Food-deprived activity stress decreased the activity of the histaminergic neuron system in rats

Endou, Masatoshi; Yanai, Kazuhiko; Sakurai, Eiko; Fukudo, Shin; Hongo, Michio; Watanabe, Takehiko

doi:10.1016/s0006-8993(00)03226-1

Cited by 42 publications

(23 citation statements)

References 42 publications

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“…The histamine H 3 receptor has been demonstrated in association with stress-induced brain activity (30,31). Some reports suggested that there are changes of histamine contents and histamine H 1 and H 3 receptors in the brains of mice subjected to fooddeprived stress and revealed that there is a discrepancy between the levels of H 1 and H 3 receptors in the acute and chronic phases of stress conditions (8). Also, histamine nerve systems played a crucial role in maintaining homeostatic energy balance (32,33).…”

Section: Discussionmentioning

confidence: 99%

“…A large number of experimental evidences supported that the histaminergic system performs its physiological functions through H 1 , H 2 , and H 3 receptors (7). Recent studies suggested that the activities of histaminergic neurons are likely to increase the response to stress (8). On one hand, proper stress can enhance biosynthesis and the release of histamine (9).…”

Section: Introductionmentioning

confidence: 99%

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Effects of Histamine on Lipid Metabolic Disorder in Mice Loaded With Restraint Stress

Yao

Wang

et al. 2009

J Pharmacol Sci

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Abstract. The present study was conducted to investigate the effects of histamine on the lipid metabolic disorder in mice loaded with restraint stress. When Kun Ming (KM) mice were exposed to restraint stress for 20 h, the histamine level in both plasma and cerebral regions significantly increased (P<0.01). Moreover, when a lipid emulsion (10% Intralipid ® ) was injected intravenously into the mice, the elimination period of plasma triglyceride was prolonged in the restraint group. Plasma triglyceride was 523 ± 44 mg/dl at 35 min after the Intralipid ® administration in the restraint stress group, while it was 436 ± 41 mg/dl in the restrained mice given histamine at a dose of 50 mg/kg. The improved plasma triglyceride metabolism was well explained by the observations of the significantly up-regulated hepatic triglyceride lipase (HTGL) activity and mRNA expression in response to histamine. These results suggested that the effects of stress-induced histamine on lipid metabolic disorder in mice loaded with restraint stress arose from its anti-stress action and promotion of lipase activity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of Histamine on Lipid Metabolic Disorder in Mice Loaded With Restraint Stress

Yao

Wang

et al. 2009

J Pharmacol Sci

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“…Mazurkiewicz-Kwilecki 12) and Ito et al 13) described that acute stress increases brain histamine turnover, and Endou et al 14) also demonstrated that histamine release was enhanced under stressful conditions. Therefore, we studied the effects of histamine H 1 -antagonist on awake time and non-REM sleep time in rats placed on a grid suspended over water.…”

Section: Discussionmentioning

confidence: 99%

Effects of Histamine H1-Antagonists on Sleep-Awake State in Rats Placed on a Grid Suspended over Water or on Sawdust

Tokunaga

Tsutsui

Obara

et al. 2009

Biological & Pharmaceutical Bulletin

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The present study was performed to investigate the effects of histamine H 1 -antagonists on the sleep-awake state in rats placed on a grid suspended over water in comparison with rats placed on sawdust. When rats were placed on the grid suspended over water, significant increases in the awake time and decreases in non-rapid eye movement (non-REM) sleep time were observed compared with in rats on sawdust, even when measured hourly for 6 h. Diphenhydramine, chlorpheniramine and promethazine caused a significant decrease in the awake time and increase in non-REM sleep time in rats placed on the grid suspended over water for 1-2 h and/or 2-3 h after administration. On the other hand, in rats placed on sawdust, no significant differences were observed in the awake time and non-REM sleep time with diphenhydramine and chlorpheniramine compared with the control. Different from these two drugs, promethazine caused a significant decrease in the awake time and increase in non-REM sleep time 1-2 h and 2-3 h after administration even when rats were placed on sawdust at a relatively high dose. These results clearly indicate that histamine H 1 -antagonists had potent effects on decreasing the awake time and increasing non-REM sleep time under the conditions of an activated histaminergic system.

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“…Noradrenergic, 38,48 histaminergic, 10 and dopaminergic 17 neuronal activity in the hypothalamus are significantly enhanced while serotonergic metabolism was decreased. 17 Additional indirect evidence for the involvement of the hypothalamus comes from the increased activity of the hypothalamic-pituitary adrenal axis in this model.…”

Section: The Hypothalamus and The Activity-based Anorexia Modelmentioning

confidence: 93%

Electrical stimulation in the lateral hypothalamus in rats in the activity-based anorexia model

Welkenhuysen

Kuyck²,

Das³

et al. 2008

FOC

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Object One quarter of patients with anorexia nervosa have a poor outcome and continue to suffer chronically or die. Electrical brain stimulation may be of therapeutic benefit in some of these patients; however, the brain target for inducing symptom relief is unknown. In this study, the authors evaluated the effects of acute and chronic electrical stimulation in the lateral hypothalamus on food intake, locomotor activity, and survival time in rats in an activity-based anorexia model. Methods In an acute experiment, the authors electrically stimulated at 100 Hz and 0, 25, 50 and 75% of the maximal stimulation amplitude (that is, the amplitude leading to severe side effects) in the lateral hypothalamus on consecutive days during 4 test sessions in 10 rats and evaluated food intake and locomotor activity. In a chronic experiment, they compared food intake, wheel revolutions, and survival time between 6 rats that underwent electrical stimulation in the lateral hypothalamus (50% of maximal stimulation amplitude) and 8 rats that did not undergo stimulation. Results In the acute experiment, overall electrical stimulation (25, 50, and 75% combined) and stimulation at 75% of the maximal stimulation amplitude significantly decreased the locomotor activity. However, if the authors omitted results of 1 rat, in which the electrode tip was not located in the lateral hypothalamus on one side but rather in the supraoptic chiasm, the remaining results did not yield significance. No other differences were observed. Conclusions When the findings of the current study are extrapolated to patients with anorexia nervosa, the authors do not expect major effects on symptoms with electrical stimulation at high frequency in the lateral hypothalamus.

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Food-deprived activity stress decreased the activity of the histaminergic neuron system in rats

Cited by 42 publications

References 42 publications

Effects of Histamine on Lipid Metabolic Disorder in Mice Loaded With Restraint Stress

Effects of Histamine on Lipid Metabolic Disorder in Mice Loaded With Restraint Stress

Effects of Histamine H1-Antagonists on Sleep-Awake State in Rats Placed on a Grid Suspended over Water or on Sawdust

Electrical stimulation in the lateral hypothalamus in rats in the activity-based anorexia model

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