Follicular lymphoma.A re-evaluation of its position in the scheme of malignant lymphoma based on a survey of 253 cases

Transformed lymphoma: an Achilles' heel of non-Hodgkin's lymphoma

“…At the Armed Forces Institute of Pathology, Rappaport classified 253 cases of follicular lymphoma based on histologic pattern and clinical correlation. 2 Rappaport noted the favorable prognosis of follicular (nodular) architecture over diffuse, as well as the tendency of follicular lymphomas to progress into diffuse lymphomas, typically of the corresponding cell type. In agreement with these observations, HT is commonly interpreted as loss of follicular architecture and evolution toward a larger, less differentiated cell type such as diffuse mixed or diffuse large-cell lymphoma (Table 1).…”

“…1,2 Despite attempts to further characterize histologic transformation (HT), there is still much uncertainty as to what constitutes transformation, its true incidence, risk factors for transformation, and optimal treatment.…”

Complement Receptor Subtypes C3b and C3d in Lymphatic Tissue and Follicular Lymphoma

“…Later studies established their neoplastic nature (Callender, 1934;Gall et al, 1941;Wright, 1956). Rappaport et al (1956) maintained that there was no conclusive evidence for the contention that the so-called follicles of follicular lymphoma arose from, or were related to, reactive germinal centres. Because of the morphological variations observed within this lymphoma group, these authors considered the nodular growth pattern to be an architectural variant that could be seen in any of the histological types of non-Hodgkin's lymphoma.…”

Lymphoma classification and the tools of our trade: an introduction to the 2012 USCAP Long Course

“…' This review begins with the Rappaport classification, initially published in 1956 in a publication on follicular lymphomas (Table 1). 4 It was officially published with some changes in Dr Rappaport's AFIP fascicle in 1966 including the famed but flawed change to histiocytic from reticulum cell for the large-cell lymphomas and the introduction of an undifferentiated category. 5 This strictly morphological classification had five and then eight categories and required subsequent distinction of diffuse and nodular ('follicular') growth patterns.…”