Follicular Variant of Papillary Thyroid Carcinoma

Shih, Shyang-Rong; Shun, Chia‐Tung; Su, Deng-Huang; Hsiao, Yung-Lien; Chang, Tien–Chun

doi:10.1159/000326170

Cited by 32 publications

(6 citation statements)

References 4 publications

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“…But these features were not retained in some of the smears; this difference is possibly related to fixation techniques. [23] Diagnosis of FVPTC could be missed in the absence of characteristic nuclear features of PTC even though presence of high cellularity, microfollicular pattern and less colloid favors diagnosis of follicular neoplasm. [202324] In our study, we diagnosed two cases of FVPTC but missed diagnosis in three cases because of the absence of nuclear features.…”

Section: Discussionmentioning

confidence: 99%

A cell pattern approach to interpretation of fine needle aspiration cytology of thyroid lesions: A cyto-histomorphological study

Bommanahalli

Bhat

Rupanarayan

2010

J Cytol

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Aim:Our study aimed at a cell pattern approach to interpret thyroid cytology and to demonstrate diagnostic accuracy of fine needle aspiration cytology (FNAC) with an emphasis on diagnostic pitfalls.Materials and Methods:A total number of 218 goitre cases, from the year 2000 to 2004, were reviewed retrospectively from the cytology files, without considering the previous cytological diagnosis. Four cases with inadequate aspirate were excluded. The predominant cell pattern, such as macro/normofollicular, microfollicular, papillary, syncytial, dispersed and cystic pattern, was noted in each case. The final diagnosis was arrived by observing the cellular details and background elements. Cytological diagnosis was correlated with histopathology in 75 cases. The sensitivity and specificity were computed.Results:Normo/macrofollicular pattern was seen in 71.96% of nodular goitre and 6.9% of follicular neoplasms. Around 86.2% of follicular neoplasms and 17.6% of papillary carcinoma had microfollicular pattern. The papillary pattern was seen in 47% of papillary carcinoma. Syncytial pattern was noticed in 72.3% of chronic lymphocytic thyroiditis and 29.4% of papillary carcinoma. Cytological diagnosis was concordant with histopathological diagnosis in 65 cases. Overall sensitivity and specificity of FNAC in diagnosing neoplastic lesions of thyroid were 83.33 and 95.55%, respectively.Conclusion:FNAC is more sensitive and specific in triaging neoplastic from non-neoplastic thyroid lesions. Identification of the predominant cell pattern would be complementary to analysis of cell morphology and background details in cytological diagnosis of thyroid lesions. This approach helps to diagnose follicular neoplasm and follicular variant of papillary thyroid carcinoma.

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Section: Discussionmentioning

confidence: 99%

A cell pattern approach to interpretation of fine needle aspiration cytology of thyroid lesions: A cyto-histomorphological study

Bommanahalli

Bhat

Rupanarayan

2010

J Cytol

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“…Later on, he published a series of articles on the cytologic presentation of non-neoplastic thyroid diseases, such as Hashimoto’s thyroiditis [ 5 ], acute suppurative thyroiditis [ 6 ], and granulomatous thyroiditis [ 7 ], as well as thyroid carcinomas, such as papillary carcinoma [ 8 ] and anaplastic carcinoma [ 9 ] in the same journal. With these experiences from local practice, he started to publish articles in international journals in 1989 [ 10 - 22 ]. An anecdote about him is that he performs thyroid FNA while holding the needle like a Chinese brush pen [ 10 ].…”

Section: The History Of Thyroid Fine-needle Aspiration In Taiwanmentioning

confidence: 99%

Thyroid Fine-Needle Aspiration in Taiwan: The History and Current Practice

Hang

Hsu

Lai³

2017

J Pathol Transl Med

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In Taiwan, thyroid cancer is the most common endocrine gland malignancy and the incidence of thyroid cancer has increased four-fold in the past two decades. Fine-needle aspiration is an accurate and cost-effective method of evaluating thyroid nodules and has been the gold-standard diagnostic tool for thyroid tumors in Taiwan since the 1980s. This article reviews the history, current practice, reporting systems, training, and quality assurance for thyroid fine-needle aspiration cytology in Taiwan.

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“…It was well known that the follicular variant of PTC showed low sensitivity for FNA compared with conventional PTC. 25 Therefore, in this study, the proportion of the follicular variant (25 of 41 [61.0%]) was higher than that of conventional PTC (13 of 41 [31.7%]) in the final pathologic results compared with the initial FNA population. In addition, the proportion of the follicular variant was higher in false-negative cases (10 of 12 [83.3%]), because the follicular variant could be confused with benign or neoplastic follicular lesions due to its follicular growth pattern with a variable colloid component.…”

Section: Discussionmentioning

confidence: 55%