2024
DOI: 10.1038/s41598-024-53776-9
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Follow-up of intramyocardial bone marrow mononuclear cell transplantation beyond 10 years

Severi Mulari,
Risto Kesävuori,
Juhani A. Stewart
et al.

Abstract: Bone marrow mononuclear cells (BMMCs) have been evaluated for their ability to improve cardiac repair and benefit patients with severe ischemic heart disease and heart failure. In our single-center trial in 2006–2011 we demonstrated the safety and efficacy of BMMCs injected intramyocardially in conjunction with coronary artery bypass surgery. The effect persisted in the follow-up study 5 years later. In this study, we investigated the efficacy of BMMC therapy beyond 10 years. A total of 18 patients (46%) died … Show more

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