Food-Derived Anticancer Peptides: A Review

Sharma, Poorva; Kaur, Harjeet; Kehinde, Bababode Adesegun; Chhikara, Navnidhi; Sharma, Deepansh; Panghal, Anil

doi:10.1007/s10989-020-10063-1

Cited by 54 publications

(29 citation statements)

References 118 publications

(87 reference statements)

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“…It is considered one of the topmost causes of death in the 21st century, though more widespread in developed nations compared to developing countries. Various BAPs have been scientifically verified as potential agents for cancer prevention and therapeutic management [ 120 ]. Peptides having anti-cancer potential comprise a variation in the structural and geometric configuration and, on their surface, bear the properties related to cationic charges along with hydrophobic parts used to attach to specific cell membrane amphiphatically.…”

Section: Therapeutic Potentials Of Milk-derived Bapsmentioning

confidence: 99%

Health-Promoting and Therapeutic Attributes of Milk-Derived Bioactive Peptides

Samtiya

Badgujar

et al. 2022

Nutrients

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Milk-derived bioactive peptides (BAPs) possess several potential attributes in terms of therapeutic capacity and their nutritional value. BAPs from milk proteins can be liberated by bacterial fermentation, in vitro enzymatic hydrolysis, food processing, and gastrointestinal digestion. Previous evidence suggested that milk protein-derived BAPs have numerous health-beneficial characteristics, including anti-cancerous activity, anti-microbial activity, anti-oxidative, anti-hypertensive, lipid-lowering, anti-diabetic, and anti-osteogenic. In this literature overview, we briefly discussed the production of milk protein-derived BAPs and their mechanisms of action. Milk protein-derived BAPs are gaining much interest worldwide due to their immense potential as health-promoting agents. These BAPs are now used to formulate products sold in the market, which reflects their safety as natural compounds. However, enhanced commercialization of milk protein-derived BAPs depends on knowledge of their particular functions/attributes and safety confirmation using human intervention trials. We have summarized the therapeutic potentials of these BAPs based on data from in vivo and in vitro studies.

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Section: Therapeutic Potentials Of Milk-derived Bapsmentioning

confidence: 99%

Health-Promoting and Therapeutic Attributes of Milk-Derived Bioactive Peptides

Samtiya

Badgujar

et al. 2022

Nutrients

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“…Cancer is the serious concern of developing and developed countries due to hectic lifestyle leading to oxidative stress (Sardana, Chhikara, Tanwar, & Panghal, 2018; Sharma et al, 2020). Leaf extract of A. marmelos was found to be effective in inhibiting cancerous cell growth like Erythroleukemic HEL, T‐lymphoid jurkat, Melanoma Colo38, leukemic K562, Breast cancer cell lines (MDA‐MB 231) (isolated at M D Anderson from a pleural effusion of a patient with invasive ductal carcinoma) and Michigan Cancer Foundation‐7 (MCF7) and B‐lymphoid Raji (Lampronti et al, 2003; Rahman & Parvin, 2014).…”

Section: Remedial Importance Of a Marmelosmentioning

confidence: 99%

Bioactive compounds of Aegle marmelos L., medicinal values and its food applications: A critical review

Venthodika¹,

Chhikara

Mann

et al. 2020

Phytotherapy Research

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Aegle marmelos L. (bael) is a fruit tree of Rutaceae family, widely grown all over the world. This plant is gaining popularity because of its nutrient‐rich fruits and immense traditional medicinal usage and pharmacological properties. The health promotive and protective effect of bael fruit is accounted by fibers, carotenoids, phenolics, terpenoids, coumarins, flavonoids, and alkaloids. The curative relevance of these compounds has been assessed by various in vivo and in vitro studies. Fruit shows numerous possible health benefits, namely, radio‐protective effects, peroxidation, antibacterial, inhibition of lipid, antidiarrheal, gastroprotective, antiviral, antidiabetic, anti‐ulcerative colitis, cardioprotective, free‐radical scavenging (antioxidant) and hepatoprotective effects. The health benefits of bael are not only limited to edible portion (fruit), but it also extends to nonedible portion (root, trunk, bark, leaf, flower and seed) having comparable biologically active compounds. Increasing awareness about the role of diet among health‐conscious consumers for human well‐being has increased the interest in functional foods thereby exploration of the functional attributes of various underutilized plants is being reaffirmed and various sources are emerged out as suitable food material for processing industry. The various scientific reports collected from different bibliometric sources suggested that A. marmelos and its bioactive constituents could play a vital role in the prevention of several chronic and degenerative diseases associated with oxidation stress. This review emphasis on recent scientific evidences on nutrition and bioactive profile of A. marmelos, health benefits along with clinical and nonclinical trials of various phytoconstituents and A. marmelos potential in food processing industry for various food products. Our study suggests that this plant does indeed have pharmacological properties of interest, however, further extensive research is needed to establish a potential strategy that can balance the pharmacological and toxic effects of bael.

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“…The World Health Organisation (WHO) reports that cancer cases will rise from 14 million in 2012 to 22 million within two decades (Chalamaiah et al, 2018;Sharma et al, 2020). Chemotherapy is still regarded as the most effective treatment of cancers even though it is costly and has many unavoidable side effects (Chen et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

In vitro antioxidant and apoptotic activity of Lablab purpureus (L.) Sweet isolate and hydrolysates

et al. 2022

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Cancer is a disease that invades the lives of millions of people each year. Chemotherapy is currently the most effective treatment however resulting in many adverse effects to the human body. Alternative treatments are being explored to overcome this obstacle. Peptides that possess radical scavenging activity and bioactive properties can be advantageous in prevention and treatment of chronic diseases. In this study, Lablab purpureus isolate and its hydrolysates (trypsin, pepsin and alcalase) were analysed for radical scavenging potential (DPPH, ABTS, superoxide radical scavenging and FRAP) and antiproliferative activity. Antiproliferative activity was confirmed with the peptides ability to induce apoptosis (Caspase 3/7 activity and Annexin V-PI). The lowest inhibitory concentrations (IC 50 ) for DPPH, ABTS and Superoxide radical scavenging ranged between 1.81-4.47, 1.73-2.42 and 1.36-4.41 mg/mL, respectively. FRAP ranged from 19.20 to 21.94 mg/mL. Generally, it is considered that a good antioxidant encompasses antiproliferative potential. Cell lines, A549, MCF-7 and HEK293, treated with pepsin hydrolysate showed (IC 50 values of 119.6, 9.80 and 13.86 µg/mL). The isolate and pepsin were chosen for apoptotic studies. The pepsin hydrolysate showed the highest inhibition in the cancerous cell lines (A549 and MCF-7) without greatly effecting normal cells (HEK293), and the isolate was selected for comparative analysis. Annexin V-PI staining showed cells in different stages of apoptosis (cells during early apoptosis; A549, 42%; MCF-7, 17%; HEK, 34%). Caspase 3/7 assay demonstrated that the peptide causes an increase in caspase activity. Peptides have the potential to act as chemo-preventative agents due to their antioxidant and apoptotic abilities.

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Food-Derived Anticancer Peptides: A Review

Cited by 54 publications

References 118 publications

Health-Promoting and Therapeutic Attributes of Milk-Derived Bioactive Peptides

Health-Promoting and Therapeutic Attributes of Milk-Derived Bioactive Peptides

Bioactive compounds of Aegle marmelos L., medicinal values and its food applications: A critical review

In vitro antioxidant and apoptotic activity of Lablab purpureus (L.) Sweet isolate and hydrolysates

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