Follow-up of children born with an umbilical arterial blood pH &lt;7

Nagel, H; Vandenbussche, Frank P.H.A.; Oepkes, Dick; Jennekens‐Schinkel, A.; Laan, L.A.E.M.; Gravenhorst, J. Bennebroek

doi:10.1016/0002-9378(95)90423-9

Cited by 64 publications

(45 citation statements)

References 18 publications

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“…7.00) than in non-acidemic control infants. This is in accordance with the fi ndings of others [4,7,41] . In addition, the incidence of seizures was related to the severity of acidemia in both preterm and full-term neonates.…”

Section: Full-term Neonatessupporting

confidence: 94%

“…The chances of developing encephalopathy and an adverse neurodevelopmental outcome are higher with more severe degrees of acidemia, especially with cord blood pH values ! 7.00 [3][4][5][6][7][8] . Compared with full-term infants, there is remaining controversy relating to the effects of a low pH of the umbilical artery (UApH) on outcome in (extremely) preterm infants.…”

Section: Introductionmentioning

confidence: 99%

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Severe Umbilical Cord Acidemia and Neurological Outcome in Preterm and Full-Term Neonates

et al. 2005

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Background: Severe intrauterine hypoxia-ischemia and acidemia may lead to a disturbed neurodevelopment. Objectives: To study the effects of acidemia at birth on neurodevelopment in preterm and full-term neonates. Subjects and Methods: Short- and long-term outcome were studied retrospectively in 44 inborn preterms and 95 full-terms with severe acidemia at birth defined as a pH of the umbilical artery <7.00. Outcome was compared with 67 preterm and 90 full-term non-acidemic neonates (pH > 7.15). Intraventricular hemorrhage (preterms) or seizures (both preterms and full-terms) were considered an adverse short-term outcome. Neonatal death, cerebral palsy or neurodevelopmental delay were considered an adverse long-term outcome. Results: Severe intraventricular hemorrhage (IVH) occurred in 5 of the 44 (11%) acidemic preterms and in none of the 67 (0%) non-acidemic preterms (p < 0.01). Seizures were observed in 9 of the 44 (20%) and 11 of the 95 (12%) acidemic preterms and full-terms, respectively, and in none of the 67 (0%) and 1 of the 90 (1%) non-acidemic preterms and full-terms, respectively (p < 0.001 for preterms, p < 0.01 for full-terms). Nine preterms (6 acidemic, 3 non-acidemic) and 2 full-terms (both acidemic) died in the neonatal period. Adverse long-term outcome occurred in 32% of the acidemic preterms, in 21% of the non-acidemic preterms, in 7% of the acidemic full-terms and in 7% of the non-acidemic full-terms. Conclusions: Acidemia at birth increased the occurrence of severe IVH in preterm neonates and seizures in both preterm and full-term neonates. However, no significant effect of acidemia on long-term outcome could be demonstrated.

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Section: Full-term Neonatessupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Severe Umbilical Cord Acidemia and Neurological Outcome in Preterm and Full-Term Neonates

et al. 2005

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“…A pH value that falls between 7.0 and 7.1 (i.e., two standard deviations below the mean arterial pH at birth) has often been cited as a cutoff for severe and profound birth asphyxia (for a review, see Nagel et al, 1995). The findings from the current study suggest that a relatively small risk for birth-related hypoxia, defined as a pH value falling above the established critical level, is by no means too negligible to exert an appreciable influence on intellectual outcome.…”

Section: Discussionmentioning

confidence: 99%

Influence of slight to moderate risk for birth hypoxia on acquisition of cognitive and language function in the preterm infant: A cross-sectional comparison with preterm-birth controls.

2003

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The cognitive and language performance of a group of 26 preterm-birth preschool and early school-age children with slight to moderate risk for perinatal hypoxia was compared with the performance of a preterm-birth comparison group of 26 children. Despite the relatively small discrepancy in degree of risk, the cognitive performance of the 2 groups diverged significantly. When data for children with known perinatal arterial pH were combined, a curvilinear (quadratic) regression model provided the best fit. Increasing acidosis was linearly related to decreases in cognitive skills, with the bend in the curve occurring well within the normal range of pH values. Hence, in the preterm infant, even minor risk for birth hypoxia may result in discernible deviation from the expected developmental trajectory.Perinatal hypoxic-ischemic insult is thought to contribute not only to mortality and morbidity in the neonate (Gunn,

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“…Incidence of intubation and mechanical ventilation in our study was 26% which is similar to the study done by Naegel, Goldaber et al, where as in Perlman and Risser it was found to be high. 12,14 Our results also showed significant increase in risk of intubation and need for mechanical ventilation among cases with decrease in umbilical arterial pH (p=0.001) as suggested by Goldaber et al, and Andres et al 3,14 Decrease in umbilical arterial pH was significantly associated with low Apgar score in our study (p=0.002) which was consistent with result of other studies done by Goldaber et al and Vandenberg et al 14,15 The incidence of thrombocytopenia found in case group was 58%. The reported incidence in our study was similar to study done by Oren et al, Gunn et al, Gluck man et al [16][17][18] In our study, out of 11 babies with significant acidosis 1 baby (9%) died.…”

Section: Discussionmentioning

confidence: 99%

The strength of correlation between umbilical cord pH and early neonatal outcome

Prasanna

Karthikeyan

Mani

et al. 2016

Int J Contemp Pediatr

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Follow-up of children born with an umbilical arterial blood pH <7

Cited by 64 publications

References 18 publications

Severe Umbilical Cord Acidemia and Neurological Outcome in Preterm and Full-Term Neonates

Severe Umbilical Cord Acidemia and Neurological Outcome in Preterm and Full-Term Neonates

Influence of slight to moderate risk for birth hypoxia on acquisition of cognitive and language function in the preterm infant: A cross-sectional comparison with preterm-birth controls.

The strength of correlation between umbilical cord pH and early neonatal outcome

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