Food-derived bioactive peptides as momentous food components: Can functional peptides passed through the PI3K/Akt/mTOR pathway and NF-κB pathway to repair and protect the skeletal muscle injury?

Di, Chenna; Jia, Wei

doi:10.1080/10408398.2023.2209192

Cited by 4 publications

(3 citation statements)

References 109 publications

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“…The proliferation of muscle cells is an important process in the development of skeletal muscle. C 2 C 12 cell line is the most commonly used mature muscle cell line for muscle study [ 15 ]. It has been reported that collagen dipeptide (Hyp-Gly) can promote the proliferation and differentiation of murine myogenic C 2 C 12 cells [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…C 2 C 12 cell line is the most commonly used mature muscle cell line for muscle study [ 15 ]. It has been reported that collagen dipeptide (Hyp-Gly) can promote the proliferation and differentiation of murine myogenic C 2 C 12 cells [ 15 ]. Recently, bovine collagen peptide (GDAGPPGPAGPAGPPGPIG) have been reported to exhibit a significant impact on the proliferation of C 2 C 12 cells (proliferation rate, 18.5%, p < 0.05) [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

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Zein-Derived Peptides from Corn Promote the Proliferation of C2C12 Myoblasts via Crosstalk of mTORC1 and mTORC2 Signaling Pathways

Amin,

Yu,

et al. 2024

Foods

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Dietary protein supplementation has emerged as a promising strategy in combating sarcopenia. Furthermore, searching for alternatives of animal proteins has been a hot topic. The present study aimed to investigate the effects of zein peptides on C2C12 myoblasts and explore their potential molecular mechanisms. The proliferative, cell cycle, and anti-apoptotic activities of zein peptides were evaluated. Peptidomics analysis and transcriptome sequencing were employed to explore the structure-activity relationship and underlying molecular mechanisms. The results indicated that zein peptides (0.05–0.2 mg/mL) exerted a significant proliferation-promoting impact on C2C12 cells, via increasing cell viability by 33.37 to 42.39%. Furthermore, zein peptides significantly increased S phase proportion and decreased the apoptosis rate from 34.08% (model group) to 28.96% in C2C12 cells. In addition, zein peptides exhibited a pronounced anti-apoptotic effect on C2C12 cells. Zein peptides are abundant in branch-chain amino acids, especially leucine. Transcriptomics analysis revealed that zein peptides can promote proliferation, accelerate cell cycle, and improve protein synthesis of muscle cells through mTORC1 and mTORC2 signaling pathways.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Zein-Derived Peptides from Corn Promote the Proliferation of C2C12 Myoblasts via Crosstalk of mTORC1 and mTORC2 Signaling Pathways

Amin,

Yu,

et al. 2024

Foods

View full text Add to dashboard Cite

show abstract

“…Malnutrition was also reported to be the second factor that influenced the wound healing speed . Wound healing peptides are considered novel therapeutic strategies for effective wound management due to their antioxidant, anti-inflammatory, antibacterial, high specificity, and safety and can be used as a nutrition supplement. – Massive evidence has confirmed that food-derived bioactive peptides, such as sea cucumber peptides, Crassostrea gigas peptides, and egg white peptides (EWP), are efficient in nutrition and injury recovery, especially for wound healing. – Our previous study demonstrated that the administration of EWP by gavage could significantly enhance the wound-healing processes of skin tissues . Still, the underlying regulation molecular mechanism has not been elucidated.…”

Section: Introductionmentioning

confidence: 99%

Egg White Peptides Accelerating the Wound Healing Process Through Modulating the PI3K-AKT Pathway: A Joint Analysis of Transcriptomic and Proteomic

Ge,

Yang,

Lyu

et al. 2024

J. Agric. Food Chem.

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Wound healing is a multiphase process with a complex repair mechanism; trauma-repairing products with safety and high efficiency have a great market demand. Egg white peptides (EWP) have various physiological regulatory functions and have been proven efficient in ameliorating skin damage. However, their underlying regulation mechanism has not been revealed. This study further evaluated the EWP ameliorating mechanism by conducting a full-thickness skin wound model. Results demonstrated that EWP administration significantly inhibited the expression of pro-inflammatory and shortened the inflammatory phase. Besides, EWP can accelerate the secretion of growth factors (PDGF, VEGF, and TGF-β1) in skin tissue, significantly increasing the regeneration of granulation tissue and endothelium in the proliferation phase, thereby promoting wound healing. After 400 mg/kg EWP interventions for 13 days postoperation, the wound healing rate reached 90%. The combination of transcriptomic and proteomic analyses demonstrated the ameliorating efficiency effects of EWP on wound healing. EWP mainly participates in the functional network with the PI3K-AKT signaling pathway as the core to accelerate wound healing. These findings suggest a promising EWP-based strategy for accelerating wound healing.

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Daurisoline inhibits glycolysis of lung cancer by targeting the AKT-HK2 axis

Tan,

Luo,

et al. 2024

Cancer Biology & Therapy

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Food-derived bioactive peptides as momentous food components: Can functional peptides passed through the PI3K/Akt/mTOR pathway and NF-κB pathway to repair and protect the skeletal muscle injury?

Cited by 4 publications

References 109 publications

Zein-Derived Peptides from Corn Promote the Proliferation of C2C12 Myoblasts via Crosstalk of mTORC1 and mTORC2 Signaling Pathways

Zein-Derived Peptides from Corn Promote the Proliferation of C2C12 Myoblasts via Crosstalk of mTORC1 and mTORC2 Signaling Pathways

Egg White Peptides Accelerating the Wound Healing Process Through Modulating the PI3K-AKT Pathway: A Joint Analysis of Transcriptomic and Proteomic

Daurisoline inhibits glycolysis of lung cancer by targeting the AKT-HK2 axis

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