Follow-up of colorectal cancer

Rosen, Michael M.; Chan, Linda S.; Beart, Robert W.; Vukasin, Petar; Anthone, Gary J.

doi:10.1007/bf02239433

Cited by 191 publications

(108 citation statements)

References 20 publications

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“…Although curative resection of advanced colorectal carcinoma without synchronous distant metastasis (ie stage II or III) is feasible, a significant number of patients develop local recurrence or distant metastasis heterochronously (Newland et al, 1995;Rosen et al, 1998). Liver metastasis is an important prognostic determinant for the clinical prognosis of colorectal carcinoma (Doci et al, 1991;Wanebo et al, 1996;Rees et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

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Prognostic significance of dysadherin expression in advanced colorectal carcinoma

Aoki

Shimamura²,

Shibata³

et al. 2003

Br J Cancer

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A novel glycoprotein, dysadherin, has an anti-cell -cell adhesion function through downregulating E-cadherin. In this study, we investigated the expressions of dysadherin and E-cadherin in 82 patients with stage II and III colorectal carcinomas to determine the correlation between the two molecules and the clinicopathologic features of each tumour. Dysadherin was not expressed in normal colorectal epithelium. Fifty-one per cent of tumours showed dysadherin immunopositivity in over 50% of cancer cells. Thirty-eight per cent of tumours showed reduced E-cadherin immunopositivity. The increased expression of dysadherin was significantly associated with lung metastasis (P ¼ 0.003). The increased expression of dysadherin had a significant impact on patient survival (P ¼ 0.0099 and 0.0036, log-rank test for overall and recurrence-free survival rate, respectively). Furthermore, tumour with increased expression of dysadherin and reduced expression of E-cadherin showed the worst prognosis (P ¼ 0.0043 and 0.0028, log-rank test for overall and recurrence-free survival rate, respectively). These results suggest that increased dysadherin expression is a significant indicator of poor prognosis for patients with advanced colorectal carcinoma.

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Section: Discussionmentioning

confidence: 99%

“…A significant number of patients with colorectal carcinoma who undergo apparently curative resection develop local recurrence or distant metastasis (Rosen et al, 1998). Adjuvant chemotherapy or radiation therapy is needed after resection for such biologically aggressive colorectal carcinomas.…”

mentioning

confidence: 99%

Prognostic significance of dysadherin expression in advanced colorectal carcinoma

Aoki

Shimamura²,

Shibata³

et al. 2003

Br J Cancer

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“…The meta-analysis by Rosen et al (97) included the two first published randomized follow-up studies (7,18) and three comparative cohort studies (11,17,95), totalling 2,005 patients. Only studies including CEA in the follow-up schedule were included, and for that reason the study by Kjeldsen et al (16) was excluded.…”

Section: Meta-analysesmentioning

confidence: 99%

Follow-up after Colorectal Cancer Surgery

Ohlsson

Pålsson

2003

Acta Oncologica

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“…A significant number of patients with colorectal carcinoma who undergo apparently curative operation unfortunately develop local recurrence or distant metastasis leading to shorter survival (Rosen et al, 1998). Therefore, adjuvant therapy is needed after surgical resection for such biologically aggressive colorectal carcinomas.…”

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confidence: 99%

Slug expression is an independent prognostic parameter for poor survival in colorectal carcinoma patients

et al. 2006

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Slug, a member of the Snail family of transcription factors, plays a crucial role in the regulation of epithelial-mesenchymal transition (EMT) by suppressing several epithelial markers and adhesion molecules including E-cadherin. Recently, several studies have reported Slug to be expressed in breast carcinoma, oesophageal carcinoma accompanied with shorter survival. In this study, we first investigated expression of Slug mRNA in five colorectal carcinoma cell lines by reverse transcription -polymerase chain reaction. Furthermore, we investigated Slug and E-cadherin expression by immunohistochemistry in 138 patients with colorectal carcinoma. Slug mRNA was clearly expressed in four out of five colorectal carcinoma cell lines. Positive expression of Slug and E-cadherin was observed in 37 and 58% of cases, respectively. The positive expression of Slug was significantly associated with Dukes stage and distant metastasis (P ¼ 0.0027 and 0.0007), and the positive expression of Slug had a significant impact on patient overall survival (Po0.0001, log-rank test). Moreover, patients with positive expression of Slug and reduced expression of E-cadherin showed the worst prognosis (Po0.0001, log-rank test). Multivariate analysis indicated that Slug expression was an independent prognostic factor. These results suggest that positive Slug expression in colorectal carcinoma patients may become a significant parameter of poor prognosis.

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Follow-up of colorectal cancer

Abstract: Our study concludes that intensive follow-up detects more recurrent cancers at a stage amenable to curative resection, resulting in an improvement in survival of recurrences and an increased overall five-year cumulative rate of survival.

Cited by 191 publications

References 20 publications

Prognostic significance of dysadherin expression in advanced colorectal carcinoma

Prognostic significance of dysadherin expression in advanced colorectal carcinoma

Follow-up after Colorectal Cancer Surgery

Slug expression is an independent prognostic parameter for poor survival in colorectal carcinoma patients

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