Food-derived Bioactive Peptides with Angiotensin-Converting Enzyme Inhibiting Effect: A Systematic Review

Abstract

Objective To describe the current scientific evidence of food-derived bioactive peptides and their angiotensin-converting enzyme inhibiting effect. Methods Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) were followed. We searched MEDLINE (through PubMed) and Science Direct databases to identify studies assessing food-derived bioactive peptides and angiotensin-converting enzyme-inhibiting effects. The evidence was organized and presented using tables and narrative synthesis. Results We identified 11 peptides with the best antihypertensive potential: RDGGYCC, LRLESF, FHAPWK, and LVLPG from plants; LSGYGP, ITT, VISDEDGVTH, ATT, and LWHTH from animals; and ALGRV and SPQW from fungi, which demonstrated their antihypertensive potential in vitro and in vivo. Conclusion Overall, food-derived bioactive peptides with hypertensive activity were identified, which shows a promising field as a therapeutic alternative to conventional pharmacological treatments.

The targeted development of collagen-active peptides based on composite enzyme hydrolysis: a study on the structure–activity relationship

“…39 Several authors attribute the antihypertensive effectiveness of peptides to their structure, which is generally reported to be of low molecular weight and short length. 40,41 Some scholars have explored the ACE-inhibitory activity of peptide fragments obtained from tomato processing by-products fermented using Bacillus subtilis and found that peptides with molecular weights ranging from 500 to 850 Da were very active in their ACE-inhibitory activity compared with those with molecular weights ranging from 850 to 3000 Da. 42 This may be because small peptides can easily enter ACE active sites.…”