Following the goose liver development by means of cross-sectional digital imaging, liver histology and blood biochemical parameters

Locsmándi, L.; Hegedűs, Géza; Andrássy-Baka, G.; Bogenfürst, Ferenc; Romvári, Róbert

doi:10.1556/abiol.58.2007.1.4

Cited by 18 publications

(18 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The standard deviation of all investigated clinicochemical parameters increased till the end of the experiment, showing the highly different physiological response of the animals on the force-feeding process. These results are in harmony with previous findings [3].…”

Section: Results Of Chemical Analysissupporting

confidence: 92%

“…The fatty goose liver production of Hungary is nearly 2000 t per annum, being a world leader, and the country has old traditions of fattening [2]. During gavage the birds are strongly overfed with high-fat diets that provides, besides 8-10-fold liver mass increase, severe dyslipidemia [3]. Because of the force-feeding procedure, gavage-based foie gras production is controversial and production or retailed products are denied in several countries, and there is an expressed need for avoiding gavage in foie gras production.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Multicomponent blood lipid analysis by means of near infrared spectroscopy, in geese

Bázár

Éles

Kovács

et al. 2016

Talanta

View full text Add to dashboard Cite

a b s t r a c tThis study provides accurate near infrared (NIR) spectroscopic models on some laboratory determined clinicochemical parameters (i.e. total lipid (5.57 71.95 g/l), triglyceride (2.59 71.36 mmol/l), total cholesterol (3.81 7 0.68 mmol/l), high density lipoprotein (HDL) cholesterol (2.45 70.58 mmol/l)) of blood serum samples of fattened geese. To increase the performance of multivariate chemometrics, samples significantly deviating from the regression models implying laboratory error were excluded from the final calibration datasets. Reference data of excluded samples having outlier spectra in principal component analysis were not marked as false. Samples deviating from the regression models but having non outlier spectra in PCA were identified as having false reference constituent values. Based on the NIR selection methods, 5% of the reference measurement data were rated as doubtful. The achieved models reached R 2 of 0.864, 0.966, 0.850, 0.793, and RMSE of 0.639 g/l, 0.232 mmol/l, 0.210 mmol/l, 0.241 mmol/l for total lipid, triglyceride, total cholesterol and HDL cholesterol, respectively, during independent validation. Classical analytical techniques focus on single constituents and often require chemicals, timeconsuming measurements, and experienced technicians. NIR technique provides a quick, cost effective, non-hazardous alternative method for analysis of several constituents based on one single spectrum of each sample, and it also offers the possibility for looking at the laboratory reference data critically. Evaluation of reference data to identify and exclude falsely analyzed samples can provide warning feedback to the reference laboratory, especially in the case of analyses where laboratory methods are not perfectly suited to the subjected material and there is an increased chance of laboratory error.

show abstract

Section: Results Of Chemical Analysissupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Multicomponent blood lipid analysis by means of near infrared spectroscopy, in geese

Bázár

Éles

Kovács

et al. 2016

Talanta

View full text Add to dashboard Cite

show abstract

“…The data from our study correspond to the changes in the goose liver's histostructure found via computer tomography and histological examination, after 18 days of force-feeding (Locsmandi et al, 2007).…”

Section: Discussionsupporting

confidence: 86%

Histostructure of different quality classes of fattened liver from mule ducks

Petrov¹,

Bochukov²,

Penchev³

et al. 2017

BJVM

View full text Add to dashboard Cite

SummaryPetrov, P., A. Bochukov, G. Penchev & V. Gerzilov, 2017. Histostructure of different quality classes of fattened liver from mule ducks. Bulg. J. Vet. Med., 20, No 4,[319][320][321][322][323][324][325][326] This study encompassed a total of 15040 fattened liver samples, obtained during the four seasons of the year. The fattened liver quality was evaluated with regard to its weight and structure and classified in five classes. The analysis of the results indicated that the largest amount of fattened liver from the two highest quality classes -"Esc" and "E" was obtained during the autumn (85.46 % total), whereas in the other seasons the largest amounts of fattened liver were of the "AD" class. The spring was a period when an increase in the relative share of low-quality liver of grade "TV" (20.87 %) and "C" (5.07 %) was detected. The histological studies indicated that hepatocytes with large-drop fatty infiltration were predominant in liver of classes "Esc" and "E", with preserved cellular boundaries, with the exception of sporadic cases in the "Esc" class, mostly in the autumn. A specific feature for the "AD" quality class was the prevalence of glandular tubules, with predominantly small-and mediumdrop fatty infiltration occurring within their hepatocytes. Seasonal differences in the histostructure of the fattened liver were also detected. In the "TV" quality class two types of glandular tubules with small-and medium-drop fatty infiltration were observed. In some cases, large-drop fatty infiltration could be observed as well -mostly in the summer, and connective tissue between the glandular tubules was preserved, without fattening of its cells. In the "C" quality class, fatty infiltration was incomplete. The histological image showed mostly small-drop fatty infiltration in the cytoplasm of most hepatocytes.

show abstract

“…In overfed geese, liver weight can increase from approximately 100 g to approximately 800 g in 2 weeks due to a large amount of lipid accumulation8. The capacity for and the tolerance to severe hepatic steatosis without overt liver injuries9 suggests the existence of prosteatotic and protective components in goose. Using goose as a unique model for fatty liver study, these components may be identified and thus provide novel therapeutic targets to combat human NAFLD.…”

mentioning

confidence: 99%

Prosteatotic and Protective Components in a Unique Model of Fatty Liver: Gut Microbiota and Suppressed Complement System

Liu

Zhao

Wang

et al. 2016

Sci Rep

View full text Add to dashboard Cite

Goose can develop severe hepatic steatosis without overt injury, thus it may serve as a unique model for uncovering how steatosis-related injury is prevented. To identify the markedly prosteatotic and protective mechanisms, we performed an integrated analysis of liver transcriptomes and gut microbial metagenomes using samples collected from overfed and normally-fed geese at different time points. The results indicated that the fatty liver transcriptome, initially featuring a ‘metabolism’ pathway, was later joined by ‘cell growth and death’ and ‘immune diseases’ pathways. Gut microbiota played a synergistic role in the liver response as microbial and hepatic genes affected by overfeeding shared multiple pathways. Remarkably, the complement system, an inflammatory component, was comprehensively suppressed in fatty liver, which was partially due to increased blood lactic acid from enriched Lactobacillus. Data from in vitro studies suggested that lactic acid suppressed TNFα via the HNF1α/C5 pathway. In conclusion, gut microbes and their hosts respond to excess energy influx as an organic whole, severe steatosis and related tolerance of goose liver may be partially attributable to gut microbiotic products and suppressed complement system, and lactic acid from gut microbiota participates in the suppression of hepatic TNFα/inflammation through the HNF1α/C5 pathway.

show abstract

Following the goose liver development by means of cross-sectional digital imaging, liver histology and blood biochemical parameters

Cited by 18 publications

References 12 publications

Multicomponent blood lipid analysis by means of near infrared spectroscopy, in geese

Multicomponent blood lipid analysis by means of near infrared spectroscopy, in geese

Histostructure of different quality classes of fattened liver from mule ducks

Prosteatotic and Protective Components in a Unique Model of Fatty Liver: Gut Microbiota and Suppressed Complement System

Contact Info

Product

Resources

About