Food Polyamine and Cardiovascular Disease -An Epidemiological Study-

Abstract

The purpose of this study was to examine the contribution of dietary polyamines toward preventing cardiovascular disease (CVD). Age-standardized mortality rates as well as other relevant information regarding individuals with CVD were gathered from the World Health Organization and the International Monetary Fund in 48 different European and other Western countries. Food supply data were collected from the database of the United Nations, and the amount of dietary polyamines was estimated by using polyamine concentrations in foods from published sources. The association between CVD mortality and the amount of polyamines was investigated by performing a series of multiple linear regression analyses. Analyses using factors known to modulate the risk of CVD including: Gross Domestic Product (GDP) (standardized regression coefficient (r) = -0.786, p < 0.001) and the amount of fruits, vegetable, nuts, and beans (r = -0.183, p = 0.001) but not including polyamines, showed negative associations with CVD, while smoking rate (r = 0.139, p = 0.041) and whole milk amount (r = 0.131, p = 0.028) showed positive associations with CVD. When the amount of polyamines was added to the analyses as a covariate, GDP (r = -0.864, p < 0.001) and polyamines (r = -0.355, p = 0.007) showed negative associations with CVD, while smoking rate (r = 0.183, p = 0.006) and whole milk (r = 0.113, p = 0.041) showed positive associations with CVD. The inverse association between dietary polyamines and CVD mortality revealed by the present study merits further evaluation.

Integrin-mediated type II TGF-β receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling

“…Although our findings suggest that activation of TCPTP might be beneficial in TGF-β-driven fibrotic diseases, spermidine is not a selective TCPTP activator. It has previously been shown that long-term polyamine intake can have both beneficial and deleterious effects: it can decrease mortality and incidence of colon cancer in aged mice (51) and protect against cardiovascular mortality in humans (52), but can also cause a decline in human renal function (53). Nevertheless, our findings support the need to generate more selective and safer TCPTP activators for the prevention and treatment of TGF-β-mediated kidney disease.…”

Antioxidant properties of human milk

“…Their antioxidant activities protect lipids and proteins, stabilize the negative charges of DNA and RNA transcription and protect DNA from oxidative damage from gamma, x and UV rays [21]. Spermine and spermidin have significant antiglycation activity at physiological concentrations, protect against chronic diseases [22] and have been related to obesity [23,24]. Polyamines are actively synthesized in the mammary gland during lactation.…”

Biological Effects of Polyamines on the Prevention of Aging-associated Diseases and on Lifespan Extension

“…The study was an ecological investigation, and the data used do not indicate the amount of foods actually consumed; however, as the food supply likely reflects the food demand, the analysis using relative amounts may reflect the food preferences of the people in each country. The study results indicated that the Mediterranean diet preferred in Mediterranean countries is associated with increased polyamine concentrations (Binh et al, 2011;Soda et al, 2012). Notably, although olive oil and wine, two components of the Mediterranean diet, contain no polyamines, people who prefer these ingredients also prefer foods rich in polyamines per calorie (Binh et al, 2011).…”