Folliculo-sebaceous cystic hamartoma is a trichofolliculoma at its very late stage

Schulz, Tilman; Hartschuh, Wolfgang

doi:10.1016/s0923-1811(98)83697-9

Cited by 25 publications

(48 citation statements)

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“…Among the cases of FSCH in the literature [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] , only a few cases of giant FSCH have been reported (Table 1) 3-6 . The clinical features of our case were similar to those of the reported giant FSCH cases, except for cerebriform surface and chin involvement.…”

Section: Discussionmentioning

confidence: 99%

A Case of Giant Folliculosebaceous Cystic Hamartoma

Haw

Lee

2009

Ann Dermatol

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Section: Discussionmentioning

confidence: 99%

A Case of Giant Folliculosebaceous Cystic Hamartoma

Haw

Lee

2009

Ann Dermatol

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“…Similar to FSCH, sebaceous trichofolliculoma exhibits a widely dilated cavity or sinus lined by stratified squamous epithelium with numerous sebaceous lobules and rudimentary follicles. 2 Schulz and Hartschuh 4 have suggested that FSCH is a very late-stage trichofolliculoma. They suggested that the late stage of trichofolliculoma exhibits infundibular cyst and sebaceous and follicular differentiation with various signs of catagen and telogen.…”

mentioning

confidence: 99%

Folliculosebaceous Cystic Hamartoma on the Nipple

Lee

You

et al. 2006

The American Journal of Dermatopathology

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Dear Editor, Folliculosebaceous cystic hamartoma (FSCH) is a rare skin lesion comprised of follicular, sebaceous and mesenchymal elements. FSCH mostly involves the head and neck area but some cases involving the upper back, forearm and ear have been reported. However, FSCH located on the nipple is quite rare. Herein, we describe a case of FSCH on the nipple of a 32-year-old woman.A 32-year-old woman visited our clinic to evaluate a single pedunculated soft nodule on the nipple of her right breast. The nodule had been there for 5 years. It was asymptomatic and very slowly growing. The surrounding areola and underlying mammary ducts and breast tissue were unremarkable. There was no history of nipple discharge or bleeding. Her left breast was normal.On physical examination, the lesion was a 0.5 cm · 0.4 cm · 0.3 cm, light brown, soft tumor with a projecting and polypoid configuration, located on the superolateral aspect of the right nipple. There was no evidence of punctum or sinus opening and involvement of ductal orifice was not noticed (Fig. 1). Initial clinical diagnosis was fibroma of the nipple and accessory nipple, and an excisional biopsy was performed.The tumor was totally excised by a 6-mm punch. Histopathological examination revealed mild epidermal proliferation and hyperplasia. Within the dermis, there were multiple hyperplastic sebaceous glands forming nodules around a large, cysticallydilated, follicular infundibular structure lined with stratified squamous epithelium and filled with keratin material. Sebaceous lobules were attached to the cystic structure through sebaceous ducts. The surrounding stroma consisted of concentric, fibrillary bundles of collagen with numerous dilated capillaries and venules. The perifollicular part of the stroma contained large amounts of mucin. There was cleft formation between the perifollicular stroma and the adjacent dermis (Fig. 2). The final diagnosis was folliculosebaceous cystic hamartoma and the lesion has not recurred after total excision.Folliculosebaceous cystic hamartoma was first described in 1991 by Kimura et al.1 and was con-

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“…The histopathologic differential diagnoses include sebaceous hyperplasia, sebaceous trichofolliculoma, fibrofolliculoma, perifolliculoma and dermoid cyst Of these, sebaceous trichofolliculoma (ST) has the most similar features to FSCH and there is a controversy about the relationship between these two conditions 2,3 . ST is a rare variant of trichofolliculoma, usually occurring on the nose as numerous well-differentiated sebaceous lobules and ducts with occasional hair structures arranged around a central cystic "follicle" 12 .…”

Section: Discussionmentioning

confidence: 99%

“…The histogenesis of FSCH is still unclear. Some authors denied that FSCH is a disease entity 2,3 , whereas others regarded it as a distinct adnexal tumor despite the controversial nosology 1,[4][5][6][7][8] . The controversy exists largely in the relationship between FSCH and sebaceous trichofolliculoma.…”

Section: Introductionmentioning

confidence: 99%