Food intake regulation by diet-induced thermogenesis

Rampone, Alfred J.; Reynolds, Patrick

doi:10.1016/0306-9877(91)90057-6

Cited by 5 publications

(18 citation statements)

References 17 publications

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“…18 F-FDG uptake in the posterior neck was initially reported in 1996 (1). However, it was only after the introduction of PET/CT fusion technology that this focal uptake was recognized to be not in muscle but in fat-likely BAT (2,3).…”

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confidence: 99%

“…However, it was only after the introduction of PET/CT fusion technology that this focal uptake was recognized to be not in muscle but in fat-likely BAT (2,3). 18 F-FDG uptake in BAT may sometimes be indistinguishable from uptake in tumors or lymph nodes. Tumor or metastatic lymph node 18 F-FDG uptake may be masked by high 18 F-FDG uptake in BAT, leading to false-negative interpretations and possibly incorrect patient management.…”

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confidence: 99%

“…18 F-FDG uptake in BAT may sometimes be indistinguishable from uptake in tumors or lymph nodes. Tumor or metastatic lymph node 18 F-FDG uptake may be masked by high 18 F-FDG uptake in BAT, leading to false-negative interpretations and possibly incorrect patient management. Castelluci et al reported that 18 F-FDG uptake in BAT is the most common nontumoral site of focal intense uptake seen in follow-up studies of patients treated for lymphoma (4).…”

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confidence: 99%

“…Tumor or metastatic lymph node 18 F-FDG uptake may be masked by high 18 F-FDG uptake in BAT, leading to false-negative interpretations and possibly incorrect patient management. Castelluci et al reported that 18 F-FDG uptake in BAT is the most common nontumoral site of focal intense uptake seen in follow-up studies of patients treated for lymphoma (4). Increased uptake in the supraclavicular region has been reported to occur in 2.5%-4.0% of patients undergoing 18 F-FDG PET/CT studies (3).…”

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confidence: 99%

“…Castelluci et al reported that 18 F-FDG uptake in BAT is the most common nontumoral site of focal intense uptake seen in follow-up studies of patients treated for lymphoma (4). Increased uptake in the supraclavicular region has been reported to occur in 2.5%-4.0% of patients undergoing 18 F-FDG PET/CT studies (3). It is more common in women and is likely more common in winter (2,3).…”

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confidence: 99%

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Effect of Nicotine and Ephedrine on the Accumulation of 18F-FDG in Brown Adipose Tissue

Baba

Tatsumi

Ishimori

et al. 2007

Journal of Nuclear Medicine

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This study evaluated the effect of various b-adrenergic agonists on 18 F-FDG uptake in brown adipose tissue (BAT) in rats using ex vivo biodistribution studies. Methods: Caffeine (10 mg/kg of body weight, n 5 4), ephedrine (5 mg/kg of body weight, n 5 4), nicotine (0.8 mg/kg of body weight, n 5 9), or a mixture of nicotine and ephedrine (0.8 mg/kg of body weight and 5 mg/kg of body weight, respectively, n 5 9) was injected into the peritoneal cavity of female Lewis rats 30 min before intravenous 18 F-FDG injection. One hour after injection of 18 F-FDG, the animals were sacrificed, and BAT, other major organs, and blood were extracted. The biodistribution results were compared with body temperature data. Results: In the rats injected with nicotine or ephedrine, the mean uptake of 18 F-FDG, in percentage injected dose (%ID)/(g of interscapular BAT) · (kg of body weight), was significantly increased (7.9-fold for nicotine and 3.7-fold for ephedrine), compared to the control rats. Nicotine had the strongest effect on 18 F-FDG uptake in BAT. Caffeine increased BAT uptake slightly, but this increase did not reach statistical significance. The combination of nicotine and ephedrine increased the uptake 12.0-fold, compared with control rats; more than either nicotine or ephedrine alone. Uptake of 18 F-FDG in most other major organs did not change significantly. The effect of nicotine was blocked by prior injection of b-adrenergic antagonists. A transient decrease in body temperature was observed in the nicotine-injected group, and this effect was canceled by prior injection of b-adrenergic antagonists. No significant change in baseline temperature was seen before or after b-adrenergic agonist injection. Conclusion: Nicotine caused a greater increase in 18 F-FDG uptake in BAT than did other interventions, and the effect was increased when nicotine was combined with ephedrine. The effect of nicotine was completely blocked by prior injection of b-adrenergic antagonists, indicating that b-adrenergic agonists increase the metabolism of BAT. These preclinical data suggest that patients should avoid nicotine and ephedrine before undergoing 18 F-FDG PET to minimize 18 F-FDG uptake in BAT.

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confidence: 99%