Food‐dependent exercise‐induced anaphylaxis in Japanese elementary school children

Abstract

FDEIA was far less common in elementary school than in junior-high school, and wheat was the major causative food. The new appearance of DEIA was notable. Decreasing episode recurrence remains an issue that needs to be resolved.

Apport de la protéomique à la connaissance des allergènes impliqués dans l’anaphylaxie induite par l’effort au blé

“…Une étude effectuée en 2013 par questionnaire auprès des infirmières de 317 écoles primaires de Yokohama portant sur 170 146 enfants a permis de suspecter 33 cas d'AAIE avec seulement 8 observations confirmées (7 garçons/1 fille). La prévalence estimée est donc de 0,0047% ou encore 1/20 000 enfants (10). Les allergènes alimentaires concernés étaient le blé (4), les crustacées (1), le calamar (1), le soja (1) et « fruits » (1).…”

“…Cette même équipe japonaise a comparé la prévalence de l'AAIE dans une population plus âgée puisque cette étude concerne 76 534 étudiants de Yokohama (11). La prévalence de l'AAIE s'élève à 0,018% soit 14 cas ou encore 18/10 000 (10). Le sexe ratio est de 1.…”

Exercise‐induced allergic reactions after achievement of desensitization to cow's milk and wheat

“…OIT for CM or wheat effectively achieves desensitization, 6‐9 but exercise after ingestion of the causative antigen can cause immediate allergic symptoms 10‐14 . Manabe et al suggested two types of exercise‐induced allergic symptoms: "food‐dependent exercise‐induced anaphylaxis" 15 and "desensitization status and exercise‐induced anaphylaxis" 10,16 …”

Food-dependent Exercise-induced Anaphylaxis: The Need for Better Understanding and Management of the Disease

“…Wheat is the most common cause of FDEIA, but other grains, seafood, peanut, egg, milk, Rosaceae fruits and vegetables have also been reported as causes of FDEIA. 2 3 In some cases, symptoms may be triggered by any meal followed by exercise regardless of the food type. 4 Although FDEIA is frequently reported in young adults, epidemiologic studies are rare.…”

“…A Japanese group reported the prevalence of FDEIA at 0.017% among junior high school students and 0.0047% among elementary school students. 2 5 In a multicenter anaphylaxis registry in Korea, the proportion of FDEIA was 1.2% and 3.1% in children and adults, respectively. 6 Recently, the concept of FDEIA has been expanded and described as “food-dependent cofactor-augmented anaphylaxis” or “cofactor-induced food allergy.” 7 8 Reported cofactors other than physical exercise are aspirin, other analgesics, alcohol, stress, and infections.…”