Food for Special Medical Purposes and Nutraceuticals for Pain: A Narrative Review

Casale, Roberto; Symeonidou, Zaira; Ferfeli, Sofia; Micheli, Fabrizio; Scarsella, Paolo; Paladini, Antonella

doi:10.1007/s40122-021-00239-y

Cited by 17 publications

(19 citation statements)

References 112 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Glial cells produce palmitoylethanolamide (PEA) ( Scuderi et al, 2012 ), a lipid messenger that arises naturally as an amide of ethanolamide and palmitic acid ( Beggiato et al, 2020 ). PEA is thought to affect local cells, degranulation, and the creation of various inflammatory mediators such as neurotrophic factors (like nerve growth factor) and TNF-α ( Casale et al, 2021 , Lambert et al, 2002 , Skaper et al, 2015 ).…”

Section: Palmitoylethanolamidementioning

confidence: 99%

“…Palmitoylethanolamide (PEA), a natural compound from peanut meal, egg yolk, and soybean lecithin, is an analog of anandamide ( Casale et al, 2021 , Lambert et al, 2002 ). PEA, like other endogenous N-acylethanolamine compounds, is known to mimic several endocannabinoid-driven actions even though it does not bind to cannabinoid receptors.…”

Section: Introductionmentioning

confidence: 99%

“…PEA, like other endogenous N-acylethanolamine compounds, is known to mimic several endocannabinoid-driven actions even though it does not bind to cannabinoid receptors. As a result, PEA and other endogenous N-acylethanolamine compounds bind to the peroxisome proliferator-activated receptor (PPARα) expressed on neurons and astrocytes with a relatively high affinity ( Casale et al, 2021 , Scuderi et al, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Review of Alzheimer’s disease drugs and their relationship with neuron-glia interaction

Ajenikoko

Ajagbe

Onigbinde

et al. 2023

IBRO Neuroscience Reports

View full text Add to dashboard Cite

Section: Palmitoylethanolamidementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Review of Alzheimer’s disease drugs and their relationship with neuron-glia interaction

Ajenikoko

Ajagbe

Onigbinde

et al. 2023

IBRO Neuroscience Reports

View full text Add to dashboard Cite

“…Among all, eicosapentaenoic acid and docosahexaenoic acid are precursor of resolvines, inflammation mediators able to modulate pain stimulus and spinal cord plasticity. However, ω-3 are characterized by several roles such as anti-inflammatory, immunomodulatory and cardioprotective effects [ 148 ]. These properties make ω-3 a major actor in the diet supplementation approach, and this has been clinically confirmed.…”

Section: Nutritional Supplements In Neuropathic Painmentioning

confidence: 99%

The Influence of Dietary Supplementations on Neuropathic Pain

D’Egidio

Lombardozzi

M’Barek

et al. 2022

Life

View full text Add to dashboard Cite

Neuropathic pain is defined as pain caused by a lesion or disease of the somatosensory nervous system and affects 7–10% of the worldwide population. Neuropathic pain can be induced by the use of drugs, including taxanes, thus triggering chemotherapy-induced neuropathic pain or as consequence of metabolic disorders such as diabetes. Neuropathic pain is most often a chronic condition, and can be associated with anxiety and depression; thus, it negatively impacts quality of life. Several pharmacologic approaches exist; however, they can lead numerous adverse effects. From this perspective, the use of nutraceuticals and diet supplements can be helpful in relieve neuropathic pain and related symptoms. In this review, we discuss how diet can radically affect peripheral neuropathy, and we focus on the potential approaches to ameliorate this condition, such as the use of numerous nutritional supplements or probiotics.

show abstract

“…Invasive nonpharmacologic therapies for neuropathic pain include massage therapy, trigger point injections, acupuncture, transcutaneous electrical nerve stimulation (TENS), and motor cortex stimulation (MCS), with varying effects in the attenuation of this chronic pain condition. So-called "nutraceuticals" and other nonpharmaceutical supplements have gained significant attention in recent years and may serve to work in synergy with existing pharmaceutical-based treatment regimens for combatting chronic neuropathic pain [10,11]. Although the pharmaceutical industry has historically derived its drugs from natural products, nonpharmaceutical natural products and supplements are being increasingly evaluated, with significant advances in high-throughput screening capabilities for nonpharmaceutical natural compounds [12,13].…”

Section: Introductionmentioning

confidence: 99%

Nutritional Supplements for the Treatment of Neuropathic Pain

Abdelrahman

Hackshaw

2021

Biomedicines

View full text Add to dashboard Cite

Neuropathic pain affects 7–10% of the population and is often ineffectively and incompletely treated. Although the gold standard for treatment of neuropathic pain includes tricyclic antidepressants (TCAs), serotonin-noradrenaline reuptake inhibitors, and anticonvulsants, patients suffering from neuropathic pain are increasingly turning to nonpharmacologic treatments, including nutritional supplements for analgesia. So-called “nutraceuticals” have garnered significant interest among patients seeking to self-treat their neuropathic pain with readily available supplements. The supplements most often used by patients include vitamins such as vitamin B and vitamin D, trace minerals zinc and magnesium, and herbal remedies such as curcumin and St. John’s Wort. However, evidence surrounding the efficacy and mechanisms of these supplements in neuropathic pain is limited, and the scientific literature consists primarily of preclinical animal models, case studies, and small randomized controlled trials (RCTs). Further exploration into large randomized controlled trials is needed to fully inform patients and physicians on the utility of these supplements in neuropathic pain. In this review, we explore the basis behind using several nutritional supplements commonly used by patients with neuropathic pain seen in rheumatology clinics.

show abstract

Food for Special Medical Purposes and Nutraceuticals for Pain: A Narrative Review

Cited by 17 publications

References 112 publications

Review of Alzheimer’s disease drugs and their relationship with neuron-glia interaction

Review of Alzheimer’s disease drugs and their relationship with neuron-glia interaction

The Influence of Dietary Supplementations on Neuropathic Pain

Nutritional Supplements for the Treatment of Neuropathic Pain

Contact Info

Product

Resources

About