Food and Drug Interactions: A General Review

Ötleş, Semih; Senturk, AhmetSenturk

doi:10.17306/j.afs.2014.1.8

Cited by 51 publications

(54 citation statements)

References 15 publications

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“…A factor that is often proposed to contribute to this variation is diet (Won et al, 2010;Boullata and Hudson, 2012;Ötles and Senturk, 2014). Until recently, knowledge regarding food-drug interactions was primarily based on anecdotal accounts.…”

Section: Introductionmentioning

confidence: 99%

Calorie Restriction Increases P-Glycoprotein and Decreases Intestinal Absorption of Digoxin in Mice

Renaud

Klaassen

Csanaky

2016

Drug Metabolism and Disposition

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There is wide variation in how patients respond to therapeutics. Factors that contribute to pharmacokinetic variations include disease, genetics, drugs, age, and diet. The purpose of this study was to determine the effect of calorie restriction on the expression of Abcb1a in the intestine and whether calorie restriction can alter the absorption of an Abcb1a substrate (i.e., digoxin) in mice. Ten-week-old C57BL/6 mice were given either an ad libitum diet or a 25% calorie-restricted diet for 3 weeks. To determine digoxin absorption, mice were administered [ 3 H]-labeled digoxin by oral gavage. Blood and intestine with contents were collected at 1, 2, 4, and 12 hours after digoxin administration. Concentrations of [ 3 H]-digoxin in plasma and tissues were determined by liquid scintillation. Calorie restriction decreased plasma digoxin concentrations (about 60%) at 1, 2, and 4 hours after administration. Additionally, digoxin concentrations in the small intestine of calorie-restricted mice were elevated at 4 and 12 hours after administration. Furthermore, calorie restriction increased Abcb1a transcripts in the duodenum (4.5-fold) and jejunum (12.5-fold). To confirm a role of Abcb1a in the altered digoxin pharmacokinetics induced by calorie restriction, the experiment was repeated in Abcb1a/ b-null mice 4 hours after drug administration. No difference in intestine or plasma digoxin concentrations were observed between ad libitumfed and calorie-restricted Abcb1a/b-null mice. Thus, these findings support the hypothesis that calorie restriction increases intestinal Abcb1a expression, leading to decreased absorption of digoxin in mice. Because Abcb1a transports a wide variety of therapeutics, these results may be of important clinical significance.

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Section: Introductionmentioning

confidence: 99%

Calorie Restriction Increases P-Glycoprotein and Decreases Intestinal Absorption of Digoxin in Mice

Renaud

Klaassen

Csanaky

2016

Drug Metabolism and Disposition

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“…Otles et al showed in their study that the effects of some drugs can change when they are used on a full or an empty stomach. If the medication has no guiding label, the patients must ask their physician whether to take the drug on a full or an empty stomach [4]. The following causes were found in the present study to be influential in the occurrence of food and drug interactions: the lack of knowledge of health care personnel, high number of inpatients, and lack of enough time, which will all lead to less patients training on food and drug interactions by the doctors and nurses.…”

Section: Discussionmentioning

confidence: 73%

“…Since the nature of health care services is collaborative and teamwork and the pharmacotherapy process is an interdisciplinary process, many people can contribute to the occurrence of such mistakes [18]. Otles et al also found that pharmacists should be aware of the need to monitor food and drug interactions and provide counseling to patients on the consumption of food and beverages along with the prescribed drugs [4]. The potential clinical relevance of food and drug interactions should be recognized for each patient by the physician, nurse, pharmacist, and nutritionist who are members of the treatment team in order to establish an appropriate treatment regimen.…”

Section: Discussionmentioning

confidence: 99%

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Survey of adherence to time standards to prevent food and drug interaction in the hospitalized patients

Abdollahi¹,

Salehi²,

Taherzadeh³

et al. 2018

J Research Health

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Nowadays, food and medicine are two key elements in treatment and prevention of diseases. It is necessary to pay attention to food and drug interactions in order to create ideal conditions for drug effects and provide normal nutritional status to prevent unwanted interactions between food and drug. This study aimed to investigate the range of observing standards of food and drug interactions in hospitalized patients. This study was conducted on 400 hospitalized patients. Data gathering tool included a checklist comprising two sections one of which was used to list demographic data and the other one to record food and drug interaction of 19 commonly prescribed medications using inquiries. According to data from participants who had to take medicine with full stomach, the following interactions were observed: Among the 19 widely consumed medicine in the internal hospital ward, only 2 (10%) were used completely according to the instructions for use of the medication on given meal (magnesium hydroxide and salicylic acid) and in relation to other medications, a maximum of 72.1% matching was observed (omeprazole). Based on the findings of this study, following the guidelines for timely medication administration was not met in the hospitalized patients. To strengthen adherence to fooddrug interactions guidelines and make alliance between health care providers and the establishment of regular team, ongoing education of health professionals is recommended.

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“…Thus, the side effects may increase due to the increase or decrease of systemic drug exposure, or the treatment process may be adversely affected (20,23). For example, grapefruit juice, which is one of the most investigated foods, holds an important place in literature on nutrientdrug interactions because it inhibits the activity of cytochrome enzymes in the small intestine through furanocoumarins in its composition (24,25).…”

Section: Drugs Used In Pregnancy and Drug-nutritional Element Interacmentioning

confidence: 99%

Physiological and Pharmacokinetic Alterations and Drug-Nutrient Interactions During Pregnancy

Ede¹,

Ünal²

2017

Istanbul Med J

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During pregnancy, a large part of the body is affected by the physiological and anatomical changes that start in early pregnancy. Many of these changes significantly affect the pharmacokinetic (absorption, distribution, metabolism, and excretion) and pharmacodynamic properties of different drugs (1-3). During treatment, the use of medicines with the content of only some active ingredients is important to ensure maternal and fetal safety during pregnancy (4-6).Drug-nutritional element interactions are defined as the physicochemical, physiological, and pathophysiological relationships between a drug and nutritional element or between a drug and multiple nutritional elements, nutrients, and constituents or the nutritional status in a broader sense (6-8). Drug-nutritional element interactions can occur in four steps: extracellular bioinactivation, decrease/increase in absorption, decrease/increase in efficacy, and decrease/ increase in excretion (elimination) (7). Therefore, the fact that health professionals consider the physiological changes and the factors affecting the distribution of the drug in the body during pregnancy is important to ensure the effectiveness of pharmacotherapy. In this review article, we aimed to investigate the effects of physiological changes during pregnancy on the pharmacokinetic properties of the drug and the interactions of drugs, nutrients, and nutritional elements. Physiological Changes and Drug Metabolism in PregnancyPregnancy is a process in which many physiological differentiations occur in the cardiovascular, respiratory, excretory, gastrointestinal, and circulatory systems, which alter the interactions of nutrition, nutritional element, and drug metabolism. In summary, the rate and volume of the heart increase, lung capacity decreases, glomerular filtration rate (GFR) increases, blood volume increases, blood circulation decreases, and gastrointestinal system (GIS) motility decreases; in addition, changes, such as nausea and vomiting, occur affecting nutrition. The physiological changes associated with pregnancy are summarized in Table 1. During pregnancy, the interactions between drug metabolism and nutrition and nutritional element may be pharmaceutical, pharmacokinetic, and pharmacodynamic. The pharmaceutical interactions occur within the delivery medium, such as enteral tube or gastrointestinal lumen. This can affect the bioavailability of the drug or nutritional element (8). The pharmacokinetic interactions include the processes of absorption, distribution, metabolism, and excretion of the drug or nutritional element. The pharmacodynamic interactions include physiological changes Physiological and Pharmacokinetic Alterations and DrugNutrient Interactions During PregnancyDuring pregnancy, many physiological and metabolic alterations occur to support the requirements of the developing fetus. Alterations associated with the respiratory, cardiovascular, hematological, urinary, and gastrointestinal systems (GIS) may result in pregnancy-related disorders and may change the pharmac...

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Food and Drug Interactions: A General Review

Cited by 51 publications

References 15 publications

Calorie Restriction Increases P-Glycoprotein and Decreases Intestinal Absorption of Digoxin in Mice

Calorie Restriction Increases P-Glycoprotein and Decreases Intestinal Absorption of Digoxin in Mice

Survey of adherence to time standards to prevent food and drug interaction in the hospitalized patients

Physiological and Pharmacokinetic Alterations and Drug-Nutrient Interactions During Pregnancy

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