Food-induced IgA Vasculitis (Henoch-Schönlein Purpura)

Díaz, Javier Moreno; González, A.; Alonso, Rosa Eva Bautista; Bruñén, Jose Miguel García; Repiso, Gonzalo Acebes

doi:10.12890/2017_000774

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…The pathophysiological process of HSPN is unknown, but some scholars have proposed that genetic factors, environment and immune abnormalities have led to the occurrence and development of HSPN [ 5 ]. Allergies caused by food, infections, drugs and/or other allergens may be also associated with HSPN [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Intestinal dysbiosis featuring abundance of Streptococcus associates with Henoch-Schönlein purpura nephritis (IgA vasculitis with nephritis) in adult

et al. 2022

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Background The pathogenesis of Henoch-Schönlein purpura nephritis (HSPN) is closely associated with mucosal infection. But whether intestinal microbiota dysbiosis plays a role in it is not clear. Methods A total of 52 participants including 26 HSPN patients and 26 healthy controls were included. By using 16S ribosomal RNA gene sequencing, the intestinal microbiota composition between HSPN and healthy controls was compared. The diagnostic potency was evaluated by Receiver operating characteristic (ROC) with area under curves (AUC). Meanwhile, correlation analysis was also performed. Results The lower community richness and diversity of fecal microbiota was displayed in HSPN patients and the structure of gut microbiota was remarkedly different. A genus-level comparison indicated a significant increase in the proportions of g-Bacteroides, g-Escherichia–Shigella and g-Streptococcus, and a marked reduction of g-Prevotella_9 in HSPN patients, suggesting that the overrepresentation of potential pathogens and reduction of profitable strains were the main feature of the dysbiosis. The differential taxonomic abundance might make sense for distinguishing HSPN from healthy controls, with AUC of 0.86. The relative abundance of the differential bacteria was also concerned with clinical indices. Among them, Streptococcus spp. was positively associated with the severity of HSPN (P < 0.050). It was found that HSPN patients with higher level of Streptococcus spp. were more likely to suffering from hematuria and hypoalbuminemia (P < 0.050). Conclusions The dysbiosis of gut microbiota was obvious in HSPN patients, and the intestinal mucosal streptococcal infection was distinctive, which was closely related to its severity.

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Section: Introductionmentioning

confidence: 99%

Intestinal dysbiosis featuring abundance of Streptococcus associates with Henoch-Schönlein purpura nephritis (IgA vasculitis with nephritis) in adult

et al. 2022

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“…The management of IgAV starts with a detailed history taking, physical examination, and relevant investigation, including biopsy of the primary involved organ [12]. Different immunosuppressants such as corticosteroids, cyclophosphamide, azathioprine, and rituximab are effective in the treatment of IgAV [5,13].…”

Section: Discussionmentioning

confidence: 99%

An Unusual Clinical Presentation of Immunoglobulin A Vasculitis in an Elderly Patient

Anokwute¹,

Bakare²,

Ogbuji³

et al. 2020

Cureus

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Immunoglobulin A (IgA) vasculitis (IgAV), also known as Henoch-Schonlein purpura, is an IgA-mediated leukocytoclastic vasculitis predominantly affecting the gastrointestinal tract, kidneys, and skin. IgAV appears to be more common in children and is relatively rare in the adult population. We describe a case of a 72-year-old man who presented with bilateral lower extremity swelling, nausea, vomiting, abdominal pain, and weight loss, in which a diagnosis of IgAVs was established with a skin biopsy. This case highlights a rare and unusual clinical presentation of IgAV in an older patient and the need for prompt diagnosis and treatment.

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Een vrouw van middelbare leeftijd met recidiverende diarreeklachten sinds jaren

Timmermans¹,

Nachtergaele²,

Bogaert³

2022

Tijdschr Geneesk

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A middle-aged woman with recurrent diarrhoea since years The case of a 49-year-old woman with abdominal discomfort since years, presenting with bloody diarrhoea and the recent development of joint pain and petechiae, is described. Laboratory analysis showed slightly elevated inflammatory parameters, as well as an elevated IgA level. Urinalysis showed microscopic haematuria and a significant proteinuria of 2.61 g/L, suspecting a glomerular pathology. The further investigation with autoimmune serology and protein electrophoresis was negative. A colonoscopy and kidney biopsy were performed. The colonoscopy demonstrated vasculitis at the terminal ileum. On the kidney biopsy, immunofluorescence showed IgA deposition in the mesangium, endocapillary injury and crescent formation, proving the diagnosis of IgA vasculitis complicated with renal involvement. IgA vasculitis, also known as Henoch-Schönlein purpura, is a systemic leukocytoclastic vasculitis affecting the small blood vessels. It is a typical childhood disease; almost 90% of the patients are children. The pathogenesis of the disease remains mainly unknown. The IgA level is raised, probably provoked by the presentation of an antigen to the mucosa-associated lymphoid tissue. Renal damage in adults is more frequent and severe, and therefore connected to morbidity.

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Food-induced IgA Vasculitis (Henoch-Schönlein Purpura)

Cited by 3 publications

References 7 publications

Intestinal dysbiosis featuring abundance of Streptococcus associates with Henoch-Schönlein purpura nephritis (IgA vasculitis with nephritis) in adult

Intestinal dysbiosis featuring abundance of Streptococcus associates with Henoch-Schönlein purpura nephritis (IgA vasculitis with nephritis) in adult

An Unusual Clinical Presentation of Immunoglobulin A Vasculitis in an Elderly Patient

Een vrouw van middelbare leeftijd met recidiverende diarreeklachten sinds jaren

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