Food intake and preference of olfactory bulbectomized rats fed amino acid imbalanced or deficient diets

Chemical signals from conspecfics modify the activity of female bank voles Clethrionomys glareolus

“…The vomeronasal system has been shown to be especially important for the perception of chemicals involved in reproductive processes (Wysocki 1979, Meredith 1991, whereas the main olfactory system appears to be responsible for food detection (Leung et al 1972) and individual recognition (Gheusi et al 1994). However, the function of these two systems sometimes overlaps (reviewed in Pfeiffer and Johnston 1994).…”

“…The bulbectomy was performed according to the technique of Leung et al (1972). The females were placed in a stereotaxic apparatus, a cranial midline incision was made, and after the overlying cranial vault was removed the olfactory bulbs were removed by aspiration.…”

Hypothalamic signaling in anorexia induced by indispensable amino acid deficiency

“…IAA deficiency-induced anorexia (IAADA) is mediated by the central nervous system and is not dependent upon olfaction, taste, or other peripheral sensory systems (25). IAADA necessitates the detection of the IAA deficiency, transduction of the signal, and activation of neural circuits that control feeding behavior (15,16,26,33).…”

Circadian feeding entrains anticipatory metabolic activity in piriform cortex and olfactory tubercle, but not in suprachiasmatic nucleus

“…Second, the role of APCx as a chemosensor does not depend on the olfactory bulb. Behaviorally, bulbectomized rats show similar food intake and dietary selection behavior as intact rats (Leung et al 1972). Further studies are necessary to clarify the physiological relevance of metabolically entrained APCx and OTu in food entrainment.…”