Follicular Helper T (Tfh) Cells in Autoimmune Diseases and Allograft Rejection

Jeon, Yun Hui; Choi, Youn Soo

doi:10.4110/in.2016.16.4.219

Cited by 12 publications

(10 citation statements)

References 123 publications

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“…Due to the observed increased proportion of T FH cells and the results of a previous study that showed enhanced B cell function in sheep RBC immunized mice (27), we hypothesized that there would be elevated levels of GC B cells. The inguinal lymph node cells were analyzed by flow cytometry.…”

Section: Resultsmentioning

confidence: 99%

“…T follicular helper (T FH ) cells, which express the CXCR5 and key transcription factor B-cell lymphoma 6 (Bcl-6), are localized in the GC in draining lymph nodes (25). T FH cells provide critical costimulatory signals and cytokines to B cell cognates, resulting in somatic mutation for affinity maturation and isotype-class switch (26272829).…”

Section: Introductionmentioning

confidence: 99%

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Curcumin Elevates T_FH Cells and Germinal Center B Cell Response for Antibody Production in Mice

2019

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Curcumin is a natural product extracted from Curcuma longa. It has been reported as a potent antioxidant and anti-inflammatory compound. Previous studies have demonstrated that curcumin suppresses pro-inflammatory cytokine production via inhibition of NF-κB in macrophages. However, its role in adaptive immune cells such as T cells, in vivo, has not clearly been elucidated. Here, we examined the effects of curcumin in T follicular helper (T FH) cells and on Ab production during NP-ovalbumin immunization in mice. The results revealed that curcumin administered daily significantly increased CXCR5 + B-cell lymphoma 6 + T FH cells and CD95 + GL-7 + germinal center (GC) B cells in draining lymph nodes. In addition, curcumin treatment in mice induced total Ab production as well as high affinity IgG1 and IgG2b Ab production. Collectively, these results suggest that curcumin has positive regulatory roles in T FH cell functions and GC responses. Thus, this could be an advantageous supplement to enhance humoral immunity against infectious diseases and cancer.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Curcumin Elevates T_FH Cells and Germinal Center B Cell Response for Antibody Production in Mice

2019

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“…B cell differentiation into autoantibody-secreting cells in these mice largely occurs at extrafollicular sites. Autoantibody production is supported by CD4 + T extrafollicular helper cells (T HEF ); these cells reside outside the B cell follicle and their gene expression profile resembles that of follicular helper T (T FH ) cells, although they express CXCR4 rather than CXCR54748. Yet, the mechanisms by which MSCs suppress B cell hyperactivity in MRL.…”

Section: Discussionmentioning

confidence: 99%

CCL2 deficient mesenchymal stem cells fail to establish long-lasting contact with T cells and no longer ameliorate lupus symptoms

Lee

Kim

et al. 2017

Sci Rep

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Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disease characterized by autoantibody production. Mesenchymal stem cells (MSCs) ameliorate SLE symptoms by targeting T cells, whereas the mechanisms of their efficacy remain incompletely understood. In this study, we show that transfer of human MSCs increased MRL.Faslpr mouse survival, decreased T cell infiltration in the kidneys, and reduced T cell cytokine expression. In vitro, allogeneic mouse MSCs inhibited MRL.Faslpr T cell proliferation and cytokine production. Time-lapse imaging revealed that MSCs recruited MRL.Faslpr T cells establishing long-lasting cellular contacts by enhancing T cell VCAM-1 expression in a CCL2-dependent manner. In contrast, CCL2 deficient MSCs did not induce T cell migration and VCAM-1 expression, resulting in insufficient cell-cell contact. Consequently, CCL2 deficient MSCs did not inhibit IFN-γ production by T cells and upon transfer no longer prolonged survival of MRL.Faslpr mice. Taken together, our imaging study demonstrates that CCL2 enables the prolonged MSC–T cell interactions needed for sufficient suppression of autoreactive T cells and helps to understand how MSCs ameliorate symptoms in lupus-prone MRL.Faslpr mice.

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“…Dysregulated B cell subpopulations were found in a variety of autoimmune diseases, such as IgG4related disease and primary Sjӧgren's syndrome (7). The production of high-a nity antibodies results from the interactions between B cells and T follicular helper (Tfh) cells; an increased number of circulating Tfh cells has been correlated with the severity of autoimmune diseases (8,9).…”

Section: Introductionmentioning

confidence: 99%

Abnormal B Cell Compartment Associated With Tfh Cells in Children With Henoch-schonlein Purpura

Zhang

Sun

Pan

et al. 2020

Preprint

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Aim IgA-producing B cells were found to be associated with children diagnosed with Henoch-Schonlein purpura (HSP). The present study aimed to determine whether children with HSP possess abnormal B cell subsets. Methods A total of 14 children diagnosed with HSP, and age- and gender-matched healthy controls were enrolled in our study. Peripheral blood mononuclear cells were isolated, and the percentage of B cells subsets and Tfh cells were determined by flow cytometry. Finally, Spearman’s correlation coefficient was used to analyze the correlation between the percentage of Tfh cells and B cell subsets. Results We found that the frequency of total B cells was significantly increased in children with HSP; however, the percentage of plasma cells was significantly lower in HSP children. A significant reduction in the count of naïve B cells and an increase in class-switched B cells were found in children with HSP compared with healthy controls. We observed that the expression of C-X-C chemokine receptor type 5 (CXCR5) on total CD4+ T cells and the percentage of CD4+CXCR5+ cells were significantly increased within HSP patients. Moreover, significant correlations between Tfh cells and various B cells subsets were observed. Conclusion Our study showed a Tfh cell-associated abnormal B cell compartment in HSP children.

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Follicular Helper T (Tfh) Cells in Autoimmune Diseases and Allograft Rejection

Cited by 12 publications

References 123 publications

Curcumin Elevates T_FH Cells and Germinal Center B Cell Response for Antibody Production in Mice

Curcumin Elevates T_FH Cells and Germinal Center B Cell Response for Antibody Production in Mice

CCL2 deficient mesenchymal stem cells fail to establish long-lasting contact with T cells and no longer ameliorate lupus symptoms

Abnormal B Cell Compartment Associated With Tfh Cells in Children With Henoch-schonlein Purpura

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Follicular Helper T (Tfh) Cells in Autoimmune Diseases and Allograft Rejection

Cited by 12 publications

References 123 publications

Curcumin Elevates TFH Cells and Germinal Center B Cell Response for Antibody Production in Mice

Curcumin Elevates TFH Cells and Germinal Center B Cell Response for Antibody Production in Mice

CCL2 deficient mesenchymal stem cells fail to establish long-lasting contact with T cells and no longer ameliorate lupus symptoms

Abnormal B Cell Compartment Associated With Tfh Cells in Children With Henoch-schonlein Purpura

Contact Info

Product

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Curcumin Elevates T_FH Cells and Germinal Center B Cell Response for Antibody Production in Mice

Curcumin Elevates T_FH Cells and Germinal Center B Cell Response for Antibody Production in Mice