Follicule to Follicule Heterogeneity of Sebum Excretion

Piérard, G.E.

doi:10.1159/000249220

Cited by 52 publications

(27 citation statements)

References 4 publications

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“…These areas where the lipids accumulate become transparent to light [7]. The number and size of lipid droplets can be graded visually or by computer-based image analysis [8,9]. The latter was done for this study.…”

Section: Sebum Measurementmentioning

confidence: 99%

The 1,450‐nm diode laser reduces sebum production in facial skin: A possible mode of action of its effectiveness for the treatment of acne vulgaris

2007

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Background and Objectives: Over the last several years, several light-based systems have been employed for the treatment of acne vulgaris. The 1,450-nm diode laser has been shown to improve acne, and this has been suggested to be due to effects on sebaceous glands. However, an effect on sebum production has not been demonstrated. The objective of this study was to evaluate if the 1,450-nm diode laser indeed reduces sebum production. Study Design/Materials and Methods: Eight patients with a history of acne were recruited and treated with the 1,450-nm diode laser on the right side of the nose over a 6-week period, for a total of three treatments. Sebum production was quantified using the Sebutape method. Results: The number of sebum-producing follicles was reduced by 8.5 and 16.7% at weeks 4 and 6, respectively (P<0.05). A significant reduction in total collected sebum (À18%) was observed at week 6. Conclusion: This data suggests that the clinical effectiveness of the 1,450-nm diode laser may be based, at least in part, on its effects on sebaceous glands, with subsequent reduction in sebum production.

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Section: Sebum Measurementmentioning

confidence: 99%

The 1,450‐nm diode laser reduces sebum production in facial skin: A possible mode of action of its effectiveness for the treatment of acne vulgaris

2007

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“…Almost 15 years ago, progress was made simultaneously by two research teams introducing a method using standardized hydrophobic lipid-absorbent tapes [44][45][46] made of an opaque, open-celled, microporous polymeric film. Since its introduction, it has always been considered as complementary and as useful as the popular photometric method [19,[47][48][49][50].…”

Section: Lipid-sensitive Tapementioning

confidence: 99%

“…The method allows those without sophisticated equipment to obtain a rough but reasonable estimate of the skin greasiness. Better quantitative evaluation is achieved using computerized image analysis [46,[48][49][50]52], transmission photometry [47] or reflectance colorimetry [53,54].…”

Section: Lipid-sensitive Tapementioning

confidence: 99%

EEMCO Guidance for the in vivo Assessment of Skin Greasiness

Pierard

Piérard-Franchimont

Marks

et al. 2000

Skin Pharmacol Physiol

140

119

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Sebaceous gland activity has four distinct components which are sebum production (a secretion rate function), storage (a volume function), surface output (a delivery rate function) and stratum corneum permeation (an influx rate function). The oily appearance of skin results from an excess of sebum excretion and spreading over the body surface and its interaction with the skin surface. A multi-pronged approach is often useful to assess skin greasiness with precision. The clinical evaluation of skin greasiness and its shiny appearance should be further complemented by quantifying the large pores, follicular plugs and comedones. The sebum amount present at the skin surface can be measured non-invasively using one of several methods based on solvent extraction, cigarette paper pads, photometric assessment, bentonite clay and lipid-sensitive tapes. Quantitative parameters include the sebum casual level, the sebum excretion rate, the sebum replacement time, the instant sebum delivery, the follicular excretion rate, the density in sebum-enriched reservoirs and the sustainable rate of sebum excretion. A series of environmental and biological features influence the data. Hence rigorous methodological designs are mandatory to support claims. As a rule, accuracy of the methods is adversely affected by skin temperature, degree of hydration and surface roughness. An additional confounding factor is the inherent difficulty of collecting the surface lipids without a contribution from the follicular reservoir. A better understanding of factors that alter the sebum amount at the skin surface may well assist in the development of sebosuppressive agents to help the reduction of the skin greasiness and improve acne.

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“…This intriguing observation incited Harms [368] to propose a new concept: the ‘heterogeneity of sebaceous follicles'. Few years before, Piérard [369] had shown intraindividual and interindividual variations on the number of active sebaceous follicles. In fact, wrote Piérard, many of the sebaceous glands are ‘quiescent or barely active'.…”

Section: From Vitamin a To Isotretinoin: Innovative Views On Acne Patmentioning

confidence: 99%

“…For a given amount of sebum, the excretion varied from gland to gland suggesting the existence of ‘acne-prone' follicles. Little evidence explains however why only 1-3% of sebaceous follicles show acne in acne-prone people [369,370]. …”

Section: From Vitamin a To Isotretinoin: Innovative Views On Acne Patmentioning

confidence: 99%

Acne Pathogenesis: History of Concepts

Tilles¹

2014

Dermatology

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From the first reliable descriptions of acne in the early 19th century, dermatologists recognized it as a disease of the pilosebaceous follicle. Until the middle of the 20th century, they hypothesized that seborrhoea, follicular keratosis and microorganisms could be individually responsible for the acne lesions. Inflammation was only regarded as the final and inescapable step of the acne process. Although the importance of these factors has been reevaluated, recent works still regarded them as mandatory. In the 1970s, the onset of isotretinoin dramatically improved acne management. It also provided great opportunities for a better understanding of the pathogenic factors of acne. This study analyzes their genesis and development from the seminal contributions until recent advances.

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Follicule to Follicule Heterogeneity of Sebum Excretion

Cited by 52 publications

References 4 publications

The 1,450‐nm diode laser reduces sebum production in facial skin: A possible mode of action of its effectiveness for the treatment of acne vulgaris

The 1,450‐nm diode laser reduces sebum production in facial skin: A possible mode of action of its effectiveness for the treatment of acne vulgaris

EEMCO Guidance for the in vivo Assessment of Skin Greasiness

Acne Pathogenesis: History of Concepts

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