, (into the interstitium) across the walls of the blood capillaries, is assumed to be linearly related to the pressure difference across the walls via a constant of proportionality (the vascular permeability). The resulting model is solved in a periodic domain containing one blood capillary and one lymphatic capillary starting from a configuration in which the tissue is undeformed. On imposition of a constant pressure difference between blood and lymphatic capillaries the solutions are found to settle to a steady state. Given that the magnitude of pressure fluctuations in the lymphatic system is much smaller than this pressure difference between blood and lymph it is postulated that the resulting steady state solution gives a good representation of the state of the tissue under physiological conditions. The effects of changes to the Young's modulus of the tissue, the blood-lymphatic pressure difference, vascular permeability and valve dimensions on the steady state are investigated and discussed in terms of their effects on oedema in the context of age-and pregnancy-related changes to the body.

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“…Patients with endometriosis or polycystic ovary syndrome were excluded because it is well known that these patients have higher intrafollicular VEGF levels than other infertile patients [8,9]. Patients aged more than 35 years were excluded as it has been reported that older patients may have higher intrafollicular VEGF levels than the younger patients [10].…”

Section: Subjectsmentioning

confidence: 99%

Follicular fluid VEGF levels directly correlate with perifollicular blood flow in normoresponder patients undergoing IVF

Monteleone

Artini

Simi

et al. 2008

J Assist Reprod Genet

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Follicular fluid vascular endothelial growth factor concentrations are elevated in women of advanced reproductive age undergoing ovulation induction

Cited by 106 publications

References 17 publications

Power doppler ultrasound assessment of the relationship between age and ovarian perifollicular blood flow in women undergoing in vitro fertilization treatment

Power doppler ultrasound assessment of the relationship between age and ovarian perifollicular blood flow in women undergoing in vitro fertilization treatment

A Model for Interstitial Drainage Through a Sliding Lymphatic Valve

Follicular fluid VEGF levels directly correlate with perifollicular blood flow in normoresponder patients undergoing IVF

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