Fondaparinux and Lepirudin as Therapeutic Alternatives in a Disseminated Eczematous Skin Reaction to Low-Molecular-Weight Heparin

Sánchez-Mateos, D.I. Santiago; Eguren, C.; Argila, D. de; Sánchez‐Pérez, Javier

doi:10.1016/s1578-2190(10)70845-3

Cited by 2 publications

(4 citation statements)

References 8 publications

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“…Based on the current literature, fondaparinux has been a useful alternative in at least 40 cases of non‐immediate cutaneous reactions from heparins and heparinoids . Various studies and case reports from centres in Germany, Austria and Spain demonstrated that cross‐reactivity is not uncommon between various types of UFH and LMWH and between heparins and heparinoids.…”

Section: Discussionmentioning

confidence: 99%

“…Various studies and case reports from centres in Germany, Austria and Spain demonstrated that cross‐reactivity is not uncommon between various types of UFH and LMWH and between heparins and heparinoids. In a total of 48 cases where patients with confirmed non‐immediate reactions to heparins or heparinoids were challenged with fondaparinux, 43 did not demonstrate any non‐immediate cutaneous reaction to fondaparinux . There are only five cases of cross‐reactivity to fondaparinux reported, with three of these reactions occurring only after rechallenge .…”

Section: Discussionmentioning

confidence: 99%

“…Based on the current literature, fondaparinux has been a useful alternative in at least 40 cases of non-immediate cutaneous reactions from heparins and heparinoids. 3,[5][6][7][8][9][10][11] Various studies and case reports from centres in Germany, Austria and Spain demonstrated that cross-reactivity is not uncommon between various types of UFH and LMWH and between heparins and heparinoids. In a total of 48 cases where patients with confirmed non-immediate reactions to heparins or heparinoids were challenged with fondaparinux, 43 did not demonstrate any non-immediate cutaneous reaction to fondaparinux.…”

Section: Discussionmentioning

confidence: 99%

“…In a total of 48 cases where patients with confirmed non-immediate reactions to heparins or heparinoids were challenged with fondaparinux, 43 did not demonstrate any non-immediate cutaneous reaction to fondaparinux. 3,[6][7][8][9][10][11][12][13] There are only five cases of cross-reactivity to fondaparinux reported, with three of these reactions occurring only after rechallenge. 7,[11][12][13] All five reactions were localised cutaneous reactions with no reports of anaphylaxis.…”

Section: Discussionmentioning

confidence: 99%

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Non‐immediate heparin and heparinoid cutaneous allergic reactions: a role for fondaparinux

Tan

Thompson

Ekstrom

et al. 2018

Internal Medicine Journal

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Non‐immediate allergic cutaneous reactions to heparins have been increasingly reported, typically manifesting as large, eczematous plaques at sites of subcutaneous injection. Patients may demonstrate cross‐reactivity between unfractionated heparin, low molecular weight heparin and semi‐synthetic heparinoids, making finding an alternative difficult. Fondaparinux has been identified as a useful alternative in such patients; here we present the first two documented cases in Australia and a literature review.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%