Food hypersensitivity is common in Swedish schoolchildren, especially oral reactions to fruit and gastrointestinal reactions to milk

Strinnholm, Åsa; Winberg, Anna; West, Christina; Hedman, Linnéa; Rönmark, Eva

doi:10.1111/apa.12772

Cited by 21 publications

(28 citation statements)

References 30 publications

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“…The cumulative incidence of reported food allergy or food intolerance in our study was at about the same level as in another Swedish study where 21% of children aged seven to eight years reported food allergy or food intolerance . Oral symptoms were the most frequently reported symptoms in their study, which contrasted with the low cumulative incidence of OAS in our study.…”

Section: Discussionsupporting

confidence: 69%

Allergic rhinoconjunctivitis continued to increase in Swedish children up to 2007, but asthma and eczema levelled off from 1991

et al. 2016

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Section: Discussionsupporting

confidence: 69%

Allergic rhinoconjunctivitis continued to increase in Swedish children up to 2007, but asthma and eczema levelled off from 1991

et al. 2016

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“…Endocrine influences have been suggested to contribute to this switch during adolescence [ 19 ]. In our cohort, reported FHS was more common among girls already at 8 years of age, mainly due to a higher female prevalence of FHS to cow´s milk [ 26 ]. This gender difference is in line with a recent Canadian study, where more women than men reported symptoms of lactose intolerance [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

High incidence and remission of reported food hypersensitivity in Swedish children followed from 8 to 12 years of age – a population based cohort study

Winberg¹,

Strinnholm²,

Hedman³

et al. 2014

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BackgroundFew population-based cohort studies have examined reported food hypersensitivity longitudinally. We investigated prevalence, incidence and remission of perceived food hypersensitivity among schoolchildren from 8 to 12 years of age, and risk factors associated with incidence and remission.MethodsA population-based cohort including all 7–8 year-old children in three Swedish towns was recruited in 2006. A total of 2,585 (96% of invited) children participated in a parental questionnaire. The children in two of the towns, n = 1,700 (90% of invited) also participated in skin-prick-testing with airborne allergens. The cohort was followed using the same methods at 11–12 years of age. At study follow up, specific IgE to foods was analyzed in a randomized subset of children (n = 652).ResultsThe prevalence of perceived food hypersensitivity increased from 21% at 8 years to 26% at 12 years of age. During this four-year-period, the cumulative incidence of food hypersensitivity was high (15%), as was remission (33%). This pattern was particularly evident for hypersensitivity to cow´s milk, while the incidence of hypersensitivity to other foods was lower. Female sex, allergic heredity, current rhinitis and allergic sensitization were associated with the incidence of food hypersensitivity and allergic sensitization was negatively associated with remission. Risk-factor-patterns for both incidence and remission were different for hypersensitivity to milk compared with hypersensitivity to other foods. Generally, the agreement between reported food hypersensitivity and IgE-sensitization to the implicated food was poor.ConclusionsIn this longitudinal, population-based cohort-study perceived food hypersensitivity was common among children between ages 8 and 12, often transient and not well correlated with food-specific IgE. While these findings suggest an overestimated prevalence of food hypersensitivity, the public-health-significance remains high as they reflect the perceived reality to which the children adapt their life and food intakes.Electronic supplementary materialThe online version of this article (doi:10.1186/2045-7022-4-32) contains supplementary material, which is available to authorized users.

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“…Family history of allergy [23–25] and allergic diseases in early life, particularly eczema [23] and Immunoglobulin E (IgE) reactivity [24–27], are established risk factors, whereas early life environmental factors and socio-demographic exposures remain incompletely understood [23, 25–30]. Less is known about the risk factors for, and the prognosis of FRS and FA from early life through adolescence.…”

Section: Introductionmentioning

confidence: 99%

Food-Related Symptoms and Food Allergy in Swedish Children from Early Life to Adolescence

et al. 2016

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BackgroundRisk factors for persistence of food-related symptoms (FRS) and food allergy (FA) from early life to adolescence are incompletely understood. The aim of this study was to identify risk factors for FRS and FA in adolescence amongst children with FRS or FA in the first four years of life (early life).MethodsIn children enrolled in a Swedish birth cohort and followed to 16 years (n = 2572), we defined children with early life FRS in the absence of FA, and FA. Corresponding phenotypes were defined at 16 years. Associations between potential risk factors at 4 years and FRS and FA at 16 years were investigated using logistic regression.ResultsEarly life FRS and FA prevalences were 12.2% and 6.8%, respectively. Amongst children with early life FRS, 35.7% had FRS or FA at 16 years, whereas 74.3% of the children with early life FA had FA at 16 years. For each of the early life phenotypes, parental allergy, early life allergic multimorbidity, early life reactions to peanuts/tree nuts and IgE reactivity at 4 years were statistically significantly associated with FRS or FA at 16 years. In contrast, male sex was associated with an increased risk of FA at 16 years among children with early life FA only.ConclusionsIn early life, food-related symptoms are twice as common as food allergy. Unlike food allergy, food-related symptoms often remit by adolescence. Yet, these phenotypes have many common risk factors for persistence to adolescence.

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Food hypersensitivity is common in Swedish schoolchildren, especially oral reactions to fruit and gastrointestinal reactions to milk

Cited by 21 publications

References 30 publications

Allergic rhinoconjunctivitis continued to increase in Swedish children up to 2007, but asthma and eczema levelled off from 1991

Allergic rhinoconjunctivitis continued to increase in Swedish children up to 2007, but asthma and eczema levelled off from 1991

High incidence and remission of reported food hypersensitivity in Swedish children followed from 8 to 12 years of age – a population based cohort study

Food-Related Symptoms and Food Allergy in Swedish Children from Early Life to Adolescence

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