Follow up of patients who start treatment with antidepressants: treatment satisfaction, treatment compliance, efficacy and safety

López-Torres, Jesús; Párraga, Ignacio; Campo, José M. del Campo-del; Villena, Alejandro

doi:10.1186/1471-244x-13-65

Cited by 14 publications

(11 citation statements)

References 37 publications

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“…The risk–benefit ratio of antidepressants has been proven in clinical trials for several medical conditions (major depressive disorders, neuropathic pain, generalized anxiety, panic attack, obsessive–compulsive disorder, post‐traumatic stress disorder, and migraine) . However, nonadherence to antidepressant treatment is a major obstacle to its effectiveness in clinical practice . This nonadherence also leads to relapse, recurrence, and evolution to chronic depression .…”

Section: Introductionmentioning

confidence: 99%

Antidepressant adherence patterns in older patients: use of a clustering method on a prescription database

Braunstein

Hardy

Boucherie

et al. 2017

Fundam Clin Pharmacol

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According to the World Health Organization, depression will become the second most important cause of disability worldwide by 2020. Our objective was to identify patterns of adherence to antidepressant treatments in older patients using several indicators of adherence and to characterize these patterns in terms of medication exposure. We conducted a retrospective cohort study using the French National Health Insurance reimbursement database. Incident antidepressant users aged more than 65 were included from July 1, 2010, to June 30, 2011, and followed up for 18 months. Antidepressant and other psychotropic drugs (opioids, benzodiazepines, antipsychotics, anti-epileptics) were recorded. Adherence to antidepressant treatment was assessed by several measures including proportion of days covered, discontinuation periods, persistence of treatment, and doses dispensed. Patients were classified according to their adherence patterns using a mixed clustering method. We identified five groups according to antidepressant adherence. One group (n = 7505, 26.9%) was fully adherent with regard to guidelines on antidepressant use. Two patterns of nonadherent users were identified: irregular but persistent users (n = 5131, 18.4%) and regular but nonpersistent users (n = 9037, 32.4%). Serotonin reuptake inhibitors were the most frequently dispensed antidepressant class (70.6%), followed by other antidepressants (43.3%, mainly serotonin-norepinephrine reuptake inhibitors and tianeptine) and tricyclic antidepressants (TCAs) (13.4%). Nonadherent users more frequently had a dispensing of TCA, opioid, and anti-epileptic medication than adherent users. Health policies to improve adherence to antidepressant treatment may require better training of physicians and pharmacists, insisting on the important role of the continuation period of antidepressant treatment.

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Section: Introductionmentioning

confidence: 99%

Antidepressant adherence patterns in older patients: use of a clustering method on a prescription database

Braunstein

Hardy

Boucherie

et al. 2017

Fundam Clin Pharmacol

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“…patients may receive antidepressants unnecessarily, while those on prescriptions may not be optimally followed [21][22][23]. Regular follow-up of psychological status, adherence to treatment, potential drug-drug interactions or side effects is clearly important [24][25][26][27]. One of the reasons for unwarranted prescription or lack of follow-up may be that many different medical specialities are involved in a cancer patients' treatment.…”

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confidence: 99%

A systematic review and meta‐analysis of prescribing practices of antidepressants in cancer patients

et al. 2016

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Background: Antidepressants are commonly used for the pharmacological treatment of depression. We aimed to summarise the prevalence of antidepressant prescription to cancer patients, and differences by study or patient characteristics.Methods: PubMed, Embase, Web of Science, Scopus and psychINFO were searched using keywords 'psychotropic', 'antidepressants', 'prescription' and 'cancer'. Prevalence of antidepressants, type, dose and follow-up of antidepressants and prescriber details were extracted.Results: Overall, 1537 articles between 1979 and February 2015 were found, 38 met the inclusion criteria and were reviewed according to PRISMA guidelines. The prevalence rate of prescribing antidepressants to cancer patients was 15.6% (95% CI = 13.3-18.3). Prescription was significantly less common in studies from Asia (7.4%; 95% CI = 4.3-12.5), more common in female (22.6%; 95% CI = 16.0-31.0) or breast cancer patients (22.6%; 95% CI = 16.0-30.9). Selective serotonin reuptake inhibitors were the most frequently prescribed antidepressants. General practitioners and psychiatrists, followed by oncologists, were identified as the major providers of antidepressant prescriptions to cancer patients. Few studies reported the exact dose, length of time drugs were prescribed for or follow-up regimens.Conclusions: There is considerable variation in the prescribing patterns of antidepressants across the world, with few studies reporting robust data on exact dose or follow-up regimens. Prospective studies that monitor antidepressant prescribing, including details of reasons for prescribing and the healthcare providers involved, dose, change in dose or type of medication and follow-up are needed to ascertain whether patients are being treated optimally and if side effects or drug-drug interactions are identified and managed.

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“…Consequently, it is not surprising that the adherence of patients to SSRIs is poor, with a recent study reporting 40%-50% failure during the maintenance period of treatment. 77 Recently, a novel dual melatonergic and specif ic serotonergic antidepressant, agomelatine (Valdoxan), has shown potential in SAD patients. 78 This compound aims to address both the abnormalities in the DLMO and the decrease in serotonin levels found in SAD.…”

Section: Pharmacological Chronobiotic Interventionsmentioning

confidence: 99%

An insight into light as a chronobiological therapy in affective disorders

Walsh¹,

Atkinson²,

Corlett³

et al. 2014

CPT

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Abstract:The field of chronobiology has vastly expanded over the past few decades, bringing together research from the fields of circadian rhythms and sleep. The importance of the environmental day-night cycle on our health is becoming increasingly evident as we evolve into a 24-hour society. Reducing or changing sleep times against our natural instincts to rest at night has a detrimental impact on our well-being. The mammalian circadian clock, termed "the suprachiasmatic nucleus", is responsible for synchronizing our behavioral and physiological outputs to the environment. It utilizes light transcoded by specialized retinal photoreceptors as its cue to set internal rhythms to be in phase with the light-dark cycle. Misalignment of these outputs results in symptoms such as altered/disturbed sleep patterns, changes in mood, and physical and mental exhaustion -symptoms shared by many affective clinical disorders. Key links to circadian abnormalities have been found in a number of disorders, such as seasonal affective disorder, nonseasonal depression, and bipolar affective disorder. Furthermore, therapies developed through chronobiological research have been shown to be beneficial in the treatment of these conditions. In this article, we discuss the impact of circadian research on the management of affective disorders, giving evidence of how a misaligned circadian system may be a contributor to the symptoms of depression and how moderating circadian rhythms with light therapy benefits patients.

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Follow up of patients who start treatment with antidepressants: treatment satisfaction, treatment compliance, efficacy and safety

Cited by 14 publications

References 37 publications

Antidepressant adherence patterns in older patients: use of a clustering method on a prescription database

Antidepressant adherence patterns in older patients: use of a clustering method on a prescription database

A systematic review and meta‐analysis of prescribing practices of antidepressants in cancer patients

An insight into light as a chronobiological therapy in affective disorders

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