Food Protein‐Derived Bioactive Peptides: Production, Processing, and Potential Health Benefits

Udenigwe, Chibuike C.; Aluko, Rotimi E.

doi:10.1111/j.1750-3841.2011.02455.x

Cited by 770 publications

(550 citation statements)

References 135 publications

(180 reference statements)

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“…Recall that oxidative metabolism is essential for survival of cells, but it generates free radicals (and other reactive oxygen species) as side effect -which may cause oxidative damage. Antioxidant activity has been found specifically in whey proteins, probably via scavenging of such radicals via Tyr and Cys amino acid residueswhich is predominantly based on proton-coupled single electron or hydrogen atom transfer mechanisms; or else chelation of transition metals [167][168].…”

Section: Functional Ingredients From Whey Proteinsmentioning

confidence: 99%

Whey Proteins as Source of Bioactive Peptides Against Hypertension

Tavares¹,

Malcata²

2013

Bioactive Food Peptides in Health and Disease

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Section: Functional Ingredients From Whey Proteinsmentioning

confidence: 99%

Whey Proteins as Source of Bioactive Peptides Against Hypertension

Tavares¹,

Malcata²

2013

Bioactive Food Peptides in Health and Disease

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“…A number of phytochemicals, including resveratrol, quercetin and flavonoids, have been demonstrated to exhibit marked anti-cancer activity (7)(8)(9). Similarly, foodborne proteins and polypeptides have attracted attention due to their specific advantages as anti-cancer substances (10,11). Compared with certain small-molecule drugs, polypeptides exhibit characteristics of increased affinity, marked ability of specific targeting and decreased toxicity; furthermore, polypeptides exhibit increased permeability in tissues compared with protein-based drugs (12).…”

Section: Introductionmentioning

confidence: 99%

Lunasin: A promising polypeptide for the prevention and treatment of cancer

et al. 2017

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Abstract. Strategies for the treatment of cancer remain unsatisfactory due to the poor understanding of the complicated underlying molecular mechanisms of carcinogenesis. A number of types of cancer exhibit a marked association with dietary habits and lifestyles. Therefore, the modulation of dietary habits or lifestyles may be an effective strategy for preventing the formation and progression of cancer. Proteins and polypeptides from soybean have been developed as healthcare products due to their marked activity in inhibiting the progression of cancer at various stages. Lunasin, containing 43 amino acid residues, is one such example of a soybean-derived polypeptide that has been demonstrated to exhibit marked anti-cancer activity. In the present review, studies of the underlying molecular mechanisms and potential advantages of lunasin in the prevention and treatment of cancer have been examined, to provide a theoretical reference for the development of natural product-based agents or healthcare products for the prevention and treatment of cancer. IntroductionCancer is well-known to be one of the leading causes of mortality worldwide (1). However, the therapy of various types of cancer remains unsatisfactory due to the poor understanding of the complicated underlying molecular mechanisms of carcinogenesis. A number of epidemiological studies have demonstrated that a number of types of cancer exhibit a marked association with dietary habits and lifestyles (2-4). A statistical study has demonstrated that ~3.07 million individuals in China were diagnosed with cancer in 2012, which accounts for 1/5 of the total number of patients with cancer worldwide (5). Furthermore, ~2.21 million patients succumbed to cancer in China, which is ~25% of the total mortality worldwide due to cancer (5). Epidemiological evidence has demonstrated that cancer in 35% of patients exhibits a marked association with lifestyle, particularly diet (2). Therefore, the adjustment of dietary habits and lifestyles may be an effective strategy to prevent carcinogenesis. Cancer cell-and tumor-bearing animal models have demonstrated that the consumption of foods containing natural compounds with anti-cancer activity is able to markedly reduce the risk of cancer, and increase the sensitivity of cancer cells to treatment (6). A number of phytochemicals, including resveratrol, quercetin and flavonoids, have been demonstrated to exhibit marked anti-cancer activity (7-9). Similarly, foodborne proteins and polypeptides have attracted attention due to their specific advantages as anti-cancer substances (10,11). Compared with certain small-molecule drugs, polypeptides exhibit characteristics of increased affinity, marked ability of specific targeting and decreased toxicity; furthermore, polypeptides exhibit increased permeability in tissues compared with protein-based drugs (12). Therefore, polypeptides have been recognized as potential natural anti-cancer substances for inhibiting the development and progression of cancer at different stages (13).Following ...

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“…CLA. Another kind of bioactive components produced by microbes during fermentation process of foods are bioactive peptides [13,14]. Various probiotics and other microbes have been known for production of bioactive peptides from milk proteins, wheat protein and various other plant and meat proteins, that exert various health beneficial effects i.e.…”

mentioning

confidence: 99%