Follow-Up and Long-Term Prognosis of Myocarditis and Fulminant Myocarditis

Preliminary discussions about myocardial injury and rehabilitation

“…After mammalian heart injury, the main reaction is myocardial fibrosis and the formation of non-contractile scar tissue, which will damage the heart function and eventually lead to heart failure. Therefore, promoting cardiomyocytes that exit the cell cycle to enter the cell cycle again and replenish the lost cardiomyocytes is the key to achieving myocardial regeneration (8). At the early stage of the embryo, the proliferation level of mouse cardiomyocytes was very high, and the cell proliferation level began to decrease from the 10 to 12th day of the embryo.…”

“…The proportion of left ventricular enlargement and sustained decrease of LVEF in FM patients who survived and were discharged from the hospital was higher than that in NFM patients. A long recovery time of LVEF during hospitalization is an independent risk factor for impaired cardiac function after discharge in FM patients (8).…”

“…It is suggested that bone marrow mesenchymal stem cells (BMSCs) can participate in the reconstruction of damaged myocardium, improve left ventricular ejection fraction, reduce left ventricular end systolic and end diastolic volume, reduce infarct area, and improve left ventricular remodeling (8). However, the long-term survival of BMSCs in infarcted myocardium has not been resolved; the change of microenvironment after myocardial infarction limits the repair ability of stem cells (19).…”