Food allergy among Iranian children with inflammatory bowel disease: A preliminary report

Imanzadeh, Farid; Nasri, Parto; Sadeghi, Somayeh; Sayyari, Aliakbar; Dara, Naghi; Karimi, Abdollah; Nilipoor, Yalda; Mansuri, Mahbubeh; Khatami, Katayoon; Rouhani, Pejman; Olang, Beheshteh

doi:10.4103/1735-1995.170605

Cited by 23 publications

(8 citation statements)

References 24 publications

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“…35.7% of the above patients demonstrated allergy to more than one food allergen. The most common allergen was cow’s milk protein [48]. In the authors’ own study, the corresponding parameters were lower and their values were 32% and 23%, respectively.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of allergic diseases in children with inflammatory bowel disease

Wasielewska¹,

Dolińska²,

Wilczyńska³

et al. 2019

pdia

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Introduction There are many similarities between inflammatory bowel disease (IBD) and allergic diseases, including similar epidemiological data, pathomechanism, clinical course and even treatment methods. So far, many studies of IBD comorbidity with other diseases, including allergy, but mainly in adults, have been conducted. Aim To analyse the prevalence of allergic diseases, i.e. food allergy (FA), cow’s milk allergy (CMA), atopic dermatitis (AD), allergic rhinitis (AR) and asthma in children with IBD. Material and methods The study included 105 IBD patients from the Department of Paediatrics, Allergology and Gastroenterology of Collegium Medicum in Bydgoszcz and 100 children without IBD from the Outpatient Clinics. The authors applied the validated questionnaire as a study method. Results At least one allergic disease was found in 26 (43%) IBD children. The allergological diagnosis was made in IBD children more frequently than in the control group ( p = 0.04). The difference was more noticeable with regards to skin prick tests ( p = 0.02). FA was the most common disease; it was noted in 19 (32%) IBD children; followed by: AD – in 13 (22%), CMA – in 12 (20%), AR – in 10 (17%) and asthma – in 6 (10%) children. The prevalence of allergic diseases in the control and study groups was comparable ( p > 0.05). There was no correlation between age of IBD children and allergy ( p > 0.05). Asthma was significantly more common in children undergoing biological treatment ( p = 0.01). Conclusions Children with IBD should be constantly monitored by medical professionals, not only due to the underlying disease but also due to a possible concomitant allergic disease.

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Section: Discussionmentioning

confidence: 99%

Prevalence of allergic diseases in children with inflammatory bowel disease

Wasielewska¹,

Dolińska²,

Wilczyńska³

et al. 2019

pdia

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“…A portion of IBD patients reported that they were prescribed antibiotics in the last 2–5 years before the IBD symptoms occurred 3 . Food allergy (FA) may be another possible cause of IBD 4 as mast cells can be sensitized by the antigen-specific IgE. Re-exposure to specific antigens can activate mast cells and induce mast cells to release proinflammatory cytokines and some other chemical mediators such as tumor necrosis factor-α, which are sufficient to induce intestinal inflammation.…”

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confidence: 99%

Specific immunotherapy plus Clostridium butyricum alleviates ulcerative colitis in patients with food allergy

Lan

Yang

et al. 2016

Sci Rep

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The aberrant T cell activation plays an important role in the pathogenesis of intestinal inflammation, such as ulcerative colitis (UC). C. butyricum (Cb) is a probiotic and has been employed in the treatment of immune diseases. This study tests a hypothesis that specific immunotherapy (SIT) plus oral Cb (an over-the-counter probiotic) alleviates the UC symptoms. In this study, we conducted a randomized, double-blind, clinical study at our hospital. A total of 80 patients with relapsing-remitting ulcerative colitis and high levels of specific IgE antibody was randomly divided into 4 groups, and were treated with SIT or/and Cb, or placebo, respectively for 1 year. The results showed that a food antigen-specific Th2 polarization immune response was observed in UC patients with food allergy (FA). The frequency of regulatory B cells was significantly less in UC patients with FA as compared with healthy subjects. The UC patients with FA were treated with SIT and Cb showed significant amelioration of UC clinical symptoms, reduction of using UC-control medicines, and suppression of the skewed Th2 polarization, which did not occur in those treated with either SIT alone, or Cb alone, or placebo. In conclusion, combination of SIT and Cb efficiently alleviates a fraction of UC patients.

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“…Oxidative stress, allergy, psychological factors, platelets, LTB4, iNOS, and NF-κB are involved in pathogenesis of IBD. [92939495] Herbal medicines have shown to improve these parameters by several mechanisms, including antioxidant activity, inhibition of IKK or NF-κB, suppression of LTB4, inhibition of platelets, and iNOS activities.…”

Section: Resultsmentioning

confidence: 99%

Phytotherapies in inflammatory bowel disease

Ganji-Arjenaki

Rafieian-Kopaei

2019

J Res Med Sci

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Inflammatory bowel disease (IBD) has been considered as a group of heterogeneous intestinal diseases that affects multiple organs outside of the gastrointestinal tract and is due to an uncontrolled inflammatory response mediated by the immune system. The IBD etiology has not been clearly defined, and it is considered as a multifactorial disease. Due to side effects of some conventional therapies, the consumption of complementary and alternative medicines, and in particular, the herbal therapy, more than before is increasing. Herbal therapy results for management of IBD by various mechanisms including leukotriene B4 inhibition, antioxidant activity, immune system regulation of nuclear factor-kappa B, as well as antiplatelet activity are favorable, and no unfortunate events have been yet reported. In this article, we aimed to review and report the herbal therapies established for management of human IBD or evaluated by animal IBD models. Their possible mechanisms of actions are also discussed.

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Food allergy among Iranian children with inflammatory bowel disease: A preliminary report

Cited by 23 publications

References 24 publications

Prevalence of allergic diseases in children with inflammatory bowel disease

Prevalence of allergic diseases in children with inflammatory bowel disease

Specific immunotherapy plus Clostridium butyricum alleviates ulcerative colitis in patients with food allergy

Phytotherapies in inflammatory bowel disease

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