Follicular growth in fetal and prepubertal ovaries of humans and other primates

Peters, Hannah; Byskov, Anne Grete; Grinsted, Jørgen

doi:10.1016/s0300-595x(78)80005-x

Cited by 127 publications

(61 citation statements)

References 43 publications

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“…Although the mechanism of oocyte selection is unclear, most of the recruited oocytes continue to grow until ovulation, and some of the growing follicles undergo degeneration (atresia) at various stages of folliculogenesis (Peters et al 1978).…”

Section: Discussionmentioning

confidence: 99%

Apoptosis in the Degeneration Process of Unferilized Mouse Ova.

Takase

Ishikawa

Hoshiai

1995

Tohoku J. Exp. Med.

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In mammals, ova which are not fertilized undergo degeneration. Thus, it seems that the ovum is programmed to die unless fertilization and embryogenesis occur, but little is known about the mechanism of such degeneration. To investigate this process, we observed the morphological changes of cultured unfertilized ova and stained DNA fragmentation by the modified TUNEL method (treating floating samples in liquid reagents) to detect apoptosis. Ova were collected from the oviducts of superovulated mice and cultured for observation. The number of morphologically abnormal ova with shrinkage of the ooplasm and cytoplasmic fragmentation, which are typical features of apoptosis, showed a significant gradual increase from 24 to 32 hr (p <0.05) and an abrupt increase from 40 hr of incubation (p <0.001). DNA fragmentation, which is one of the biological changes seen in apoptosis, was observed in the ooplasm of both intact and abnormal ova, cells with cytoplasmic fragmentation, and in the first polar body at the time of ovum collection as well as after incubation. These findings demonstrate that apoptosis is related to the process of degeneration in the mouse ovum and first polar body.

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Section: Discussionmentioning

confidence: 99%

Apoptosis in the Degeneration Process of Unferilized Mouse Ova.

Takase

Ishikawa

Hoshiai

1995

Tohoku J. Exp. Med.

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“…In contrast, in the rodent, the majority of follicles form and are recruited to grow to primary/more advanced follicles after birth, although there is emerging evidence that follicles start to form at 17.5 dpc (Pepling et al 2010). In both human and rodent species, follicle growth continues until the primordial follicle population is depleted (Peters et al 1978, Gougeon 1996.…”

Section: Organisation Of Follicular Structures In the Ovarymentioning

confidence: 99%

Mammalian foetal ovarian development: consequences for health and disease

Sarraj¹,

Drummond

2012

Reproduction

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The development of a normal ovary during foetal life is essential for the production and ovulation of a high-quality oocyte in adult life. Early in embryogenesis, the primordial germ cells (PGCs) migrate to and colonise the genital ridges. Once the PGCs reach the bipotential gonad, the absence of the sex-determining region on the Y chromosome (SRY) gene and the presence of female-specific genes ensure that the indifferent gonad takes the female pathway and an ovary forms. PGCs enter into meiosis, transform into oogonia and ultimately give rise to oocytes that are later surrounded by granulosa cells to form primordial follicles. Various genes and signals are implicated in germ and somatic cell development, leading to successful follicle formation and normal ovarian development. This review focuses on the differentiation events, cellular processes and molecular mechanisms essential for foetal ovarian development in the mice and humans. A better understanding of these early cellular and morphological events will facilitate further study into the regulation of oocyte development, manifestation of ovarian disease and basis of female infertility.

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“…Due to the low gonadotrophin levels present during this period of life many follicles undergo atresia (Skinner 2005). Considering the ovarian continuum, a healthy child is in an anovulatory state, although having a considerable pool of follicles in the ovaries (Peters, Byskov, and Grinsted 1978). Interestingly, during puberty, when gonadotrophin levels start to rise, primordial follicles that have developed to the antral stage will continue their development until one of them reaches the pre-ovulatory stage and ovulation occurs.…”

Section: Care Of Women In Various Stages Of Lifementioning

confidence: 99%

Ovulation, A Sign of Health

Vigil

Lyon²,

Flores³

et al. 2017

Linacre Q

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The concept of the ovarian continuum can be understood as a process that occurs during a woman's lifetime and begins during intrauterine life with fertilization. Women start their reproductive years with approximately five hundred thousand follicles containing oocytes, of which only around five hundred will be released during ovulation. Ovulation has been recognized as an event linked with reproduction; however, recent evidence supports the role of ovulation as a sign of health. The use of biomarkers that help women recognize ovulation enables them to identify their health status. This knowledge helps medical healthcare providers in the prevention, diagnosis, and treatment of different pathologies related with endocrine disorders, gynecological abnormalities, autoimmune, genetic, and neoplastic diseases, as well as pregnancy-related issues. The knowledge of the ovarian continuum and the use of biomarkers to recognize ovulation should be considered a powerful tool for women and medical professionals. Summary:The ovarian continuum is a process that occurs during a woman's lifetime. It begins during intrauterine life with fertilization and ends with menopause. This process can be greatly affected by different conditions such as changes in hormonal levels and illnesses. Therefore, understanding and promoting the knowledge and use of biomarkers of ovulation in women is a key aspect to consider when evaluating their health status. The knowledge and education about the ovarian continuum should be taken into account as a powerful tool for women and medical professionals.

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Follicular growth in fetal and prepubertal ovaries of humans and other primates

Cited by 127 publications

References 43 publications

Apoptosis in the Degeneration Process of Unferilized Mouse Ova.

Apoptosis in the Degeneration Process of Unferilized Mouse Ova.

Mammalian foetal ovarian development: consequences for health and disease

Ovulation, A Sign of Health

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