Follicular involvement in porokeratosis

Almeida, HL De; Guarenti, IM; Castro, Las De; Rocha, N. E. M.

doi:10.1111/j.1468-3083.2006.01798.x

Cited by 22 publications

(15 citation statements)

References 10 publications

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“…Another case report describes punctate follicular papules in the center of lesions of DSAP, for which biopsies demonstrated keratotic plugs within vellus follicles in the centers of lesional skin. 14 Interestingly, in our patient, subcorneal pustules arose within cornoid lamellae, and this correlated with the clinical finding of pustules within the annular scaly borders of lesions. To our knowledge this has not been previously described.…”

Section: Discussionsupporting

confidence: 84%

Pustular porokeratosis

Miller¹,

Ruben

2009

J Cutan Pathol

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We report a case of disseminated superficial actinic porokeratosis (DSAP) with neutrophilic pustules within cornoid lamellae on histopathologic examination, corresponding to pustules along the elevated rim clinically as well. A review of the literature identified only one other case in which pustules have been associated with porokeratosis. Our case represents an unusual variant of DSAP, which may make an ordinarily straightforward clinical diagnosis more challenging.

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Section: Discussionsupporting

confidence: 84%

Pustular porokeratosis

Miller¹,

Ruben

2009

J Cutan Pathol

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“…In another report of two cases, both revealed follicular localization of parakeratotic lamellae. 6 In one, a 43‐year‐old female with DSAP, lesions were on sun‐exposed areas, whereas in the other, a 45‐year‐old female with PM, lesions were large and either photo‐ and non‐photo‐distributed. More recently, Young et al 5 reported a case of follicular PM on the buttocks of a 42‐year‐old male.…”

Section: Discussionmentioning

confidence: 99%

“…Follicular involvement by porokeratosis is rare but has been described in conjunction with PM and DSAP. 4–6 In this report we present a case of porokeratosis in which clinically, the lesions were found in sun‐ and non‐sun‐exposed areas and were follicle‐centered, and the histologically unifying feature in multiple biopsies was the presence of cornoid lamellae overlying the follicle.…”

Section: Introductionmentioning

confidence: 89%

Follicular porokeratosis: distinct clinical entity or histologic variant?

2009

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Various clinical subtypes of porokeratosis, clinically characterized by annular plaques with a normal or atrophic center and a distinctive keratotic ridge, are described based on the age of onset, size, number and distribution of the lesions. Follicular involvement, identified by follicular localization of cornoid lamellae, is uncommon and has only been reported in association with other subtypes such as disseminated superficial actinic porokeratosis and porokeratosis of Mibelli. We present a case of follicular porokeratosis in a 40-year-old male who presented initially with scaly red "papules" in a follicular distribution on the upper extremity. Microscopic examination of a punch biopsy specimen revealed parakeratosis confined to the follicle and mild interface change. A repeat biopsy performed in 2008 revealed identical histologic features. In terms of etiopathogenesis, a clone of cells at the base of the follicle demonstrating abnormal keratinization is not a novel concept and has been demonstrated in other porokeratotic dermatoses. However, the presence of lesions that are solely follicular based, in terms of clinical presentation and histologic findings, and static over a 3-year period favors the concept that follicular porokeratosis is a distinct clinical entity and not merely a histologic variant of the porokeratotic dermatoses described in the literature thus far.

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“…An autosomal dominant inheritance pattern with incomplete penetrance is most commonly reported. [1][2][3][4][5] In these cases, the abnormal clonal proliferation of keratinocytes that spreads radially to form the cornoid lamella penetrates the "innocent bystander" hair follicles. 8,9 Other pathophysiologic factors may also be important.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5] An additional case reported punctate porokeratosis emanating from a hair follicle with no associated annular cornoid lamella. A number of clinical variants have been identified, including porokeratosis of Mibelli (PM), disseminated superficial actinic porokeratosis (DSAP), linear porokeratosis, porokeratosis palmaris et plantaris disseminata, and punctate porokeratosis.…”

Section: Introductionmentioning

confidence: 99%

Punctate Follicular Porokeratosis

Trikha

Wile²,

King

et al. 2015

The American Journal of Dermatopathology

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Porokeratosis is a disorder of keratinization characterized by an abnormal cornoid lamella surrounding an annular, scaly plaque with an atrophic center. A histologic variant of this condition has been proposed, termed follicular porokeratosis, in cases where follicular involvement was contiguous with an annular cornoid lamella. There has been only 1 report of punctate follicular porokeratosis, in which cornoid lamellae originated exclusively from hair follicles with no associated annular plaque. The authors present the second case of punctate follicular porokeratosis, further supporting the contention that this entity is a unique form of porokeratosis rather than a histologic variant. A 56-year-old African American female presented to the dermatology clinic with a 3-month history of keratotic lesions localized on the right posterior shoulder. Examination revealed an area of perifollicular keratotic papules, each surrounded by an erythematous rim. Histopathology revealed a cornoid lamella originating within a hair follicle, with the parakeratotic column protruding through the follicular orifice. The static nature of the condition along with exclusive involvement of hair follicles supports the notion of punctate follicular porokeratosis as a distinct clinical entity. The diagnosis of this condition relies heavily on proper histopathologic sampling revealing punctate follicular cornoid lamellae.

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Follicular involvement in porokeratosis

Cited by 22 publications

References 10 publications

Pustular porokeratosis

Pustular porokeratosis

Follicular porokeratosis: distinct clinical entity or histologic variant?

Punctate Follicular Porokeratosis

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