Follicular Hybrid Cyst With Isthmic-Catagen, Pilomatrical, and Syringocystadenoma Papilliferum Components

Dargent, Jean‐Louis; Aupaix, F.; Hérin, Michel

doi:10.1097/dad.0b013e31825c72c1

Cited by 2 publications

(3 citation statements)

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“…In addition, Milman et al reported hybrid cysts with apocrine differentiation, displayed immunoreactivity to the CEA, suggesting an origin at the junction of the keratinizing squamous and glandular epithelia of the hair follicle. Pilomatricoma and steatocystoma, syringocystadenoma papilliferum, and verrucous growth of squamous epithelial components of follicular hybrid cysts have also been described.…”

Section: Discussionmentioning

confidence: 99%

“…Trichilemmal (or pilar) cysts are benign adnexal intradermal cysts that tend to occur on the scalp . Follicular hybrid cysts are rare, and contain two or more components of the epithelial skin adnexa . The remnants of many hair follicles and neoplasia can be seen in hybrid cysts .…”

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confidence: 99%

“…Follicular hybrid cysts are rare, and contain two or more components of the epithelial skin adnexa . The remnants of many hair follicles and neoplasia can be seen in hybrid cysts . Moreover, squamous cell carcinoma, high‐grade intraepithelial neoplasia (in an epidermoid cyst), Bowen's disease (in keratinous cysts), in situ carcinoma (in an epidermal cyst), in situ Merkel cell carcinoma (in a trichilemmal cyst), in situ trichilemmal carcinoma, in situ carcinoma (in a trichilemmal cyst), and epithelium composed of apocrine cells have been previously reported in the literature.…”

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confidence: 99%

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In situ carcinoma in a hybrid cyst: a case report

Başak

2016

J Cutan Pathol

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Follicular hybrid cysts including two or more components of the epithelial skin adnexa are very rare. The epithelial lining of hybrid cysts varies, and either contains epidermis, and trichilemmal squamous epithelium, or other epithelia of the skin adnexa. Hybrid cysts may also be associated with neoplasia, such as in situ carcinoma, Bowen's disease and squamous cell carcinoma. A 37-year-old female was complaining of a cyst on her scalp. The unilocular cystic lesion was lined with markedly atypical squamous cells with trichilemmal differentiation. Marked nuclear and cytological atypia, pleomorphism, numerous mitotic figures and atypical mitosis was detected in the squamous epithelium. The epithelium of the cyst was also composed of ductal structures lined with cuboidal epithelium. Immunohistochemical staining was positive for cytokeratin 7 (CK7) in both squamous and glandular epithelium. Luminal staining was shown by carcinoembryonic antigen (CEA), although gross cystic disease fluid protein-15 (GCDFP-15) was negative in the glandular epithelium. In addition, p16 tumor suppressor gene was strongly positive in both the squamous and glandular epithelium. Overall, the unique cystic lesion reported contained pilar squamous epithelium with in situ carcinoma and eccrine ductal structures, which was interpreted as a hybrid cyst composed of in situ trichilemmal carcinoma and a ductal eccrine component.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%