Food-Derived Bioactive Peptides on Inflammation and Oxidative Stress

Abstract

Chronic diseases such as atherosclerosis and cancer are now the leading causes of morbidity and mortality worldwide. Inflammatory processes and oxidative stress underlie the pathogenesis of these pathological conditions. Bioactive peptides derived from food proteins have been evaluated for various beneficial effects, including anti-inflammatory and antioxidant properties. In this review, we summarize the roles of various food-derived bioactive peptides in inflammation and oxidative stress and discuss the potential benefits and limitations of using these compounds against the burden of chronic diseases.

Characteristic of antioxidant activity of dry-cured pork loins inoculated with probiotic strains of LAB

“…As an example, proteins are a group of molecules affected by ROS (Sarmadi & Ismail, 2010). Cleavage of the peptide bond, amino acid modification and the formation of cross-linked peptide aggregates take place during protein oxidation by ROS, which leads to the formation of protein derivatives possessing highly reactive carbonyl groups (ketones and aldehydes) that are involved in complications in diabetes and in many age-related diseases (Chakrabarti, Jahandideh, & Wu, 2014;Stadtman & Levine, 2003). Living organisms are protected from the effects of oxidative stress by various defence systems.…”

“…The ability of these protective systems gradually decreases with age, resulting in a disruption of the normal redox balance. Intake of antioxidant compounds along with food helps to maintain the state of equilibrium of pro-oxidants/antioxidants in the body (Chakrabarti et al, 2014).…”

Analysis of in vitro antioxidant activity of Caryota urens L. leaves: A traditional natural remedy

“…Once an excess amount of free radicals is produced, they can reduce endogenous defensive enzymes and consequently generate deleterious cellular effects by oxidizing biomolecules like membrane lipids, cellular proteins, enzymes, DNA and RNA, later ending cellular respiration [42]. Numerous studies have revealed that antioxidants obtained from plant may be beneficial in preventing or slowing the destructive outcome of oxidative stress [43][44][45]. Herein, the antioxidant activity of CEE and its resulting fractions at several concentrations were tested.…”

Opioid peptides and gastrointestinal symptoms in autism spectrum disorders

“…10 Some bioactive peptides act directly on the gastrointestinal lumen, while others act on peripheral organs following absorption in the bowel, playing a role in reducing arterial blood pressure, modulating immune cells, and regulating nervous functions. 11 Factors involved in the absorption of these peptides include the inhibition of peptidases 12 and the permeability of the intestinal barrier. 13 Nevertheless, the opioid excess theory has been criticized due to the fact that no abnormal concentrations of opioid peptides had ever been detected in the plasma or in the CNS of individuals with ASD.…”