Food-associated cues alter forebrain functional connectivity as assessed with immediate early gene and proenkephalin expression

Schiltz, Craig A.; Bremer, Quentin; Landry, Charles F.; Kelley, Ann E.

doi:10.1186/1741-7007-5-16

Cited by 66 publications

(59 citation statements)

References 128 publications

(94 reference statements)

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“…Work in rats has shown that exposure to external contextual cues associated with highly palatable foods alters connectivity between very similar components of the feeding network (Schiltz et al, 2007). Our current findings demonstrate an analogous Higher-order PPI from the ventral striatum (source region).…”

Section: Discussionsupporting

confidence: 70%

“…The fact that connectivity between components of the feeding network Schiltz et al, 2007;Berthoud and Morrison, 2008) were only fully identified by the EFS regression analyses accords with the role of EFS in responsivity to external food cues (van Strien et al, 1986;Burton et al, 2007;Elfhag et al, 2007Elfhag et al, , 2008. In other words, the large variance in the change of connectivity is accounted for by individual differences in EFS, with relative decreases as a function of EFS.…”

Section: Analysis Of Connectivity: Higher-order Ppis As a Function Ofmentioning

confidence: 68%

“…Because brain regions might be very different in size (in particular subcortical compared with cortical areas), we treated them as separate hypotheses and adjust the significance for multiple hypotheses testing using Dunn-Sidak correction for multiple tests (Howell, 2007). The amygdala, striatum, premotor, and ACC were defined as a priori ROIs based on the animal and human literature showing their key role in feeding behavior and in processing reward stimuli such as foods (Rolls et al, 1980;LaBar et al, 2001;Ehrsson et al, 2003;Killgore et al, 2003;Dresel et al, 2005;Haber et al, 2006;Killgore and Yurgelun-Todd, 2006;Alonso-Alonso and Pascual-Leone, 2007;Berthoud, 2007;Cornier et al, 2007;DelParigi et al, 2007;Schiltz et al, 2007;Berthoud and Morrison, 2008). All ROIs were defined using the Marsbar software incorporating the "aal.02" atlas for automatic anatomical labeling (http:// marsbar.sourceforge.net/) (Tzourio-Mazoyer et al, 2002).…”

Section: Methodsmentioning

confidence: 99%

“…Here, we used psychophysiological interaction (PPI) to address how the physiological connectivity (coupling) between pairs of regions is affected by psychological context (e.g., viewing appetizing vs bland foods) . Of particular relevance, recent work in rats examining the correlation between brain regions expressing "immediate early gene and proenkephalin" (measures of neuronal metabolism) indicates that the connectivity between the amygdala, ventral striatum (nucleus accumbens core) and prefrontal cortex is modulated when animals are exposed to contextual cues associated with appetizing food (Schiltz et al, 2007). These regions are directly anatomically interconnected (Kunishio and Haber, 1994;Friedman et al, 2002;Haber et al, 2006;Barbas, 2007;Ghashghaei et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Personality Predicts the Brain's Response to Viewing Appetizing Foods: The Neural Basis of a Risk Factor for Overeating

Passamonti¹,

Rowe²,

Schwarzbauer³

et al. 2009

J. Neurosci.

123

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Eating is not only triggered by hunger but also by the sight of foods. Viewing appetizing foods alone can induce food craving and eating, although there is considerable variation in this "external food sensitivity" (EFS). Because increased EFS is associated with overeating, identifying its neural correlates is important for understanding the current epidemic of obesity. Animal research has identified the ventral striatum, amygdala, hypothalamus, medial prefrontal and premotor cortices as key interacting structures for feeding. However, it is unclear whether a similar network exists in humans and how it is affected by EFS. Using functional magnetic resonance imaging, we showed that viewing appetizing compared with bland foods produced changes in connectivity among the human ventral striatum, amygdala, anterior cingulate and premotor cortex that were strongly correlated with EFS. Differences in the dynamic interactions within the human appetitive network in response to pictures of appetizing foods may determine an individual's risk of obesity.

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Section: Discussionsupporting

confidence: 70%

Section: Analysis Of Connectivity: Higher-order Ppis As a Function Ofmentioning

confidence: 68%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Personality Predicts the Brain's Response to Viewing Appetizing Foods: The Neural Basis of a Risk Factor for Overeating

Passamonti¹,

Rowe²,

Schwarzbauer³

et al. 2009

J. Neurosci.

123

View full text Add to dashboard Cite

show abstract

“…Stimulation of receptors for ENK within striatal subregions (particularly the nucleus accumbens (Acb)) augments the 'liking' of sweet tastes (Pecina and Berridge, 2005) and enhances the intake of sweet, and/or fat-rich foodstuffs (Woolley et al, 2006;Zhang et al, 1998)-the same types of food whose intake is augmented in sleep loss. Furthermore, endogenous ENK release in rat striatum accompanies the 'binge-like' intake of palatable food (Difeliceantonio et al, 2012), and striatal ENK gene expression is upregulated by palatable food-conditioned cues (Schiltz et al, 2007). ENK and related systems could therefore have an important role in the palatable or high-fat food snacking seen with sleep loss in humans, which appears to be a crucial factor promoting weight gain (Markwald et al, 2013;StOnge et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Upregulation of Gene Expression in Reward-Modulatory Striatal Opioid Systems by Sleep Loss

Baldo

Hanlon

Obermeyer

et al. 2013

Neuropsychopharmacol

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Epidemiological studies have shown a link between sleep loss and the obesity 'epidemic,' and several observations indicate that sleep curtailment engenders positive energy balance via increased palatable-food 'snacking.' These effects suggest alterations in rewardmodulatory brain systems. We explored the effects of 10 days of sleep deprivation in rats on the expression of striatal opioid peptide (OP) genes that subserve food motivation and hedonic reward, and compared effects with those seen in hypothalamic energy balanceregulatory systems. Sleep-deprived (Sleep-Dep) rats were compared with yoked forced-locomotion apparatus controls (App-Controls), food-restricted rats (Food-Restrict), and unmanipulated controls (Home-Cage). Detection of mRNA levels with in situ hybridization revealed a subregion-specific upregulation of striatal preproenkephalin and prodynorhin gene expression in the Sleep-Dep group relative to all other groups. Neuropeptide Y (NPY) gene expression in the hippocampal dentate gyrus and throughout neocortex was also robustly upregulated selectively in the Sleep-Dep group. In contrast, parallel gene expression changes were observed in the Sleep-Dep and Food-Restrict groups in hypothalamic energy-sensing systems (arcuate nucleus NPY was upregulated, and cocaine-and amphetamine-regulated transcript was downregulated), in alignment with leptin suppression in both groups. Together, these results reveal a novel set of sleep deprivation-induced transcriptional changes in reward-modulatory peptide systems, which are dissociable from the energy-balance perturbations of sleep loss or the potentially stressful effects of the forced-locomotion procedure. The recruitment of telencephalic food-reward systems may provide a feeding drive highly resistant to feedback control, which could engender obesity through the enhancement of palatable feeding.

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HPA Axis Interactions with Behavioral Systems

Packard

Egan

Ulrich‐Lai

2016

Comprehensive Physiology

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Perhaps the most salient behaviors that individuals engage in involve the avoidance of aversive experiences and the pursuit of pleasurable experiences. Engagement in these behaviors is regulated to a significant extent by an individual's hormonal milieu. For example, glucocorticoid hormones are produced by the hypothalamic-pituitary-adrenocortical (HPA) axis, and influence most aspects of behavior. In turn, many behaviors can influence HPA axis activity. These bidirectional interactions not only coordinate an individual's physiological and behavioral states to each other, but can also tune them to environmental conditions thereby optimizing survival. The present review details the influence of the HPA axis on many types of behavior, including appetitively-motivated behaviors (e.g., food intake and drug use), aversively-motivated behaviors (e.g., anxiety-related and depressive-like) and cognitive behaviors (e.g., learning and memory). Conversely, the manuscript also describes how engaging in various behaviors influences HPA axis activity. Our current understanding of the neuronal and/or hormonal mechanisms that underlie these interactions is also summarized. © 2016 American Physiological Society. Compr Physiol 6:1897-1934, 2016.

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Food-associated cues alter forebrain functional connectivity as assessed with immediate early gene and proenkephalin expression

Cited by 66 publications

References 128 publications

Personality Predicts the Brain's Response to Viewing Appetizing Foods: The Neural Basis of a Risk Factor for Overeating

Personality Predicts the Brain's Response to Viewing Appetizing Foods: The Neural Basis of a Risk Factor for Overeating

Upregulation of Gene Expression in Reward-Modulatory Striatal Opioid Systems by Sleep Loss

HPA Axis Interactions with Behavioral Systems

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