Food Drug Interactions

Abstract

The effect of drug on a person may be different than expected because that drug interacts with another drug the person is taking (drug-drug interaction), food, beverages, dietary supplements the person is consuming (drug-nutrient/food interaction) or another disease the person has (drug-disease interaction). A drug interaction is a situation in which a substance affects the activity of a drug, i.e. the effects are increased or decreased, or they produce a new effect that neither produces on its own. These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances. Regarding food-drug interactions physicians and pharmacists recognize that some foods and drugs, when taken simultaneously, can alter the body's ability to utilize a particular food or drug, or cause serious side effects. Clinically significant drug interactions, which pose potential harm to the patient, may result from changes in pharmaceutical, pharmacokinetic, or pharmacodynamic properties. Some may be taken advantage of, to the benefit of patients, but more commonly drug interactions result in adverse drug events. Therefore it is advisable for patients to follow the physician and doctors instructions to obtain maximum benefits with least food-drug interactions. The literature survey was conducted by extracting data from different review and original articles on general or specific drug interactions with food. This review gives information about various interactions between different foods and drugs and will help physicians and pharmacists prescribe drugs cautiously with only suitable food supplement to get maximum benefit for the patient.

Knowledge of Food and Drug Interactions among Nurses: Assessment Strategy for Continuing Education

“…Warfarin interacts with many foods (Nutescu et al, 2011). Vegetables, such as broccoli, kale, spinach, rich in vitamin K, when consumed in large quantity, will interfere with the effectiveness and safety of warfarin (Bushra, 2011). FDI occur when the presence of a food changes the bioavailability of a drug co-administered together.…”

“…Food and Drug Interaction (FDI), an adverse drug reaction, is one of the sources of medication errors (Bushra et al, 2011). Adverse Drug Reactions (ADRs), pose a significant public health problem requiring solutions.…”

Interactions Between Food and Drugs

“…Skuteczność leczenia sprawdza się z użyciem wskaźnika INR (international normalized ratio) -jest to międzynarodowy znormalizowany współczynnik. Jeżeli jego wartość jest zbyt duża, pojawiają się powikłania krwotoczne, a w przypadku zaniżonego INR istnieje duże prawdopodobieństwo wystąpienia zakrzepicy [21]. Jeże-li dieta jest bogata w witaminę K, to do osiąg nięcia pożądanego INR są konieczne większe dawki warfaryny i odwrotnie -w czasie stosowania diety ubogiej w witaminę K można osiągnąć terapeutyczny INR, stosując mniejsze dawki tego leku [22].…”

“…Należy pamiętać, że ekspozycja olejów na światło przez 48 godz. powoduje zniszczenie zawartości filochinonu na poziomie 50, a nawet 95% [21].…”

“…W chwili rezygnacji z tego soku jego choroba zniknęła, najprawdopodobniej był to skutek zahamowania metabolizmu cilostazolu przez składniki obecne w soku [27].…”