Food Nanoemulsions: Stability, Benefits and Applications

Dasgupta, Nandita; Ranjan, Shivendu

doi:10.1007/978-981-10-6986-4_2

Cited by 9 publications

(4 citation statements)

References 149 publications

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“…Additionally, it can protect against oxidation and hydrolysis, thus improving the stability of chemically unstable active ingredients like astaxanthin. 8,25,26 One influential factor in nanoemulsion formation is the choice of surfactant type and concentration. Selecting the right surfactant is crucial to ensure safety (avoiding irritation) and to ensure that the amount of surfactant used in the formulation is sufficient to stabilise the nanoemulsion droplets.…”

Section: Resultszandydiscussionmentioning

confidence: 99%

https://tjnpr.org/index.php/home/article/view/3186

2023

TJNPR

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Astaxanthin is a xanthophyll carotenoid with antioxidant activity. The topical application of astaxanthin can enhance collagen density. However, its penetration into the skin is limited. Therefore, a delivery system, such as nanoemulsion, is needed. One factor influencing nanoemulsion formation is the selection of the type and concentration of surfactant. This study aims to determine the influence of surfactant combinations: Tween 80-Span 20 (F1), Tween 80-Span 60 (F2), and Tween 80-Span 80 (F3) in HLB system 14 on the characteristics, stability, irritability, and effectivity of astaxanthin nanoemulsion as an anti-ageing cosmetic. The nanoemulsion was prepared using the phase inversion composition (PIC) method. The pH values for all three formulas were within the range of normal skin pH (4-6), viscosity followed the order F1F2>F1, interfacial tension F1F1>F2. The characteristics of all three formulas meet the criteria for nanoemulsions with droplet sizes below 50 nm and polydispersity index (PDI) below 0.2 and without skin irritation. The Astaxanthin nanoemulsion with Tween 80-Span 80 (F3) surfactant combination was the most stable with better effects. Therefore, it has the potential for further formulation into anti-ageing cosmetic preparations.

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Section: Resultszandydiscussionmentioning

confidence: 99%

https://tjnpr.org/index.php/home/article/view/3186

2023

TJNPR

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“…Briefly, 2 mL of nanoemulsion was added to 500 mL of 0.1N HCl, and the experiment was conducted at 50 rpm and 37±0.5°C, and the Formulation was kept under visual inspection for the appearance of precipitation if any. 20,28…”

Section: Dispersibility Studymentioning

confidence: 99%

“…The morphology and size of Globules were investigated by employing SEM. 19,20,28 The investigation was performed by keeping the optimized lyophilized NIMO nanoemulsion on a metal plate and dried under a vacuum to form a dry film, followed by observation under SEM.…”

Section: Scanning Electron Microscopy (Sem)mentioning

confidence: 99%

“…kV/40 mA), 2-theta range 2-40°, with step size 0.02° 2θ and time per step 300 sec. 12,28,36 Entrapment Efficiency (EE): Entrapment Efficiency of fabricated NIMO nanoemulsion was determined by taking 5 mL of nanoemulsion in a 5 mL centrifuge tube and placed in a cooling centrifuge, and subjected to centrifugation at 20.000 rpm for 0.5 hr. The supernatant was collected and analyzed by using a UV spectrophotometer at 351nm, and the EE efficiency was calculated using the following formula…”

Section: Powder X-rd Studymentioning

confidence: 99%

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Design Expert-Implemented Nimodipine-Loaded Lyophilized Nanoemulsifying Drug Delivery System for Improved Oral Bioavailability and Physical Stability

Das,

Panda,

Jena

et al. 2024

Ind. J. Pharm. Edu. Res

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To improve the oral bioavailability as well as the physical stability of nimodipine, Design-Expert-driven nimodipine loaded nanoemulsifying drug delivery system was developed with a certain quality target product profile. Materials and Methods: In this investigation, the three components triacetin as oil phase, labrasol as a surfactant, and plurol oleique CC 497 as co-surfactant were selected after screening. The ratio of surfactant and co-surfactant (S mix ) was selected from the pseudo-ternary phase diagram drawn by using ProSim ternary software. A d-optimal mixture design was employed to optimize the formulation. The dynamic light scattering, Fourier transform Infrared, Differential Scanning Calorimetry, X-ray Diffraction, Scanning Electron Microscopy, in vitro drug release, stability study, and in vivo pharmacokinetic studies were carried out for the characterization of the optimized formulation. Results: The globule size, PDI, and Zeta potential of the optimized formulation were found to be 322.1 nm, 0.48, and -14.5 mV respectively. The result of in vivo pharmacokinetic studies exhibited three-fold enhanced oral bioavailability of the optimized nanoemulsion as compared to the pure drug of nimodipine and the physical stability of the optimized nanoemulsion improved significantly as compared to the pure drug. Conclusion: The NIMO-loaded nanoemulsifying drug delivery system can be successfully fabricated by implementing the Design-Expert with improved oral bioavailability and physical stability significantly as compared to the pure drug of NIMO.

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