PurposeFood waste is generated along the entire agricultural supply chain. From farm overproduction to lack of cold chain infrastructure, waste occurs for multiple reasons and negatively impacts the environment and society while generating economic losses. Although various supply chain actors and institutions have made attempts to reduce it, the activity is often confined to a single farm or to a retailer and charity dyad, without a systematic resolution of the problem. The environment is not only negatively impacted by the reduction of soil, water and biodiversity but also human beings suffer from malnutrition and food insecurity and finally, the entire supply chain faces considerable economic losses. Various supply chain actors have attempted to reduce this waste, but the results are often limited. The purpose of this paper is to consider systematic resolution by proposing a reconceptualisation from an alternative Operations and Supply Chain Management (O&SCM) perspective.Design/methodology/approachThe proposed paper is problem-based research, which merges the research and industry perspectives derived from the authors’ field experience interviewing different supply chain stakeholders in Italy, the UK, the USA and France with an analysis of O&SCM literature related to food loss and waste.FindingsIn order to address the food waste problem, we propose a new perspective in dealing with food loss and waste through the lens of O&SCM. By reconceptualising O&SCM theories and methods with the unique aspects of food loss and waste and taking into account the multitude of stakeholders involved, we propose five research avenues.Originality/valueThe perspective of O&SCM management is missing when dealing systematically with food loss and waste, as researchers neglect its unique characteristics.