Fonsecaea Pedrosoi: A Rare Etiology in Fungal Keratitis

Sangwan, Jyoti; Lathwal, Sumit; Juyal, Deepak; Sharma, Neelam

doi:10.7860/jcdr/2013/6627.3491

Cited by 11 publications

(19 citation statements)

References 7 publications

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“…However, corneal infections caused by this dematiaceous fungus have only been observed in a few cases. In the ophthalmic literature, a few reports including one case series have focused on F. pedrosoi keratitis [ 6 , 7 , 8 , 9 , 10 ]. In this report, we describe 2 cases of F. pedrosoi keratitis, both presenting after eye trauma, including clinical features, case management, and treatment outcome.…”

Section: Introductionmentioning

confidence: 99%

Corneal Chromoblastomycosis Caused by Fonsecaea pedrosoi

Chaidaroon

Tananuvat

Chavengsaksongkram

et al. 2015

Case Rep Ophthalmol

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Purpose: To report 2 unusual cases of fungal keratitis due to Fonsecaea pedrosoi. Methods: Two patients were diagnosed with Fonsecaea pedrosoi keratitis. Their files were reviewed for predisposing factors, clinical characteristics, microbiological study, treatment, and outcome. Results: Two consecutive patients presented with brownish pigmented corneal ulcers in their eyes after sustaining eye trauma from vegetative matter. In both cases, corneal scrapings were collected for microscopic examination and culture. Dematiaceous hyphae were seen on the smears, and dark pigmented colonies grew on the culture media, identified as F. pedrosoi. Both patients were treated and cured with combined topical antifungal agents and oral itraconazole. The first patient required an amniotic membrane patch, while the second received an intracameral amphotericin B injection. Conclusions: Pigmented infiltrates can be an important diagnostic clue, but a microscopic evaluation and culture are required to obtain an accurate diagnosis of Fonsecaea keratitis. The prompt diagnosis and combined antifungal treatment can prevent morbidity associated with this fungal infection.

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Section: Introductionmentioning

confidence: 99%

Corneal Chromoblastomycosis Caused by Fonsecaea pedrosoi

Chaidaroon

Tananuvat

Chavengsaksongkram

et al. 2015

Case Rep Ophthalmol

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“…Fonsecaea Pedrosoi is a dematiaceous fungi and a primary etiological agent for cutaneous chromoblastomycosis. In India, very few cases of corneal chromoblastomycosis were reported in literature including one case series on F. pedrosoii [3][4][5][6]10]. Men are involved more commonly than women, and agricultural workers and outdoor manual labourers constituted the largest affected occupational group as seen in our case [11,12].…”

Section: Discussionmentioning

confidence: 74%

“…Fungal infection of cornea primarily affecting the corneal epithelium and stroma are known as mycotic keratitis which in severe cases can involve endothelium and anterior chamber of eye [2]. Corneal infection due to Fonsecaea pedrosoi is very rare and a few cases of infection are reported in the literature [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Fonsecaea spp. in a Case of Corneal Ulcer - A Case Report from a Tertiary Care Hospital, New Delhi

Malhotra¹

2017

OAJO

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Despite F. pedrosoii being the most common agent of cutaneous blastomycosis, there are few reports of ocular infection by this agent in the literature. This article describes an unusual case of keratitis due to Fonsecaea pedrosoi, which developed after corneal trauma. The patient was a 35-year-old man who presented with a corneal ulcer in the right eye, after sustaining an injury caused by raw vegetable matter. Corneal scrapings were collected for smear and culture examinations. Dematiaceous hyphae were seen on wet mounts of the scrapings, and dark pigmented colonies grew on the culture media. Isolate was identified as Fonsacea pedrosoi.

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“…pedrosoi associated chromoblastomycosis have been often reported in the literature furthermore cerebral granuloma, brain abscess, keratitis and septic arthritis which are secondary to F. pedrosoi have been published [6][7][8][9] .…”

Section: Discussionmentioning

confidence: 99%

Fonsecaea pedrosoi: A rare cause of dental infection and maxillary osteomyelitis in a child with acute lymphoblastic leukemia

et al. 2016

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SUMMARY: Tural-Kara T, Özdemir H, İnce E, İleri T, Çiftçi E. Fonsecaea pedrosoi: A rare cause of dental infection and maxillary osteomyelitis in a child with acute lymphoblastic leukemia. Turk J Pediatr 2016; 58: 679-682.Dental lesions are commonly seen in children with malignancy. We report a child with acute lymphoblastic leukemia who had black-brown dental lesion during the febrile neutropenic episode. Histopathological examination of dental lesion showed fungal hyphae and conidia. F. pedrosoi that was isolated from the tissue culture. The patient was treated with intravenous liposomal amphotericin B therapy for 5 weeks and he was discharged on oral voriconazole. On follow-up, clinical symptoms recovered. Although F. pedrosoi may be an unusual causative agent of dental infection and maxillary osteomyelitis, it should be considered in patient with black-brown lesions which do not respond to antibacterial treatment. Key words: acute lymphoblastic leukemia, children, dental infection, Fonsecaea pedrosoi, osteomyelitis.Patients with acute myeloid leukemia, relapsed leukemia, those receiving highly myelosuppressive chemotherapy and allogeneic hematopoietic stem cell transplant recipients have high risk for fungal infections. Even though invasive fungal infection related mortality can be reduced with prophylactic antifungal therapy, it still continues to be a major cause of morbidity and mortality in neutropenic patients 1 . The incidence of fungal infections in acute lymphoblastic leukemia (ALL) is reportedly 24% and it can increase with prolonged duration of neutropenia 2 . C h r o m o b l a s t o m y c o s i s p e r s e , i s a n infection of skin and subcutaneous tissue 3 .Chromoblastomycosis is a well-established disease caused by F. pedrosoi and have just a few case reports. However, F. pedrosoi associated dental infections and maxillary osteomyelitis have not been reported. To our knowledge, this is the first reported pediatric case of dental infection and maxillary osteomyelitis caused by F. pedrosoi. Case ReportA 6-year-old boy with a diagnosis of standard risk B precursor ALL presented with fever on the 43 rd day of delayed intensification therapy as per COG AALL0331 chemotherapy regimen. On physical examination, he was febrile and pale. His vital signs included a temperature of 39 ºC, heart rate of 128 beats per minute, respiratory rate of 32 breaths per minute, and a blood pressure of 86/52 mmHg. He had 3 cm hepatomegaly below the right costal margin and 2 cm splenomegaly below the left costal margin. The rest of physical examination was normal, and no infectious focus was detected. Patient's laboratory test results were as followed; hemoglobin 11.7 g/dl, white blood cell count 0.2x10 3 /mm 3 , absolute neutrophil count 0/mm 3 (neutrophils 0%, lymphocytes 90%, monocytes 4% and eosinophils 6%), platelet count 16x10 3 /mm 3 , C-reactive protein 62 mg/L. He was started on intravenous cefoperazone-sulbactam for fever and neutropenia. The following day, intravenous teicoplanin and acyclovir were

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Fonsecaea Pedrosoi: A Rare Etiology in Fungal Keratitis

Cited by 11 publications

References 7 publications

Corneal Chromoblastomycosis Caused by Fonsecaea pedrosoi

Corneal Chromoblastomycosis Caused by Fonsecaea pedrosoi

Fonsecaea spp. in a Case of Corneal Ulcer - A Case Report from a Tertiary Care Hospital, New Delhi

Fonsecaea pedrosoi: A rare cause of dental infection and maxillary osteomyelitis in a child with acute lymphoblastic leukemia

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