Food allergy

Wang, Julie; Sampson, Hugh A.

doi:10.1172/jci45434

Cited by 152 publications

(152 citation statements)

References 105 publications

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“…The relationship between the immune mechanism of hypersensitivity reactions and the clinical manifestation and family history of allergic conditions observed in the present study is similar to that reported in the literature [36][37][38].…”

Section: Discussionsupporting

confidence: 91%

Patient characteristics of children with cow’s milk allergy presenting with an allergy to extensively hydrolyzed whey and/or casein formulae used as part of an elimination diet

Nowacki¹

2012

pdia

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A Ad dd dr re es ss s f fo or r c co or rr re es sp po on nd de en nc ce e: : Zygmunt Nowacki MD, PhD, Allergological-Pediatric Practice, Original paper A b s t r a c t I In nt tr ro od du uc ct ti io on n: : In the recent years the number of children with cow's milk protein allergy (CMPA) presenting with allergies to extensively hydrolyzed whey (eHF-W) and casein formulae (eHF-C) respectively has increased. A Ai im m: : To present the patient characteristics of children with CMPA who presented with allergic reactions to eHF-W and/or eHF-C used as part of an elimination diet. M Ma at te er ri ia al l a an nd d m me et th ho od ds s: : A retrospective study was carried out for a group of 65 selected from of 359 children (3 to 12 months) affected with CMPA and allergy to eHF. R Re es su ul lt ts s: : 18.1% (65/359) and 7.8% (28/359) from the group presented with allergic reactions to eHF-W and eHF-C, respectively. An allergic reaction to eHF-C occurred in 43% of the patients from the group (28/65). IgE-mediated CMPA presented with one of the following clinical manifestations: atopic dermatitis (AD) 94%, gastrointestinal symptoms (GI) 47%, respiratory symptoms (RS) 44%, anaphylactic reactions (AR) 26%. Non-IgE-mediated CMPA, on the other hand, manifested with: AD 97%, GI 22%, RS 10% .The observations showed that all 31 from the non-IgE mediated CMPA group with GI and AD manifestations presented with symptoms of eHF-C allergy (p = 0.001). In the IgE-mediated CMPA (n = 34) the following factors were statistically significant with relation to eHF-C allergy: CMPA manifesting with GI (p = 0.014) and AD. The occurrence of AR in response to cow's milk protein (CMP) decreased the probability of an eHF-C allergy (p = 0.028) in a statistically significant way. C Co on nc cl lu us si io on ns s: : Children with CMPA who presented with allergies to eHF-W and eHF-C had a higher frequency of clinical manifestation with GI and AD. K Ke ey y w wo or rd ds s: : cow's milk allergy, elimination diet.

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Section: Discussionsupporting

confidence: 91%

Patient characteristics of children with cow’s milk allergy presenting with an allergy to extensively hydrolyzed whey and/or casein formulae used as part of an elimination diet

Nowacki¹

2012

pdia

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“…SPT of a panel of common allergens was performed in patients with sufficient intact/noninflamed skin (n = 14) and compared with standard clinical positive and negative controls. Because 3 individuals had (51,52). These responses were observed in Was -/-mice on 3 different genetic backgrounds, independent of colonic inflammation, and occurred similarly in mice that were housed under GF settings when compared with those colonized with an SPF flora.…”

Section: Methodsmentioning

confidence: 82%

FOXP3+ Tregs require WASP to restrain Th2-mediated food allergy

Lexmond¹,

Goettel²,

Lyons³

et al. 2016

Journal of Clinical Investigation

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“…In children, the most common foods able to trigger an immunological response include, but are not limited to, cow's milk, hen's egg, peanut, soybeans, wheat, fish, and tree nuts. Whereas, in adults, the most common food allergies are due to ingestion of peanuts, tree nuts, fish, and shellfish [99][100][101]. In people, most commonly food allergy started in the first 3 years of life; however, several studies have shown that most allergies that begin early in life (e.g., milk, egg, soy, and wheat) are generally outgrown.…”

Section: Food Allergymentioning

confidence: 99%

Animal Models of Allergic Diseases

Santoro

Marsella

2014

Veterinary Sciences

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Allergic diseases have great impact on the quality of life of both people and domestic animals. They are increasing in prevalence in both animals and humans, possibly due to the changed lifestyle conditions and the decreased exposure to beneficial microorganisms. Dogs, in particular, suffer from environmental skin allergies and develop a clinical presentation which is very similar to the one of children with eczema. Thus, dogs are a very useful species to improve our understanding on the mechanisms involved in people's allergies and a natural model to study eczema. Animal models are frequently used to elucidate mechanisms of disease and to control for confounding factors which are present in studies with patients with spontaneously occurring disease and to test new therapies that can be beneficial in both species. It has been found that drugs useful in one species can also have benefits in other species highlighting the importance of a comprehensive understanding of diseases across species and the value of comparative studies. The purpose of the current article is to review allergic diseases across species and to focus on how these diseases compare to the counterpart in people.

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Food allergy

Cited by 152 publications

References 105 publications

Patient characteristics of children with cow’s milk allergy presenting with an allergy to extensively hydrolyzed whey and/or casein formulae used as part of an elimination diet

Patient characteristics of children with cow’s milk allergy presenting with an allergy to extensively hydrolyzed whey and/or casein formulae used as part of an elimination diet

FOXP3+ Tregs require WASP to restrain Th2-mediated food allergy

Animal Models of Allergic Diseases

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