Follicular Variant of Papillary Carcinoma Presenting as a Hyperfunctioning Thyroid Nodule

Gabalec, Filip; Svilias, Ioannis; Plášilová, Ivana; Hovorková, Eva; Ryška, Aleš; Horáček, J

doi:10.1097/mph.0000000000000036

Cited by 10 publications

(6 citation statements)

References 2 publications

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“…In fact, the risk of a malignant evolution over time is not negligible, as also suggested by the several cases of primary thyroid carcinoma that were recently described in children suffering from HTNs [78][79][80][81].…”

Section: Hyperfunctioning Thyroid Nodulesmentioning

confidence: 91%

Management of hyperthyroidism in children

Luca

Salzano

Zirilli

et al. 2016

Expert Review of Endocrinology & Metabolism

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Treatment of hyperthyroidism in children differs according to its etiology; in particular, the optimal therapy of Graves' disease (GD) remains a matter of debate and there is currently no evidence-based therapeutic strategy that is universally adopted in all the countries. Areas covered: The most recent treatment strategies in the different pediatric conditions which may be associated with hyperthyroidism. We searched PubMed and Cochrane (1990 to 2016) in order to identify articles to include in this review using the following terms: Hyperthyroidism, Childhood, Antithyroid drug therapy, Thyroidectomy, Radioactive iodine. Expert commentary: Although pharmacological therapy represents the first-line approach for GD children, we recommend to individualize, as much as possible, the overall therapeutic approach, with no prejudices towards radical therapies, particularly in the cases with frequent relapses. Clinical and laboratory preferential criteria for an individualized therapeutic approach to GD children are given. Treatment procedures for hyperthyroid children without GD are also discussed.

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Section: Hyperfunctioning Thyroid Nodulesmentioning

confidence: 91%

Management of hyperthyroidism in children

Luca

Salzano

Zirilli

et al. 2016

Expert Review of Endocrinology & Metabolism

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“…Notably, however, one of these three patients also harbored thyroid cancer. Additionally, in recent years, there have been several other case reports of incidental detection of hot nodules in children [29][30][31].…”

Section: Thyroid Cancer In Functional Nodulesmentioning

confidence: 99%

Marine-Lenhart syndrome in two adolescents, including one with thyroid cancer: a case series and review of the literature

Sharma

2017

Journal of Pediatric Endocrinology and Metabolism

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Background: The coexistence of functional thyroid nodules and Graves' disease (GD) is a rare condition known as Marine-Lenhart syndrome. Thyroid cancer has been described in several adults, but never in children, with Marine-Lenhart syndrome. This paper discusses the challenges in diagnosis and the unique management of this condition in children, in the context of extant literature. Content: In this case report, two adolescent female patients with Marine-Lenhart syndrome, aged 15 and 16 years, exhibited biochemical evidence of hyperthyroidism, and were found to have unilateral hyperfunctioning thyroid nodules via thyroid scintigraphy. Additionally, both patients showed elevated thyroid-stimulating immunoglobulins (TSI) and increased glandular activity, confirming background GD. Notably, one patient was also diagnosed with intranodular thyroid cancer upon preoperative examination. Both patients were treated via surgical resection. Summary and outlook: Diagnosis of Marine-Lenhart syndrome can be made in patients with functional thyroid nodules and increased glandular activity on thyroid scintigraphy. Standard doses of radioiodine ablation are not effective in the majority of patients and should be avoided due to the increased risk for thyroid cancer, making thyroidectomy the preferred treatment.

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“…«Фолликулярные опухоли» (ФО) представляют собой аденомы фолликулярного строения без признаков инвазии капсулы и(или) сосудов. Данная группа новообразований объединена у многих авторов под термином «фолликулярная пролиферация», или «фолликулярная опухоль» [1, 4, 7], в которую другие включают также фолликулярный вариант папиллярного рака (ПР) и даже пролиферацию фолликулярного эпителия в зобе [7,14].…”

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“…Учитывая трудности предоперационной цитологической оценки ФО, многие отечественные и зарубежные авторы считают обоснованной активную хирургическую тактику со срочным гистологическим исследованием [9]. Однако единых взглядов на тактику диагностики и лечения данной категории больных до настоящего времени не выработано [1-4, [12][13][14].…”

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Diagnostic and Treatment Strategy in Follicular Tumor of Thyroid Gland

2015

VESTNIK KHIRURGII IMENI I.I.GREKOVA

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The article is based on the treatment results of 44 patients with follicular tumor of thyroid gland. A staged morphological assessment of thyroid nodes was performed for all patients: in case of preoperative fine-needle biopsy, urgent intraoperative study and according to results of final histological research. The urgent histological study of surgical material was conducted for 44 patients with diagnosis «follicular tumor» according to fine-needle biopsy. The data of final histological study were matched with findings of intraoperative research. A micro-follicular adenoma was detected in 22 patients (50%) and 6 (13,6%) patients had this diagnosis combined with autoimmune thyroiditis. The general part of patients didn’t changed in final study, but the rate of diagnosis «micro-follicular adenoma against the background of autoimmune thyroiditis» increased. Papillary carcinoma was revealed in 5 (11,4%) patients and follicular cancer had 4 (9,1%) patients detected in intraoperative study and 3 (6,8%) more patients according to data of final research. The histopathologic feature of colloid goiter was observed in 7 (15,9%) cases and a part of such patients reduced to 6,8% during final study. One of the patients (2,3%) had final diagnosis «oncocytoma». In case of thyroid nodules detection the needle biopsy should be carried out regardless to the size of nodule. The authors recommended performing the surgery with the urgent histological study in case of undetermined histological report. The following surgical strate gy was specified by the results of the urgent histological report.

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Follicular Variant of Papillary Carcinoma Presenting as a Hyperfunctioning Thyroid Nodule

Cited by 10 publications

References 2 publications

Management of hyperthyroidism in children

Management of hyperthyroidism in children

Marine-Lenhart syndrome in two adolescents, including one with thyroid cancer: a case series and review of the literature

Diagnostic and Treatment Strategy in Follicular Tumor of Thyroid Gland

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