Follow-up investigation into Cryptosporidium prevalence and transmission in Western European dairy farms

Hoque, Sumaiya; Pinto, Pedro; Ribeiro, Cláudia A.; Canniere, Evi; Daandels, Yvonne; Dellevoet, Martine; Bourgeois, Anne; Hammouma, Ourida; Hunter, Paul; Gentekaki, Eleni; Kváč, Martin; Follet, Jérôme; Tsaousis, Anastasios D.

doi:10.1016/j.vetpar.2023.109920

Cited by 6 publications

(2 citation statements)

References 66 publications

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“…In France, variations in the distribution of Cryptosporidium species in different studies are shown in Table 3 . In a previous survey in the Hauts-de-France, it was reported that the most predominant species (42.8%) in adult dairy cattle was C. bovis [ 13 ], while in a follow-up performed in the same area by the same group, C. andersoni was the most prevalent species (57.14%) followed by C. bovis (28.57%) [ 31 ]. Different factors may explain this difference in prevalence and species distribution in the same country such as sampling size, type of breed, farm management practices (intensive, semi-intensive or extensive), farm location (urban/rural) or feeding system among others [ 5 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

Frequency and Molecular Identification of Cryptosporidium in Adult Prim’Holstein Dairy Cattle Farms in the North of France

Certad,

Gantois,

Merlin

et al. 2024

Microorganisms

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Cryptosporidium apicomplexan protozoa are ubiquitous intracellular agents affecting humans and animals. In particular, bovine cryptosporidiosis is recognized as endemic worldwide. However, epidemiological investigations remain limited in France regarding the burden of these parasites in cattle. To improve our understanding of the epidemiology of cryptosporidiosis, the main aim of this study was to determine the frequency and the genetic diversity of Cryptosporidium in adult Prim’Holstein dairy cattle farms in the north of France. Fecal specimens were collected from 1454 non-diarrheic and non-pregnant animals (nulli-, primi-, or multiparous) throughout 20 farms in an area of 110 km around Lille. For Cryptosporidium species identification, nested PCR followed by sequence and phylogenetic analyses were used. The overall frequency of Cryptosporidium spp. in-fection was 30.00% (C.I. 95%: 12.83–54.33) in farms and 0.89% (C.I. 95%: 0.498–1.57) at the individual level. In primi- or multiparous cows, only C. andersoni was found. C. ryanae, C. bovis/xiaoi and C. andersoni were detected in heifers. The phylogenetic tree confirmed that analyzed sequences were grouped with known reference sequences reported in dairy cattle. Further studies on the cumulative prevalence, risks factors and pathogenicity are needed to give a more accurate assessment of the impact of Cryptosporidium infection in dairy cattle in France.

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Section: Discussionmentioning

confidence: 99%

Frequency and Molecular Identification of Cryptosporidium in Adult Prim’Holstein Dairy Cattle Farms in the North of France

Certad,

Gantois,

Merlin

et al. 2024

Microorganisms

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“…Preventive treatment with halofuginone lactate is common practice against cryptosporidiosis, one of the most prevalent causes of neonatal calf diarrhoea worldwide [ 1 ]. Timely administration, before the age of five days, showed to decrease oocyst shedding, severity of diarrhoea and mortality after infection [ 2 – 5 ].…”

Section: Introductionmentioning

confidence: 99%

Abomasitis associated with halofuginone intoxication in pre-weaned calves

van Mol,

Chantillon,

Geerinckx

et al. 2024

BMC Vet Res

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Background In this case series abomasitis as a consequence of halofuginone intoxication is suspected. Case presentation Seven Belgian-Blue calves with complaints of anorexia and weight loss were presented to an university clinic. Ultrasonography showed thickening and edema of the abomasal wall in all cases, suggesting abomasitis. Abomasitis was confirmed on necropsy in three cases. Retrospective analysis clarified the uptake of an overdose of halofuginone lactate (348–421 µg/kg/day). Four animals fully recovered after removal of halofuginone lactate administration, therapy for comorbidities (pneumonia, diarrhoea) and supportive therapy. Conclusion To the authors’ knowledge, this case series is the first report associating halofuginone lactate use with abomasitis. This was suspected after clinical improvement of four of the presented animals after terminating the administration of a high dose of halofuginone lactate, and exclusion of other possible causes. Underlying mechanisms are still unclear.

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