Food and Mood: the Corresponsive Effect

Alammar, Welayah A.; Albeesh, Fatima H.; Khattab, Rabie

doi:10.1007/s13668-020-00331-3

Cited by 35 publications

(33 citation statements)

References 108 publications

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“…The mode of action of caffeine is related to binding to adenosine receptors [ 21 ] and inducing psychomotor stimulant properties in the brain [ 19 ]. The beneficial effects of caffeine comprise improved alertness, mood and performance, reduced fatigue and alleviated effects of sleep deprivation [ 22 , 23 , 24 ], although its excessive consumption can lead to several side effects [ 21 , 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Application of the Solute–Solvent Intermolecular Interactions as Indicator of Caffeine Solubility in Aqueous Binary Aprotic and Proton Acceptor Solvents: Measurements and Quantum Chemistry Computations

2022

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The solubility of caffeine in aqueous binary mixtures was measured in five aprotic proton acceptor solvents (APAS) including dimethyl sulfoxide, dimethylformamide, 1,4-dioxane, acetonitrile, and acetone. The whole range of concentrations was studied in four temperatures between 25 °C and 40 °C. All systems exhibit a strong cosolvency effect resulting in non-monotonous solubility trends with changes of the mixture composition and showing the highest solubility at unimolar proportions of organic solvent and water. The observed solubility trends were interpreted based on the values of caffeine affinities toward homo- and hetero-molecular pairs formation, determined on an advanced quantum chemistry level including electron correlation and correction for vibrational zero-point energy. It was found that caffeine can act as a donor in pairs formation with all considered aprotic solvents using the hydrogen atom attached to the carbon in the imidazole ring. The computed values of Gibbs free energies of intermolecular pairs formation were further utilized for exploring the possibility of using them as potential solubility prognostics. A semi-quantitative relationship (R2 = 0.78) between caffeine affinities and the measured solubility values was found, which was used for screening for new greener solvents. Based on the values of the environmental index (EI), four morpholine analogs were considered and corresponding caffeine affinities were computed. It was found that the same solute–solvent structural motif stabilizes hetero-molecular pairs suggesting their potential applicability as greener replacers of traditional aprotic proton acceptor solvents. This hypothesis was confirmed by additional caffeine solubility measurements in 4-formylmorpholine. This solvent happened to be even more efficient compared to DMSO and the obtained solubility profile follows the cosolvency pattern observed for other aprotic proton acceptor solvents.

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Section: Introductionmentioning

confidence: 99%

Application of the Solute–Solvent Intermolecular Interactions as Indicator of Caffeine Solubility in Aqueous Binary Aprotic and Proton Acceptor Solvents: Measurements and Quantum Chemistry Computations

2022

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“…Low E2 dysregulates mood. To elevate the mood, craving for junk foods and processed sweets is evident in middle-aged Indian males that are re ected through the elevated HRVScore [41]. It is another interesting nding of this research.…”

Section: Discussionmentioning

confidence: 69%

Statistical Validation of LENS: Towards Understanding the Empty Nest Syndrome in India using Lyfas, an Optical Biomarker-based Smartphone Biomedical Tool

Chattopadhyay¹,

Das²

2022

Preprint

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Background Empty Nest Syndrome (ENS) is not a listed clinical entity in DSM-5, although ICD-11 has listed it under “Other Associated Problems with Social or Cultural Environment”. However, a complex grief state is observed in the parents when their children leave home for study and work or marriage. Literature shows ENS may progress to clinical-grade depression and anxiety, if left uncared. Methods The study presents a solution (LENS) to assess such risks in ENS using Cardiovascular Optical Biomarkers (COB) from the capillary blood flow signal of the index finger using the technique of arterial photoplethysmography when the finger is gently pressed on the phone camera with the torchlight ‘on’. The scores of COB provide the psychological and metabolic snapshots of the mind-body homeostasis. Results The study observes that (a) COB (e.g., SD1/SD2, LF/HF, HRVScore, and ENERGY), obtained through Lyfas tests, and (b) physical e.g., Diastolic Blood Pressure, BMI, Heart rate, HbA1c, TSH, and Estradiol have significant roles in the backdrop of ENS. Bland Altman's reliability measure shows that LENS (novel instrument under trial) has a high agreement of 92.85% and 93.86%, respectively with ENS scoring done by senior psychologists (champion instrument – 1) and HAM-D grading performed by psychiatrists (champion instrument – 2). Conclusions LENS can be used as an assistive tool to screen and monitor ENS cases in a health set up.

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“…Bioactive compounds found in a healthy diet, particularly in a FV-rich diet, such as vitamins (i.e., B and C vitamins), minerals (i.e., zinc, magnesium) and fiber (i.e., resistant starch), have been linked to health and well-being ( 21 ). These constituents appear to play a protective role on mental health conditions ( 11 ), modulating some of the neurotransmitters in the brain, which regulate mood ( 21 ) and could potentially increase joy and happiness ( 64 ). Some neurochemicals (e.g., endorphin, dopamine, serotonin, norepinephrine, and melatonin) have been shown to cause feelings of happiness ( 22 ).…”

Section: Discussionmentioning

confidence: 99%

“…It is noteworthy that this relationship is likely to be bidirectional, as stress can also lead to overeating ( 17 , 18 ) and poor dietary choices, such as increased intake of sugar and fat-rich foods ( 19 , 20 ). Growing evidence suggests that adherence to a healthy diet (e.g., rich in FV and low in sugar and fat) may improve well-being ( 21 ). Bioactive compounds found in FV, such as vitamins (e.g., B and C vitamins), minerals (e.g., zinc, magnesium) and fiber seem to modulate neurochemicals (e.g., endorphin, dopamine, serotonin, and norepinephrine) in the brain that promote feelings of happiness ( 22 ).…”

Section: Introductionmentioning

confidence: 99%

Higher Consumption of Fruit and Vegetables Is Associated With Lower Worries, Tension and Lack of Joy Across the Lifespan

et al. 2022

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Background and AimsHigher total fruit and vegetable (FV) intakes have been associated with lower perceived stress. However, the relationship of FV intake with domains of perceived stress is unclear. The aim of this cross-sectional study was to explore the relationship between consumption of FV and four perceived stress domains (worries, tension, lack of joy and demands) in a population-based cohort of Australian adults.MethodsParticipants (n = 8,640) were men and women aged ≥25 years from the Australian Diabetes, Obesity and Lifestyle (AusDiab) Study. Dietary intake was assessed using a 74-item validated Food Frequency Questionnaire. Perceived stress domains were determined using a validated 20-item version of the Perceived Stress Questionnaire, with higher scores representing higher perceived stress. Cut-offs for high perceived stress domains were obtained from the highest quartiles of each domain for each sex. Multivariable-adjusted logistic regression was performed to investigate cross-sectional associations.ResultsThe mean age of participants (50.1% females) was 47.8 (SD 15) years. Those with higher intakes of FV, combined and separately, had a significantly lower odds (16–36%) for higher worries, tension and lack of joy, independent of other lifestyle factors.ConclusionIn Australian adults, higher consumption of FV was associated with lower odds of worries, tension and lack of joy. Following the dietary guidelines for the recommended intake of FV may help improve feelings of worries, tension and lack of joy, which are linked to mental health problems.

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Food and Mood: the Corresponsive Effect

Cited by 35 publications

References 108 publications

Application of the Solute–Solvent Intermolecular Interactions as Indicator of Caffeine Solubility in Aqueous Binary Aprotic and Proton Acceptor Solvents: Measurements and Quantum Chemistry Computations

Application of the Solute–Solvent Intermolecular Interactions as Indicator of Caffeine Solubility in Aqueous Binary Aprotic and Proton Acceptor Solvents: Measurements and Quantum Chemistry Computations

Statistical Validation of LENS: Towards Understanding the Empty Nest Syndrome in India using Lyfas, an Optical Biomarker-based Smartphone Biomedical Tool

Higher Consumption of Fruit and Vegetables Is Associated With Lower Worries, Tension and Lack of Joy Across the Lifespan

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