Follicular T-cell lymphoma: a short review with brief discussion of other nodal lymphomas/lymphoproliferative disorders of T-follicular helper cell origin

Ramos, Josean; Ward, Nicholas

doi:10.1007/s12308-021-00460-w

Cited by 2 publications

(2 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Two molecular subtypes, PTCL-BX21 and PTCL-GATA3, which resemble T-helper type 1 (Th1) and Th2 cells, respectively, have been identified [ 69 ]. According to clinical studies, the PTCL-GATA3 subgroup’s prognosis is worse, and its genetics are usually complex [ 81 ]; conversely, the PTCL-TBX21 subgroup is characterized by a relatively better prognosis, fewer copy number alterations, and more mutations in the genes that regulate DNA methylation [ 81 ].…”

Section: Other Peripheral T-cell and Nk-cell Lymphomasmentioning

confidence: 99%

“…A provisional immunohistochemistry-based technique evaluating TBX21, CXCR3, GATA3, and CCR4 is used to classify these subgroups [ 69 ]. According to WHO-HAEM5, PTCL-GATA3 has a uniform molecular genetic profile, while PTCL-TBX21 is heterogeneous and may include a subgroup with a cytotoxic gene expression program and aggressive behavior [ 69 , 81 ]. The genetic context, clinicopathological context, and prognostic implications of these possible biological variants of PTCL-NOS are currently not well enough understood to warrant a formal designation as a separate “subtype”.…”

Section: Other Peripheral T-cell and Nk-cell Lymphomasmentioning

confidence: 99%

See 1 more Smart Citation

A Comparison of the Fifth World Health Organization and the International Consensus Classifications of Mature T-Cell Lymphomas

Piccaluga,

Khattab

2023

IJMS

View full text Add to dashboard Cite

Peripheral T-cell lymphomas (PTCLs) are a rare subset of non-Hodgkin lymphomas that often carry significant difficulty in diagnosis and classification because of their rarity and biological complexity. Previous editions of the World Health Organization (WHO) classifications of hemopoietic neoplasms in 2001, 2008, and 2017 aimed to standardize hemopoietic neoplasm diagnosis in general. Since then, crucial clinico-pathological, immunophenotypic, and recent molecular discoveries have been made in the field of lymphomas, contributing to refining diagnostic criteria of several diseases, upgrading entities previously defined as provisional, and identifying new entities. In 2022, two different models were proposed to classify hematolymphoid neoplasms: the 5th edition of the WHO classification (WHO-HAEM5) and the International Consensus Classification (ICC). Of note, a common nosography is mandatory to ensure progress in health science and ensure the basis for a real precision medicine. In this article, the authors summarized the main differences with the previous fourth WHO edition and reviewed the main discrepancies between the two newest classifications, as far as PTCLs are concerned.

show abstract

Section: Other Peripheral T-cell and Nk-cell Lymphomasmentioning

confidence: 99%