Food intake biomarkers for apple, pear, and stone fruit

Ulaszewska, Marynka; Vázquez-Manjarrez, Natalia; Garcia-Aloy, Mar; Llorach, Rafaël; Mattivi, Fulvio; Dragsted, Lars Ove; Praticò, Giulia; Manach, Claudine

doi:10.1186/s12263-018-0620-8

Cited by 59 publications

(35 citation statements)

References 95 publications

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“…Coumarins are lactones derived from hydroxycinnamic acids, a flavonoid, [ 37,38 ] , which are well‐documented in many plant‐based foods including apples. [ 39,40 ] A previous study reported that plasma concentrations of hydroxycinnamic acids (including phloretin and coumaric acid) significantly increased after consumption of 1 kg of apple, peaking between 1–3 h following apple consumption, in a short‐term intervention study. [ 40 ] In this study, the urinary levels of 2,6‐dimethyl‐2‐(2‐hydroxyethyl)‐3,4‐dihydro‐2H‐1‐benzopyran peaked at 4 h following apple consumption.…”

Section: Discussionmentioning

confidence: 99%

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Metabolomic‐Based Approach to Identify Biomarkers of Apple Intake

McNamara

Collins

Harsha

et al. 2020

Molecular Nutrition Food Res

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Scope There is an increased interest in developing biomarkers of food intake to address some of the limitations associated with self‐reported data. The objective is to identify biomarkers of apple intake, examine dose–response relationships, and agreement with self‐reported data. Methods and results Metabolomic data from three studies are examined: an acute intervention, a short‐term intervention, and a free‐living cohort study. Fasting and postprandial urine samples are collected for analysis by 1H‐NMR and liquid chromatography–mass spectrometry (LC–MS). Calibration curves are developed to determine apple intake and classify individuals into categories of intake. Multivariate analysis of data reveals that levels of multiple metabolites increase significantly post‐apple consumption, compared to the control food—broccoli. In the dose‐response study, urinary xylose, epicatechin sulfate, and 2,6‐dimethyl‐2‐(2‐hydroxyethyl)‐3,4‐dihydro‐2H‐1‐benzopyran increase as apple intake increases. Urinary xylose concentrations in a free‐living cohort perform poorly at an individual level but are capable of ranking individuals in categories of intake. Conclusion Urinary xylose exhibits a dose–response relationship with apple intake and performs well as a ranking biomarker in the population study. Other potential biomarkers are identified and future work will combine these with xylose in a biomarker panel which may allow for a more objective determination of individual intake.

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Section: Discussionmentioning

confidence: 99%

“…Epicatechin sulfate is the sulfate form of epicatechin, a flavonoid, which has multiple plant sources. [ 31,39 ] Methyl(epi)catechin sulfate has previously been associated with apple and pear intake. [ 31 ] When comparing urinary metabolome profiles with data from a 24‐h dietary recall, Edmands et al.…”

Section: Discussionmentioning

confidence: 99%

Metabolomic‐Based Approach to Identify Biomarkers of Apple Intake

McNamara

Collins

Harsha

et al. 2020

Molecular Nutrition Food Res

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“…This work aimed to provide an overview of the metabolites found in biological fluids that could potentially act as BFIs for grape and different berry types, further evaluating their validity considering the current available information and identifying the aspects that require further investigation. There are several examples where a single metabolite could be a biomarker of a particular food intake, such as phloretin for apple intake [ 166 ]. However, the composition of each plant food is very complex (from the quantitative and qualitative point of view) and many of the compounds are widely distributed among a variety of foods [ 62 ].…”

Section: Introductionmentioning

confidence: 99%

Food intake biomarkers for berries and grapes

et al. 2020

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Grapes and berries are two types of widely consumed fruits characterized by a high content in different phytochemicals. However, their accurate dietary assessment is particularly arduous, because of the already wide recognized bias associated with self-reporting methods, combined with the large range of species and cultivars and the fact that these fruits are popularly consumed not only in fresh and frozen forms but also as processed and derived products, including dried and canned fruits, beverages, jams, and jellies. Reporting precise type and/or quantity of grape and berries in FFQ or diaries can obviously be affected by errors. Recently, biomarkers of food intake (BFIs) rose as a promising tool to provide accurate information indicating consumption of certain food items. Protocols for performing systematic reviews in this field, as well as for assessing the validity of candidate BFIs have been developed within the Food Biomarker Alliance (FoodBAll) Project. This paper aims to evaluate the putative BIFs for blueberries, strawberries, raspberries, blackberries, cranberries, blackcurrant, and grapes. Candidate BFIs for grapes were resveratrol metabolites and tartaric acid. The metabolites considered as putative BFI for berries consumption were mostly anthocyanins derivatives together with several metabolites of ellagitannins and some aroma compounds. However, identification of BFIs for single berry types encountered more difficulties. In the absence of highly specific metabolites reported to date, we suggested some multi-metabolite panels that may be further investigated as putative biomarkers for some berry fruits.

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“…To facilitate the identification and evaluation of new candidate BFIs, the Food Biomarker Alliance (FoodBAll) [21], a project funded by the Joint Programming Initiative a Healthy Diet for a Healthy Life, established guidelines to conduct a literature search dedicated to food intake biomarkers [25] and to evaluate their level of validation using a set of consensus criteria [26]. The guidelines were applied for all major food groups: fruit and vegetables, meats, fish, and other marine foods, dairy products, cereals and whole grains, alcoholic and non-alcoholic beverages, vegetable oils, nuts, and spices and herbs (http://foodmetabolome.org/wp3) [27][28][29][30][31][32][33][34][35][36]. The present article presents the results of the in depth exploration of possible biomarkers of intake for green leafy vegetables (lettuce, spinach, endive, and garden rocket) as well as bulb and stem vegetables (artichoke, asparagus, celery).…”

Section: Introductionmentioning

confidence: 99%

Food intake biomarkers for green leafy vegetables, bulb vegetables, and stem vegetables: a review

et al. 2020

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Background: Numerous studies acknowledged the importance of an adequate vegetable consumption for human health. However, current methods to estimate vegetable intake are often prone to measurement errors due to self-reporting and/or insufficient detail. More objective intake biomarkers for vegetables, using biological specimens, are preferred. The only concentration biomarkers currently available are blood carotenoids and vitamin C, covering total fruit and vegetable intake. Identification of biomarkers for specific vegetables is needed for a better understanding of their relative importance for human health. Within the FoodBAll Project under the Joint Programming Initiative "A Healthy Diet for a Healthy Life", an ambitious action was undertaken to identify candidate intake biomarkers for all major food groups consumed in Europe by systematically reviewing the existent literature. This study describes the review on candidate biomarkers of food intake (BFIs) for leafy, bulb, and stem vegetables, which was conducted within PubMed, Scopus and Web of Science for studies published through March 2019. Results: In total, 65 full-text articles were assessed for eligibility for leafy vegetables, and 6 full-text articles were screened for bulb and stem vegetables. Putative BFIs were identified for spinach, lettuce, endive, asparagus, artichoke, and celery, but not for rocket salad. However, after critical evaluation through a validation scheme developed by the FoodBAll consortium, none of the putative biomarkers appeared to be a promising BFI. The food chemistry data indicate that some candidate BFIs may be revealed by further studies. Conclusion: Future randomized controlled feeding studies combined with observational studies, applying a nontargeted metabolomics approach, are needed in order to identify valuable BFIs for the intake of leafy, bulb, and stem vegetables.

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Food intake biomarkers for apple, pear, and stone fruit

Cited by 59 publications

References 95 publications

Metabolomic‐Based Approach to Identify Biomarkers of Apple Intake

Metabolomic‐Based Approach to Identify Biomarkers of Apple Intake

Food intake biomarkers for berries and grapes

Food intake biomarkers for green leafy vegetables, bulb vegetables, and stem vegetables: a review

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