Follow-Up of a Randomized Trial for Oat Cell Carcinoma Evaluating the Efficacy of Peripheral Intravenous Nutrition (PIVN) as Adjunct Treatment

Serrou, B; Cupissol, Didier; Plagne, R; Boutin, Paul; Chollet, Philippe; Carcassonne, Y; Michel, Françoise

doi:10.1007/978-3-642-81685-7_39

Cited by 20 publications

(2 citation statements)

References 12 publications

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“…Several studies have examined the use of NST during chemotherapy to prevent the development of malnutrition or to mitigate its consequences. 64,[70][71][72][73][74][75][76][77][78][79][80][81][82] When used in this fashion, NST does not reduce chemotherapy-related toxicity [70][71][72][73][74][75]77,78,80,81 and does not improve tumor response [70][71][72][73][74][75]77,78,80,81 or patient survival. 70,71,75 All studies were limited by small sample size.…”

Section: Practice Guidelines and Rationalesmentioning

confidence: 99%

A.S.P.E.N. Clinical Guidelines: Nutrition Support Therapy During Adult Anticancer Treatment and in Hematopoietic Cell Transplantation

August

Huhmann

2009

J Parenter Enteral Nutr

442

279

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Section: Practice Guidelines and Rationalesmentioning

confidence: 99%

A.S.P.E.N. Clinical Guidelines: Nutrition Support Therapy During Adult Anticancer Treatment and in Hematopoietic Cell Transplantation

August

Huhmann

2009

J Parenter Enteral Nutr

442

279

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“…The success of PN depends on patient compliance, support by a professional and committed nutritionist and cooperation between the patient, nutritionist, physician and home care provider [67]. In numerous studies, PN failed to reduce the toxicity of chemotherapy [68] and to improve the response rate [69]. Especially for patients with advanced GC and for those who are not malnourished or hypophagic, the risks of PN may outweigh the benefits [70].…”

Section: Nutrition In Patients With Advanced Gcmentioning

confidence: 99%

Nutrition in Patients with Gastric Cancer: An Update

Rosania¹,

Chiapponi

Malfertheiner³

et al. 2015

Gastrointest Tumors

113

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Background: Nutritional management of patients with gastric cancer (GC) represents a challenge. Summary: This review provides an overview of the present evidence on nutritional support in patients with GC undergoing surgery as well as in those with advanced disease. Key Message: For patients undergoing surgery, the preoperative nutritional condition directly affects postoperative prognosis, overall survival and disease-specific survival. Perioperative nutritional support enriched with immune-stimulating nutrients reduces overall complications and hospital stay but not mortality after major elective gastrointestinal surgery. Early enteral nutrition after surgery improves early and long-term postoperative nutritional status and reduces the length of hospitalization as well. Vitamin B₁₂ and iron deficiency are common metabolic sequelae after gastrectomy and warrant appropriate replacement. In malnourished patients with advanced GC, short-term home complementary parenteral nutrition improves the quality of life, nutritional status and functional status. Total home parenteral nutrition represents the only modality of caloric intake for patients with advanced GC who are unable to take oral or enteral nutrition. Practical Implications: Early evaluations of nutritional status and nutritional support represent key aspects in the management of GC patients with both operable and advanced disease.

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Critical evaluation of the role of nutritional support with chemotherapy

Chlebowski¹

1985

Cancer

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Although weight loss has an adverse impact on cancer patient survival, the ability of caloric provision via total parenteral nutrition (TPN) to favorably influence outcome in chemotherapy‐treated populations is not established. In randomized trials, no significant improvement in either response or survival was associated with TPN addition to chemotherapeutic treatment of adult patients with lymphoma, sarcoma, colon cancer, adenocarcinoma and small cell carcinoma of the lung, or testicular carcinoma. In two instances, TPN addition was associated with decreased survival, again raising the concern that caloric support in the absence of effective antitumor therapy might stimulate cancer growth. In any event, the hypothesis that nutritional repletion of a malnourished cancer patient receiving chemotherapy will improve clinical outcome remains to be critically tested, as studies demonstrating sequential improvement in lean body mass have not been reported. Most recently, consideration of potential mechanisms underlying the development of cancer cachexia has led to new strategies for nutritional intervention. For example, hypogonadism or low testosterone levels have been described in male patient populations with advanced cancer and correlated with weight loss and adverse outcome, leading to trial of replacement therapy with nandrolone decanoate. Similarly, the frequent identification of abnormal glucose metabolism in the patients with cancer cachexia has stimulated clinical trials with agents such as hydrazine sulfate and insulin designed to reverse the metabolic abnormality. Whether such efforts designed to alter metabolic abnormalities associated with cancer cachexia will improve clinical outcome will be determined in ongoing clinical trials.

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Follow-Up of a Randomized Trial for Oat Cell Carcinoma Evaluating the Efficacy of Peripheral Intravenous Nutrition (PIVN) as Adjunct Treatment

Cited by 20 publications

References 12 publications

A.S.P.E.N. Clinical Guidelines: Nutrition Support Therapy During Adult Anticancer Treatment and in Hematopoietic Cell Transplantation

A.S.P.E.N. Clinical Guidelines: Nutrition Support Therapy During Adult Anticancer Treatment and in Hematopoietic Cell Transplantation

Nutrition in Patients with Gastric Cancer: An Update

Critical evaluation of the role of nutritional support with chemotherapy

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