Follow-up of preterm children: important to document dropouts

Wolke, Dieter; Söhne, Brigitte; Ohrt, Barbara; Riegel, K

doi:10.1016/s0140-6736(95)90425-5

Cited by 160 publications

(112 citation statements)

References 4 publications

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“…It is possible that parents who have not come to terms with their highly stressful medical history may tend to avoid situations where these difficulties are highlighted. 28 Although no differences in perinatal characteristics and socio-economic status were found between the included and lost-to-follow-up group, losses in follow-up studies are mostly unrelated to prenatal, perinatal or neonatal medical conditions. 29 However, parents with low educational levels and those with children with severe developmental delay are most likely to drop out of follow-up programmes.…”

Section: Strengths and Limitationsmentioning

confidence: 86%

Long‐term neurodevelopmental outcome after selective feticide in monochorionic pregnancies

Klink

Koopman

Middeldorp

et al. 2015

BJOG

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ObjectiveTo assess the incidence of and risk factors for adverse long‐term neurodevelopmental outcome in complicated monochorionic pregnancies treated with selective feticide at our centre between 2000 and 2011.DesignObservational cohort study.SettingNational referral centre for fetal therapy (Leiden University Medical Centre, the Netherlands).PopulationNeurodevelopmental outcome was assessed in 74 long‐term survivors.MethodsChildren, at least 2 years of age, underwent an assessment of neurologic, motor and cognitive development using standardised psychometric tests and the parents completed a behavioural questionnaire.Main outcome measuresA composite outcome termed neurodevelopmental impairment including cerebral palsy (GMFCS II‐V), cognitive and/or motor test score of <70, bilateral blindness or bilateral deafness requiring amplification.ResultsA total of 131 monochorionic pregnancies were treated with selective feticide at the Leiden University Medical Centre. Overall survival rate was 88/131 (67%). Long‐term outcome was assessed in 74/88 (84%). Neurodevelopmental impairment was detected in 5/74 [6.8%, 95% confidence interval (CI), 1.1–12.5] of survivors. Overall adverse outcome, including perinatal mortality or neurodevelopmental impairment was 48/131 (36.6%). In multivariate analysis, parental educational level was associated with cognitive test scores (regression coefficient B 3.9, 95% CI 1.8–6.0). Behavioural problems were reported in 10/69 (14.5%).ConclusionsAdverse long‐term outcome in survivor twins of complicated monochorionic pregnancies treated with selective feticide appears to be more prevalent than in the general population. Cognitive test scores were associated with parental educational level.Tweetable abstractNeurodevelopmental impairment after selective feticide was detected in 5/74 (6.8%, 95% CI 1.1–12.5) of survivors.

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Section: Strengths and Limitationsmentioning

confidence: 86%

Long‐term neurodevelopmental outcome after selective feticide in monochorionic pregnancies

Klink

Koopman

Middeldorp

et al. 2015

BJOG

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“…Those who participated across all time points were socially advantaged and had less risk of psychopathology (i.e., reduced prevalence), a pattern of selective dropout found in most longitudinal investigations (Hille et al 2005;Wolke et al 1995). This may work against stated hypotheses due to reduced statistical power, in particular, where disorders are infrequent such as depression in early adolescence.…”

Section: Discussionmentioning

confidence: 99%

Peer Victimization in Childhood and Internalizing Problems in Adolescence: A Prospective Longitudinal Study

Zwierzynska

Wolke

Lereya

2012

J Abnorm Child Psychol

Self Cite

236

169

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Traumatic childhood experiences have been found to predict later internalizing problems. This prospective longitudinal study investigated whether repeated and intentional harm doing by peers (peer victimization) in childhood predicts internalizing symptoms in early adolescence. 3692 children from the Avon Longitudinal Study of Parents and Children (ALSPAC), as well as their mothers and teachers, reported on bullying in childhood (7-10 years) and internalizing problems in early adolescence (11-14 years). Controlling for prior psychopathology, family adversity, gender and IQ, being a victim of bullying was associated with higher overall scores, as well as increased odds of scoring in the severe range (>90 th percentile) for emotional and depression symptoms. Victims were also more likely to show persistent depression symptoms over a 2-year period. These associations were found independent of whether mothers, teachers or the children reported on bullying. It is concluded that peer victimization in childhood is a precursor of both short-lived and persistent internalizing symptoms, underlining the importance of environmental factors such as peer relationships in the etiology of internalizing problems.

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“…The main limitations of this study relate to its retrospective design and to the lack of complete datasets at the 2-year follow-up examination for some infants. This loss to follow-up bias is a major drawback of all long-term follow-up studies and results in unclear consequences for the remaining study population [17,18,19]. In addition, there is increasing evidence that 2-year outcome assessments in very preterm infants might be limited in predicting later cognitive functions [20].…”

Section: Discussionmentioning

confidence: 99%

Randomized Controlled Trials in Very Preterm Infants: Does Inclusion in the Study Result in Any Long-Term Benefit?

et al. 2014

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Background: Since the introduction of randomized controlled trials (RCT) in clinical research, there has been discussion of whether enrolled patients have worse or better outcomes than comparable non-participants. Objective: To investigate whether very preterm infants randomized to a placebo group in an RCT have equivalent neurodevelopmental outcomes to infants who were eligible but not randomized (eligible NR). Methods: In the course of an RCT investigating the neuroprotective effect of early high-dose erythropoietin on the neurodevelopment of very preterm infants, the outcome data of 72 infants randomized to placebo were retrospectively compared with those of 108 eligible NR infants. Our primary outcome measures were the mental (MDI) and psychomotor (PDI) developmental indices of the Bayley Scales of Infant Development II at 24 months of corrected age. The outcomes of the two groups were considered equivalent if the confidence intervals (CIs) of their mean differences fitted within our ±5-point margin of equivalence. Results: Except for a higher socioeconomic status of the trial participants, both groups were balanced for most perinatal variables. The mean difference (90% CI) between the eligible NR and the placebo group was -2.1 (-6.1 and 1.9) points for the MDI and -0.8 (-4.2 and 2.5) points for the PDI. After adjusting for the socioeconomic status, maternal age and child age at follow-up, the mean difference for the MDI was -0.5 (-4.3 and 3.4) points. Conclusions: Our results indicate that the participation of very preterm infants in an RCT is associated with equivalent long-term outcomes compared to non-participating infants.

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Follow-up of preterm children: important to document dropouts

Cited by 160 publications

References 4 publications

Long‐term neurodevelopmental outcome after selective feticide in monochorionic pregnancies

Long‐term neurodevelopmental outcome after selective feticide in monochorionic pregnancies

Peer Victimization in Childhood and Internalizing Problems in Adolescence: A Prospective Longitudinal Study

Randomized Controlled Trials in Very Preterm Infants: Does Inclusion in the Study Result in Any Long-Term Benefit?

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