Folliculitis decalvans: Effectiveness of therapies and prognostic factors in a multicenter series of 60 patients with long-term follow-up

Miguel‐Gomez, Laura; Rodrigues-Barata, Ana Rita; Molina-Ruiz, Ana María; Martorell, A.; Fernández‐Crehuet, Pablo; Grimalt, Ramón; Barco, D.; Arias‐Santiago, Salvador; Serrano-Falcón, C.; Camacho, Francisco; Saceda‐Corralo, David; Jaén‐Olasolo, Pedro; Vañó‐Galván, Sergio

doi:10.1016/j.jaad.2018.05.1240

Cited by 56 publications

(107 citation statements)

References 16 publications

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“…A long‐term review will be required as folliculitis decalvans is prone to relapse following the regime that we have pursued. Further relapses may need the addition of other modes of therapy such as oral isotretinoin, photo‐dynamic therapy (PDT), oral corticosteroids, Nd:YAG laser, dapsone, finasteride and hydroxychloroquine …”

Section: Discussionmentioning

confidence: 99%

Folliculitis decalvans‐like pustular plaques on the limbs sparing the scalp

2019

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Folliculitis decalvans is a neutrophilic cicatricial alopecia characterised by progressive pustular folliculitis. Folliculitis decalvans is seen as a condition usually limited exclusively to the scalp and rarely affects the limbs. We present a case of a 63‐year‐old man with a 3‐year history of progressive pustular folliculitis with inflammatory patches and central scarring alopecia on both forearms and a circumscribed patch on his right lower leg. His presentation, clinical course and isolation of Staphylococcus aureus together with the histopathological findings all supported a folliculitis decalvans‐like pustular folliculitis limited to the limbs. Biopsies revealed follicular pustules, gross interfollicular fibrosis with plasma cells and concentric perifollicular fibrosis with lymphocytes, all features seen with folliculitis decalvans. The positive response to antibiotics combined with topical corticosteroids mirrored the response seen with scalp folliculitis decalvans. In contrast to the previously reported cases, the patient had no evidence of folliculitis decalvans on the scalp.

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Section: Discussionmentioning

confidence: 99%

Folliculitis decalvans‐like pustular plaques on the limbs sparing the scalp

2019

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“…Topical and oral antibiotics are the mainstay of treatment; however, response is variable and often unsatisfactory. In a multicenter study including 60 patients, Miguel-Gómez et al [12] proposed a tailored therapy based on patients' clinical conditions. Incisional biopsy is required to make a diagnosis; however, evaluation of the disease severity through consecutive biopsies is often rejected by patients and bear significant practical and economic implications, and thus is not recommended.…”

Section: Discussionmentioning

confidence: 99%

Reflectance Confocal Microscopy Applied to Folliculitis Decalvans: Preliminary Results of a Multicenter Study

Mazzilli

Vollono

Tassone

et al. 2020

Skin Appendage Disord

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Although trichoscopic criteria indicative of disease severity and inflammatory activity have been recently proposed, the potential use of reflectance confocal microscopy (RCM) in the evaluation of the inflammatory stage of FD has never been published to date. Our study investigated RCM features of 14 patients with a histopathological diagnosis of FD, evaluating clinical and trichoscopic findings. RCM findings were divided into 2 main patterns: “follicular” and “interfollicular.” Our results suggest a potential role for RCM as a noninvasive, fast technique for a complementary investigation in the diagnostic process, as well as in the therapeutic management decision.

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“…Folliculitis decalvans (FD) is a chronic disease involving inflammation and infection with an abnormal subepidermal microbiota 3 . Currently, treatments with tetracycline, rifampicin, and clindamycin are the most effective options 4,5 . In addition, prednisone, isotretinoin, and human immunoglobulin have been reported for the treatment of FD.…”

Section: Discussionmentioning

confidence: 99%

Aminolevulinic acid photodynamic therapy for folliculitis decalvans: A case report

Lin

Zhou

Wang

et al. 2020

Dermatologic Therapy

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Folliculitis decalvans (FD) is a chronic inflammatory disease with an unknown etiology. FD is characterized by chronic suppurative folliculitis, is often accompanied by pruritus or even pain, and ultimately progresses to cicatricial alopecia. Adult men have a tendency to develop this disease. The current treatments mainly consist of antibiotics, vitamin A derivatives, immune therapies, and biologics. However, some cases are intractable. Here, we present a case of recalcitrant FD that was successfully treated by photodynamic therapy with topical aminolevulinic acid.

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Folliculitis decalvans: Effectiveness of therapies and prognostic factors in a multicenter series of 60 patients with long-term follow-up

Cited by 56 publications

References 16 publications

Folliculitis decalvans‐like pustular plaques on the limbs sparing the scalp

Folliculitis decalvans‐like pustular plaques on the limbs sparing the scalp

Reflectance Confocal Microscopy Applied to Folliculitis Decalvans: Preliminary Results of a Multicenter Study

Aminolevulinic acid photodynamic therapy for folliculitis decalvans: A case report

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