Food Intake Depression and Other Metabolic Effects of Tannic Acid in the Rat

Glick, Z.; Joslyn, M. A.

doi:10.1093/jn/100.5.509

Cited by 100 publications

(40 citation statements)

References 20 publications

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“…Frutos (2004) reported that consumption of plant species such as Garcinia kola containing tannin (generally > 50g/kg -1 of DM) significantly reduced voluntary food intake in ruminants while medium or low consumption (> 50g/kg) seem not to affect it. Glick and Joslyn (1970) had earlier reported the food intake depression and subsequent decrease in weight of rats fed tannic acid. The decrease in food intake and weight loss in rabbits fed on diets with G. kola inclusion may therefore be associated with tannin content of G. kola.…”

Section: Effect Of Dietary Treatment On the Performance Of Rabbitsmentioning

confidence: 94%

Performance and Haematological Parameters of Rabbits fed graded levels of Bitter kola (Garcinia kola)

Ebenebe¹,

Nwankwor²,

Izukanne³

et al. 2016

Int. J. Livest. Prod.

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The need to reduce cost of production of meat animal has necessitated the use of plant materials with medicinal properties as feed additives capable of minimizing the influence of pathogenic microbes and improving performance of the animal. This study investigated the effect of such medicinal plant materials Garcinia kola on the growth performance and the haematological parameters of 20 weeks old rabbits. Thirty six rabbits of mixed breed and mixed sexed were used for the experiment, which lasted for eight weeks (56 days). The rabbits were randomly assigned to four dietary treatments: T 1 with no (0%), T 2 (2.5%), T 3 (5%) and T 4 (7.5%) of G. kola inclusion. The rabbits were housed in 2m × 1m × 1m cages per three rabbits in a 4 × 3 CRD experimental design whereby each treatment had three replicates, with each replicate having 4 rabbits and each treatment comprised 12 rabbits. During the eight week period of the experiment, feed and water were given ad libtum and while similar managerial and sanitary measures were applied for all the animals. Daily feed intake and growth performance of animals in each unit were monitored. At the beginning and the end of the experiment, blood samples were collected from the ear and analyzed for haematological parameters Hb, PCV, RBC, WBC and Plasma proteins). The result showed that G. kola has significant effect on the feed intake, growth rate, haemoglobin, PCV, RBC, WBC and Plasma protein. The feed intake decreased in all rabbits on G. kola treated feeds; numerical values obtained were 332 ± 0.32, 285 ± 0.52, 288 ± 0.12 and 262 ± 0.33 g/week for treatment 1, 2, 3, 4 respectively. Weight depression was also observed similarly in all the rabbits on Garcinia treated feeds with T2 having weight loss of 0.36 ± 0.11, T30.35 ± 0.12 and T4 0.64 ± 0.10kg. Rabbits on Garcinia treated feeds also have lower Hb, PCV, Plasma proteins and higher WBC and RBC compared to the initial values showing G. kola. G. kola appear to contain substances which depress feed intake and growth performance and the effect seem to increase with higher concentration. However, the RBC and WBC increased, it is therefore recommended that the use of G. kola should be at low levels of inclusion or intermittently not continuous.Key words: Garcinia kola, growth performance, rabbits. INTRODUCTIONTraditional animal healthcare practices involving use of some materials and herbal preparations called ethnoveterinary medicine is fast gaining grounds in the livestock industry especially in African and Asian countries (Ebenebe et al., 2010; Ojelade, 2015) as they provide readily available and low cost alternative to orthodox medicine. Of the herbal drug, the use of garlic (Allium sativum), ginger (Zingiber officinale), neem tree leaves (Azadiractha indica) and most recently bitter kola (Garcinia kola) have been reported in livestock health care management (Ebenebe et al., 2010; Esonu 2006, Owen and Amakiri 2013and Obun et al., 2013. Garcinia kola is a dicotyledonous belonging to the family Guttiferae or Clusiaceae and is widely...

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Section: Effect Of Dietary Treatment On the Performance Of Rabbitsmentioning

confidence: 94%

Performance and Haematological Parameters of Rabbits fed graded levels of Bitter kola (Garcinia kola)

Ebenebe¹,

Nwankwor²,

Izukanne³

et al. 2016

Int. J. Livest. Prod.

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“…They are also found to increase excretion of proteins and essential amino acids [51]. Mineral element overdose may also cause toxicity but this was not the case with the measured minerals since their levels were below the recommended daily allowance.…”

Section: Discussionmentioning

confidence: 89%

Blood Glucose Lowering Effect and Safety of the Aqueous Leaf Extracts of Zanha africana

KK¹,

DS²,

PK³

2015

Pharm Anal Acta

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Zanha africana has been used traditionally to manage many diseases including diabetes, however, its antidiabetic activity and safety is not well evaluated. The aim of this study was to determine in vivo hypoglycemic activity and safety of the aqueous leaf extracts of this plant in male Swiss white albino mice. The antidiabetic activity was screened in alloxan induced diabetic mice using oral and intraperitoneal routes. The safety of the extract was studied in mice that were orally and intraperitoneally administered with 1 g/kg body weight daily for 28 days by recording changes in body and organ weights, hematological and biochemical parameters. Mineral composition was estimated using total reflection X-ray fluorescence system and atomic absorption spectrometry. Phytochemical composition was assessed using standard procedures. The extract showed hypoglycemic activity at dose levels of 50, 100, 200, 300 mg/kg body weight. Administration of 1 g/kg body weight of the extract decreased the body weight gain using both routes. Intraperitoneal administration of the same dose increased the organ to body weight percentages of liver, brain and kidney, and elevated white blood cell count, lymphocyte count, and levels of γ-glutamyl transpeptidase, total bilirubin and direct bilirubin and deceased levels of aspartate aminotransferase and creatinine. Increase in levels of mean corpuscular hemoglobin, γ-glutamyl transpeptidase, lactate dehydrogenase and creatine kinase, and decrease in levels of platelets, alanine transaminase, aspartate aminotransferase, urea, creatinine, total bilirubin and direct bilirubin was recorded in mice orally administered with 1 g/kg body weight of the extract. The extract contained tannins, phenols, flavonoids, saponins, and alkaloids. Sodium, Chlorine, Potassium, Calcium, Titanium, Vanadium, Chromium, Manganese, Iron, Copper, Zinc, Arsenic, Cadmium, Magnesium, Nickel and Lead were present in the extracts at levels below the recommended daily allowance. The observed hypoglycemic activity and slight toxicity could be associated with the phytochemicals and mineral/ trace elements present in this extract.

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“…2, no such improvements in performance were noticed in pigs fed diets added with TA or TA in combination with antibiotics, in spite of lower diarrhea incidence in pigs fed An, TA, and AnTA diets. Previous researchers have reported TA to reduce growth performance in rats (Glick and Joslyn, 1970) and chicks (Kubena et al, 2001). Tannins are known to have a bitter or astringent taste which reduces palatability and hence feed intake (Jansman, 1993).…”

Section: Discussionmentioning

confidence: 92%

Effects of Tannic Acid Added to Diets Containing Low Level of Iron on Performance, Blood Hematology, Iron Status and Fecal Microflora in Weanling Pigs

Lee¹,

Shinde²,

Choi³

et al. 2009

Journal of Animal Science and Technology

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This study investigated the effects of tannic acid (TA) in the diets for weanling pigs prepared with/without supplemental Fe on performance, hematology, fecal microflora and diarrhea incidence. Limestone and calcium phosphate used in Experiment 1 and 2 were of semi-synthetic and feed-grade quality, respectively; while the trace-mineral premix used in both the experiments was prepared without any added Fe source. In Experiment 1, 108 weaned pigs (Landrace × Yorkshire × Duroc, initially 6.46 ± 1.04 kg BW) were allotted to 3 treatments including control (diet added with FeSO4 and antibiotic), T1 (diet devoid of FeSO4 and antibiotic) and T2 (T1 diet added with 125 mg/kg TA). Each treatment had 4 replicates with 9 pigs in each pen. Feeding of T1 diet had a negative effect on the performance and plasma Fe status of pigs, while addition of TA to T1 diet resulted in performance of pigs comparable to pigs fed the control diet, reduced diarrhea incidence but had a negative influence on the hematological and plasma Fe indices. Additionally, pigs fed T2 diet had fewer (p<0.05) total anaerobic bacteria, Clostridium spp. and coliforms than pigs fed T1 diet, and greater number of Bifidobacterium spp. and Lactobacillus spp. in feces when compared with pigs fed control and T1 diets. In Experiment 2, 144 weaned pigs (Landrace × Yorkshire × Duroc, initially 6.00 ± 1.07 kg BW) were allotted to 4 dietary treatments including control (diet added with FeSO4 and antibiotic) and diets devoid of supplemental Fe added with antibiotic (An), TA and both (AnTA). Each treatment had 4 replicates with 9 pigs in each pen. Addition of An, TA or both to diets devoid of supplemental Fe did not have any effect on performance, blood hematology and plasma Fe but resulted in reduced (p<0.05) diarrhea incidence and lower (p<0.05) fecal coliform population than pigs fed the control diet. These results suggest that TA has a negative influence on blood hematology and plasma Fe status when diets are inadequate in Fe; however, TA reduced diarrhea incidence and might have antimicrobial activity.

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Food Intake Depression and Other Metabolic Effects of Tannic Acid in the Rat

Cited by 100 publications

References 20 publications

Performance and Haematological Parameters of Rabbits fed graded levels of Bitter kola (Garcinia kola)

Performance and Haematological Parameters of Rabbits fed graded levels of Bitter kola (Garcinia kola)

Blood Glucose Lowering Effect and Safety of the Aqueous Leaf Extracts of Zanha africana

Effects of Tannic Acid Added to Diets Containing Low Level of Iron on Performance, Blood Hematology, Iron Status and Fecal Microflora in Weanling Pigs

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