Follicular Neoplasm/Suspicious for a Follicular Neoplasm

Outcome of thyroid gene expression classifier testing in clinical practice

“…Cytology that was determined unsatisfactory by the cytopathologist on first pass was immediately repeated with additional passes until adequacy for diagnosis was obtained. If the FNAC was indeterminate, Bethesda Classification III or IV, two additional passes were obtained with ultrasound guidance and placed in the FNAProtect solution for Afirma GEC testing.…”

“…Unnecessary surgeries are costly and result in unnecessary anxiety and risk for the patient, including surgical complications, unplanned hospital readmission, and though rare, perioperative death. The indeterminate FNAC categories routinely tested by the Afirma GEC include Bethesda III (atypia of undetermined significance/follicular lesion of undetermined significance [AUS/FLUS]) and Bethesda IV (follicular neoplasms/suspicious for follicular neoplasm [FN/SFN]) …”

Diagnostic criteria and risk‐adapted approach to indeterminate thyroid cytodiagnosis

“…3 In addition, I believe that the term ''microfollicular neoplasm'' does not necessarily add significant clarification to ''follicular neoplasm'' which, in the Bethesda System, refers to a cellular aspirate comprising follicular cells arranged in an altered architectural pattern characterized by significant cell crowding and/or a microfollicle formation with scant or no colloid. 4 The adopted Bethesda term emphasizes but does not limit the use of the diagnostic entity to those lesions with a microfollicular pattern, given that some follicular neoplasms (especially those proven to be follicular carcinomas on histological examination) may present as syncytial clusters and single cells without obvious microfollicles. 5 Hypercellular smears of macrofollicles are not considered to be an altered architectural pattern and, therefore, should not be of concern as long as there are no nuclear features of papillary thyroid carcinoma identified.…”

Fine-Needle Aspiration with Immunohistochemistry Using a Modified Scrape Cell Block Technique for the Diagnosis of Thyroid and Parathyroid Nodules

“…In cytology, parathyroid cells look very similar to cells of a microfollicular, noncolloidal thyroid nodule and may suggest a thyroid neoplasm [6,7,8]. When submitted as a thyroid FNA specimen, parathyroid adenomas (PA) tend to be misinterpreted as a follicular neoplasm or suspicious for a follicular neoplasm according to category IV of the Bethesda System for Reporting Thyroid Cytopathology [7].…”

“…When submitted as a thyroid FNA specimen, parathyroid adenomas (PA) tend to be misinterpreted as a follicular neoplasm or suspicious for a follicular neoplasm according to category IV of the Bethesda System for Reporting Thyroid Cytopathology [7]. The cytological outcome may be considered indicative of a parathyroid nodule only when all of the cells of the microfollicular groups are significantly smaller than thyroid cells [9].…”